ID FTSY_METJA Reviewed; 409 AA.
AC Q57739;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 29-MAY-2013, entry version 82.
DE RecName: Full=Signal recognition particle receptor FtsY;
DE Short=SRP receptor;
GN Name=ftsY; OrderedLocusNames=MJ0291;
OS Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 /
OS JCM 10045 / NBRC 100440) (Methanococcus jannaschii).
OC Archaea; Euryarchaeota; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanocaldococcus.
OX NCBI_TaxID=243232;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D.,
RA Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D.,
RA Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I.,
RA Overbeek R., Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A.,
RA Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D.,
RA Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C.,
RA Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M.,
RA Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
CC -!- FUNCTION: Involved in targeting and insertion of nascent membrane
CC proteins into the cytoplasmic membrane. Acts as a receptor for the
CC complex formed by the signal recognition particle (SRP) and the
CC ribosome-nascent chain (RNC) (By similarity).
CC -!- SUBUNIT: Part of the signal recognition particle protein
CC translocation system, which is composed of SRP and FtsY (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein;
CC Cytoplasmic side. Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the GTP-binding SRP family. FtsY subfamily.
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DR EMBL; L77117; AAB98276.1; -; Genomic_DNA.
DR PIR; D64336; D64336.
DR RefSeq; NP_247264.1; NC_000909.1.
DR ProteinModelPortal; Q57739; -.
DR STRING; 243232.MJ0291; -.
DR EnsemblBacteria; AAB98276; AAB98276; MJ_0291.
DR GeneID; 1451146; -.
DR KEGG; mja:MJ_0291; -.
DR eggNOG; COG0552; -.
DR KO; K03110; -.
DR OMA; ISIAYIT; -.
DR ProtClustDB; PRK14974; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031226; C:intrinsic to plasma membrane; IEA:HAMAP.
DR GO; GO:0005525; F:GTP binding; IEA:HAMAP.
DR GO; GO:0003924; F:GTPase activity; IEA:HAMAP.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR HAMAP; MF_00920; FtsY; 1; -.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR InterPro; IPR004390; SR_rcpt_FtsY.
DR InterPro; IPR000897; SRP54_GTPase_dom.
DR Pfam; PF00448; SRP54; 1.
DR Pfam; PF02881; SRP54_N; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00962; SRP54; 1.
DR SMART; SM00963; SRP54_N; 1.
DR SUPFAM; SSF47364; SRP54; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00064; ftsY; 1.
DR PROSITE; PS00300; SRP54; 1.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Cytoplasm; GTP-binding; Membrane;
KW Nucleotide-binding; Receptor; Reference proteome.
FT CHAIN 1 409 Signal recognition particle receptor
FT FtsY.
FT /FTId=PRO_0000101218.
FT NP_BIND 209 216 GTP (By similarity).
FT NP_BIND 291 295 GTP (By similarity).
FT NP_BIND 349 352 GTP (By similarity).
SQ SEQUENCE 409 AA; 45755 MW; 4FBCFF8290693EEC CRC64;
MFGKLKEKLL ETASKITEKI YSKGEAEEVK EEKEEKSKIS FTSLFKKEPK KEEVKKEKAE
EEIKKSEIVK TEPSEKVEEA KEEIKEIKEE KEEKKITFFD RFGLTRAIKK VLKKEVVILE
EDIEDVLEEL EIALLEADVA LEVVEKLIEN IKNELVGRKI SPDDNVEEIT INAVKNAIKN
ILSQEKIDIE EIIKKNKAEG KPTVIVFVGI NGTGKTTTIA KLAYKLKQKG YSVVLAAGDT
FRAGAIEQLE QHAKNVGVKV IKHKPGADSA AVIYDAIQHA KARGIDVVLA DTAGRQATNV
NLMEEIKKVV RVTKPDLVIF VGDALTGNDA VYQAEEFNRA VNIDGIILTK VDADAKGGAA
LSIGYAIGKP ILYLGVGQRY QDLIEFDADW MVRKLFGEEE FEFSTEREF
//
