ID Q57U52_TRYB2 Unreviewed; 1267 AA.
AC Q57U52; D6XMH2;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE AltName: Full=ATP pyrophosphate-lyase {ECO:0000256|ARBA:ARBA00032597};
DE AltName: Full=Adenylyl cyclase {ECO:0000256|ARBA:ARBA00032637};
GN Name=Tb08.6H23.200 {ECO:0000313|EMBL:AAZ13552.1};
GN ORFNames=Tb927.8.7930 {ECO:0000313|EMBL:AAX70866.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:AAX70866.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:AAZ13552.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ13552.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [2] {ECO:0000313|EMBL:AAZ13552.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ13552.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
RN [3] {ECO:0000313|EMBL:AAX70866.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX70866.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT ".";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AAZ13552.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ13552.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2
RT through 8.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Could act as a receptor for an unknown ligand.
CC {ECO:0000256|ARBA:ARBA00002708}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC159456; AAX70866.1; -; Genomic_DNA.
DR EMBL; CP000071; AAZ13552.1; -; Genomic_DNA.
DR RefSeq; XP_847618.1; XM_842525.1.
DR AlphaFoldDB; Q57U52; -.
DR STRING; 185431.Q57U52; -.
DR PaxDb; 5691-AAZ13552; -.
DR GeneID; 3659800; -.
DR KEGG; tbr:Tb927.8.7930; -.
DR VEuPathDB; TriTrypDB:Tb927.8.7930; -.
DR eggNOG; KOG0618; Eukaryota.
DR InParanoid; Q57U52; -.
DR OMA; NTTHIEQ; -.
DR OrthoDB; 1698689at2759; -.
DR Proteomes; UP000008524; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004016; F:adenylate cyclase activity; ISM:GeneDB.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; ISM:GeneDB.
DR CDD; cd07556; Nucleotidyl_cyc_III; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW Lyase {ECO:0000313|EMBL:AAX70866.1};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AAX70866.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524}.
FT DOMAIN 886..1040
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1267 AA; 140942 MW; 5D73DCC8A19CAC1D CRC64;
MASFMRLVTP LGAAVACSHL LMVVLPLLLL IPGLCADKDC NSSSVTVRVY NLLYSFKISS
KIYEPVIAGF NASLHAHNDD LPANVCIEVE HVHARSDEDY VSYLKNKIDG DAAVQNKSEL
PIVLGPFGDV TTLHLTRELE KFEIVAFSPF TGSSDVRVWK KNLYYLTASP VAQVLALIRY
AVSQLRFQRL GFMYLKGVFY GDKEYKLTLK VMSIMGRKLC GVFELDSSTD GRASDDDFEA
AWKRFAPTMP QGVIVFGSPI EDTKRFLMKF LGSNELRGAY ILIPSMLQYV IKNSWVKELA
VKNFVPERVI LTGPSPLAND NEYIAVRKFQ TDMEKYLETN GKLNGHNYEK GHFYQHSTDG
ELMVHGWITG EVLWRTLGSR ELLCNRTAYM NSLYNQRRYV IDDLVIGDFG GECEGKAGQR
GAACKCNQGG NVVYMKRMGT DRNLHPVKEG VVTLASSRCY TNLLQLYAPL NGIMFRLEDN
PLAQRITEEY RDGASPVVGK GQLGQGDRFF LHELNSTSSA TKHNMLEEVK ERVVTAVFGV
VDDALLSMTD MTFIDPIPLS PRLKHPGRNV LHLSPTIEQQ IFVMVERVVV PNSWGSVHAI
VRSSDARGIK SVLRKTFWAL GGSLGAFDEV TDGESVKSLL PHSGFVLVIG LTEADITAIA
EHLDNHREVR VFVLFFDVAL LYSEFVKVFK KHPQAAERLL FATSLPHWAD NNTTSETVQE
FHRDVGNESK WTPLALLGYA TARAMESVVL QMGRVNSEEL INTIFSQSVI VADDMWYGPF
EDSCSNSRWS SAKDCIVNYG ATHISVWSMA RVLNPSVPPV SGVATPSIRY YKDGLNMTEE
EFIGTIVGTI LCLIALVLIV MLMRKCMRGD TRDNENAPKE LTDPVTLIFT DIESSTAQWA
AHPELMPDAV ATHHRLIRTL ISKYGCYEVK TVGDSFMIAC KSPFAAAQLA CDLQRCFLEH
DWKTDVFDTS YREFERQRAE DDGDYVPPTG HLDPDVYSRL WNGLRVRVGI HTGLCDIRHD
EVTKGYDFYG RTSNMAARTE SIANGGQVLL TRSTYLSLST SEREQLNVTA LGDVPLRGVP
KPVEMYQLNA VPGRTFTTLR LDHEVADDED TSVSCSDGSS IGAVLSDAAH QVVAFIEALL
GAFPTAQRKK LLMPFCTRWG VSLPYNVSDT WDATTCRNVT RLLAARVGRV VDFGTKNTHD
SVQSFDRRSG TFPPGLVASV PEECSLASTS SCIQSSCSVV YMMNGSDDDD TSKYSPKHCN
MCPLLPE
//
