ID Q581Z6_TRYB2 Unreviewed; 1030 AA.
AC Q581Z6; D6XKS3;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 08-NOV-2023, entry version 116.
DE SubName: Full=Pitrilysin-like metalloprotease {ECO:0000313|EMBL:AAX79407.1};
GN Name=Tb08.26N11.280 {ECO:0000313|EMBL:AAZ12953.1};
GN ORFNames=Tb927.8.1860 {ECO:0000313|EMBL:AAX79407.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:AAX79407.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:AAX79407.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79407.1};
RA El-Sayed N.M., Khalak H., Adams M.D.;
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAZ12953.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ12953.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [3] {ECO:0000313|EMBL:AAZ12953.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ12953.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
RN [4] {ECO:0000313|EMBL:AAX79407.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79407.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT ".";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AAZ12953.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ12953.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2
RT through 8.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|RuleBase:RU004447}.
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DR EMBL; AC091701; AAX79407.1; -; Genomic_DNA.
DR EMBL; CP000071; AAZ12953.1; -; Genomic_DNA.
DR RefSeq; XP_847019.1; XM_841926.1.
DR AlphaFoldDB; Q581Z6; -.
DR STRING; 185431.Q581Z6; -.
DR PaxDb; 5691-AAZ12953; -.
DR GeneID; 3659170; -.
DR KEGG; tbr:Tb927.8.1860; -.
DR VEuPathDB; TriTrypDB:Tb927.8.1860; -.
DR eggNOG; KOG2019; Eukaryota.
DR InParanoid; Q581Z6; -.
DR OMA; FPFQVHY; -.
DR OrthoDB; 5477696at2759; -.
DR Proteomes; UP000008524; Chromosome 8.
DR GO; GO:0005739; C:mitochondrion; ISM:GeneDB.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; ISM:GeneDB.
DR GO; GO:0016485; P:protein processing; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; ISM:GeneDB.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR013578; Peptidase_M16C_assoc.
DR PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR Pfam; PF08367; M16C_assoc; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SMART; SM01264; M16C_associated; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:AAX79407.1};
KW Metalloprotease {ECO:0000313|EMBL:AAX79407.1};
KW Protease {ECO:0000313|EMBL:AAX79407.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524}.
FT DOMAIN 489..764
FT /note="Peptidase M16C associated"
FT /evidence="ECO:0000259|SMART:SM01264"
SQ SEQUENCE 1030 AA; 114529 MW; 2351219EC7582F5A CRC64;
MIRRCAVPLC AASAMPRGGH PLLKLKNAHG FTHKSTRRFD ELNITAYEWQ HDSTGALYYH
LDTNDRNCTF CIGFRTPAKD NKGISHVLEH TTLCGSKKYP VRDPFFMMLK RSLNNFMNAM
TGADYTLYPF ATTNARDFCN LLDVYLDAVF HPLLRLEDFK QEGHRVEVEE DDSAKRRLVY
NGVVFNEMRG VVSEPSQHYA HSLMKTMLPN THYEHISGGY PPEVLKLTYE ELVAFHKRHY
HPTNSITITY GEQNPGSWMA TLNEYFSSFE RGEVVAVFGL AEKNRFAEPK RVTMEGPLNP
MGNPQCQKRV SVSFGVQKED KNMKDIVELS VLDILLSSGP SSPIYQALIE SQIGSRYAPM
NGYSSYLASP LVSYGVEGVD EARANSDEEV LSAVITALER VSKEGFEQRR VQSVIFQEEL
QQRHRAADYG VNLCTGLCAM GLCRAENNPL DFIDWLPHLR QLEAEQAKSL LPRISRNLLN
NPHRALVSVS AKKDFLDSLR DTITHMEEKL NDGATDAQKD EIKKETEKWL ERVRAPQNGD
ILPTLKVGDI PCQSFQEPLP QPKADGQNTS LLRAPPPLKP PVGVYTIGYP TNGLVYVHGL
APFSAATVLL LEKAENDALA GIPLSHSLLG SLGAGKYTFK ELSIATDLVC GGFSFSPQLN
QSYCNKSEYI TGTAYGFYTT KEKLHDALEL LKMTLLEPHT SVEDDGVRGR TLSVAKARCS
GVIQRLQHEG NRVATSLAVS HLTRCGAVRE SWHGLAQSSY ASEMLEKLQS SNEGISHSAV
ATILEHHSCF VQSFAANLCR GVLWATCEEQ HRCEVENMLA SFLSGFPKGE DTSSCACLPS
LGRIAREDVV ELCRSLPIDT SYAAIAIAND LDWTHKQQAP LRVACQLLAN EYLHRRVREE
GGAYGSGVKA TLGAEVGGVT MSSYRDPTPE ATVRVFKEAG DWLSEASNVT QLRVDESKLR
LFAGIDAPYA ADSFGESYFL HGIRPEQKQE MRDALLSVEP KDVVEVARYF DVGKNHGAVV
GILRPEERKE
//
