ID Q586Q4_TRYB2 Unreviewed; 1254 AA.
AC Q586Q4; D7SFY0;
DT 02-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 02-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=Dpy-30 motif containing protein {ECO:0008006|Google:ProtNLM};
GN Name=30M24.320 {ECO:0000313|EMBL:AAQ15910.1};
GN ORFNames=Tb927.2.4520 {ECO:0000313|EMBL:AAX80182.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:AAX80182.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:AAX80182.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX80182.1};
RA El-Sayed N.M., Khalak H., Adams M.D.;
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAQ15910.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAQ15910.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [3] {ECO:0000313|EMBL:AAQ15910.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAQ15910.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
RN [4] {ECO:0000313|EMBL:AAX80182.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX80182.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT ".";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AAQ15910.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAQ15910.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2
RT through 8.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AE017150; AAQ15910.1; -; Genomic_DNA.
DR EMBL; AC007865; AAX80182.1; -; Genomic_DNA.
DR RefSeq; XP_951642.1; XM_946549.1.
DR AlphaFoldDB; Q586Q4; -.
DR STRING; 185431.Q586Q4; -.
DR PaxDb; 5691-AAQ15910; -.
DR GeneID; 3655753; -.
DR KEGG; tbr:Tb927.2.4520; -.
DR VEuPathDB; TriTrypDB:Tb927.2.4520; -.
DR eggNOG; KOG3078; Eukaryota.
DR InParanoid; Q586Q4; -.
DR OMA; CALAFMC; -.
DR OrthoDB; 156889at2759; -.
DR Proteomes; UP000008524; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004017; F:adenylate kinase activity; IBA:GO_Central.
DR GO; GO:0004127; F:cytidylate kinase activity; IBA:GO_Central.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IBA:GO_Central.
DR CDD; cd22967; DD_AK7; 1.
DR Gene3D; 1.20.890.10; cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR047499; DD_AK7.
DR InterPro; IPR007858; Dpy-30_motif.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR15361; RAD51/NUKS-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR15361:SF5; RAD51_INTERACT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF05186; Dpy-30; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524}.
FT REGION 202..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 376..476
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 202..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..241
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..740
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..784
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1254 AA; 143936 MW; 1A0AFE0AE1FE7139 CRC64;
MKRVLVLNVD SFVGRHVCRQ FYDAKEYLVD GTFYHHQSTT EAPTPPKMEE LGATRSQSSG
LCGTTEVQFQ ETNSTGINEV VPTVRLLNGC PPDATVASGA DSAAGKESVH HYVNDMRPYL
NAVVPRHGEI NDEEFRSQLL TYDIIIAVLE ENAFEAECAI KILKGTHYNV EKTFVLVSNV
FTWAQTDMRE LENRRAERRA AREAARLQRE QERANREQST EDGDETEEEE EEEEEEEQLE
VKVWSDEEYR RRYPDTRYHG WRALEHAVKQ ANSETLHTYV LWAGLPYGAG EDLLRDHFLS
AWRHQPITQY GDGSNYVPTV HVKDLSRIIF LVGSSYDTLE DRYMFVVDQG NNTQKEILDG
IRAYIGGEIE VTEPVIDRDK QVLDEIEERK TSEELKRREE SINESIKNYM EELDTLAREK
AISLKRKREL EEAAKQRSMY KSIMNAKRCT DGEEKINREK EELNSHECAV EGIELKMIYL
KMELSQKEFE RDLVTEYNRL RSLDQQVREK DKIGLLVKGN VEEYDNKVAA PEIAMADIRL
YIDEPHGLGN WFSALNVRCE SGAALQLLGE SDWVSLGGFV ANVDKVVQEF KSERLLCPMR
LVIAGPPFGR VPEISRILAN LFDVVHLTIE DIIIAFEAHV AKVREQMVTI LLRRRARRQA
AREERIRRER QRRLLERKER LRAKREAARG GNGEDDDDDE EGEEEEEEEE NEEEEEEDFE
EEESEEGAAT QLDDEEGEEG QGIPGGGLVS PSPKLDGDEN IIPEHQLLNG QDEEEEDEEE
SETDSNADTK ARQLAQQVDE QERFEIATLR EEYRFCTKLL NLRLLNGEFP QIPKSDEEEE
EEEEEEEVEV NRRGRRKSKS KTAVNTSPDP PPTIRYFDEA LAVMVRWRLR QADCKNQGYI
LENFPRTVRQ ARLVFLAYTP EQKEQQRPKL YRNSAERAQP PKPCDFAFPL PSLEELDDGR
RREMLNAMDG KSFLQSDDAL APTNDALFPD CFIFIQASRD IAEAEVSELK QDIAEGGDHK
DPHEELTHFL TNYRLDAPPT ESLLSWYQTV VVEKPEEGED APAGGGWDGE EPIGGERPPR
SASIVFAPMF TPESAVQTDC EEGGGQVVIE DGFVEYCNVL RERVLNNIGL STCGEVIESI
MEETKSERSL HRSLERESGA LSHLKRGFKT FLRIDSSREK ALVEEERCVL RYFEAKEMFT
EIAGLEDLPS ELYLMRYVLP SLTPLMAEVV RLRPEDPVAA LADKLFDYKR RTEI
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