ID Q58J23_ANCCA Unreviewed; 354 AA.
AC Q58J23;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Transforming growth factor beta {ECO:0000313|EMBL:AAX36081.1};
GN Name=tgh-1 {ECO:0000313|EMBL:AAX36081.1};
OS Ancylostoma caninum (Dog hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=29170 {ECO:0000313|EMBL:AAX36081.1};
RN [1] {ECO:0000313|EMBL:AAX36081.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16140304; DOI=10.1016/j.ijpara.2005.07.005;
RA Freitas T.C., Arasu P.;
RT "Cloning and characterisation of genes encoding two transforming growth
RT factor-beta-like ligands from the hookworm, Ancylostoma caninum.";
RL Int. J. Parasitol. 35:1477-1487(2005).
RN [2] {ECO:0000313|EMBL:AAX36081.1}
RP NUCLEOTIDE SEQUENCE.
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AY942843; AAX36081.1; -; mRNA.
DR AlphaFoldDB; Q58J23; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF263; PROTEIN DECAPENTAPLEGIC; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..354
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004252103"
FT DOMAIN 225..354
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 221..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..245
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 354 AA; 40104 MW; 331ABF53A284D65B CRC64;
MNRALLVVCV SVVLTLSTPP VSASLALSPH ELGMLQKGFL RRFGFPRVPN LSGPALPIPD
HVWDIYEEAS EDGEMDWIRH YYPKELFELN SGLLVSYNLS ASVRNAAEEE VVRANLKIKL
HQTKRPTRVS VYEVEQQHPE IRRLLDSKTI DVSDTSRPTQ WVDLDVAPAL RASRNDHDTV
TLFIDHPDTT IYSSEPHSMS TLPLTRHQSL PLVVYSVMKE PSRVRRKRAA PTRRDRKKQR
KQHHRHNATE SGICRKKALY VDFEEIGWQE WILAPKSYEA GQCVGSCPHP LPAHLNATNH
AIGQSLTNSL NPQVPPPCCV PTETTHLSIL FLDVDNKIII KNYPDMRVEA CGCR
//