ID Q58X74_9HIV1 Unreviewed; 346 AA.
AC Q58X74;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AAX54752.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAX54752.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAX54752.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B22-00105194 {ECO:0000313|EMBL:AAX54752.1};
RX PubMed=17919099; DOI=10.1089/aid.2006.0256;
RA Holguin A., De Arellano E.R., Soriano V.;
RT "Amino acid conservation in the gp41 transmembrane protein and natural
RT polymorphisms associated with enfuvirtide resistance across HIV-1
RT variants.";
RL AIDS Res. Hum. Retroviruses 23:1067-1074(2007).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; AY751049; AAX54752.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Viral envelope protein {ECO:0000313|EMBL:AAX54752.1};
KW Virion {ECO:0000313|EMBL:AAX54752.1}.
FT DOMAIN 19..209
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 209..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAX54752.1"
FT NON_TER 346
FT /evidence="ECO:0000313|EMBL:AAX54752.1"
SQ SEQUENCE 346 AA; 39458 MW; 152D00817A612E07 CRC64;
AVGIGAVFLG FLGAAGSTMG AASLTLTVQA RQLLSGIVQQ QSNLLKAIEA QHHLLQLTVW
GIKQLQARVL AVERYLRDQQ LLGIWGCSGK LICTTTVPWN TSWSNKSYED IWGSNMTWMQ
WEKEIDNYTH IIYSLIENSQ NQQEKNELDL LELDNWASLW NWFDITNWLW YIKIFIMIIG
GLVGLRIVFT VLSIINRVRQ GYSPLSFQTR LPAPRGPDRP EGIGEEGGER NRDGSSQLVG
GFLALFWDDL RSLCLFSYHR LRDLLFIVTR IVELLGRRGW EALKYCWNLL QYWSQELKNS
AVSLLNATAI AVAEGTDRVL EVLQRAGRAF LHIPRRIRQG LERALL
//
