GenomeNet

Database: UniProt
Entry: Q58Z27_LACRH
LinkDB: Q58Z27_LACRH
Original site: Q58Z27_LACRH 
ID   Q58Z27_LACRH            Unreviewed;       250 AA.
AC   Q58Z27;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=Tyrosine-protein kinase CpsD {ECO:0000256|ARBA:ARBA00019200};
DE            EC=2.7.10.2 {ECO:0000256|ARBA:ARBA00011903};
GN   Name=wze {ECO:0000313|EMBL:AAW22470.1};
OS   Lacticaseibacillus rhamnosus (Lactobacillus rhamnosus).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=47715 {ECO:0000313|EMBL:AAW22470.1};
RN   [1] {ECO:0000313|EMBL:AAW22470.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=R {ECO:0000313|EMBL:AAW22470.1};
RA   Provencher C., Sirois S., Lapointe G., Roy D.;
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAW22470.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=R {ECO:0000313|EMBL:AAW22470.1};
RX   PubMed=15941992; DOI=10.1099/mic.0.27852-0;
RA   Peant B., Lapointe G., Gilbert C., Atlan D., Ward P., Roy D.;
RT   "Comparative analysis of the exopolysaccharide biosynthesis gene clusters
RT   from four strains of Lactobacillus rhamnosus.";
RL   Microbiology 151:1839-1851(2005).
CC   -!- FUNCTION: Involved in the regulation of capsular polysaccharide
CC       biosynthesis. Autophosphorylation of CpsD attenuates its activity and
CC       reduces the level of encapsulation. May be part of a complex that
CC       directs the coordinated polymerization and export to the cell surface
CC       of the capsular polysaccharide. {ECO:0000256|ARBA:ARBA00024964}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001149};
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005132}.
CC   -!- SIMILARITY: Belongs to the CpsD/CapB family.
CC       {ECO:0000256|ARBA:ARBA00007316}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY659978; AAW22470.1; -; Genomic_DNA.
DR   RefSeq; WP_070786841.1; NZ_RINB01000030.1.
DR   AlphaFoldDB; Q58Z27; -.
DR   UniPathway; UPA00934; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05387; BY-kinase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR025669; AAA_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005702; Wzc-like_C.
DR   NCBIfam; TIGR01007; eps_fam; 1.
DR   PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR   PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR   Pfam; PF13614; AAA_31; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Capsule biogenesis/degradation {ECO:0000256|ARBA:ARBA00022903};
KW   Exopolysaccharide synthesis {ECO:0000256|ARBA:ARBA00023169};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT   DOMAIN          69..210
FT                   /note="AAA"
FT                   /evidence="ECO:0000259|Pfam:PF13614"
SQ   SEQUENCE   250 AA;  27414 MW;  340A531D3E424B86 CRC64;
     MNFSLEKVLH RHKEDQETQK NGVMLVTFAE PKHVVSEQFR TVRTNIEFAG AALDQCQVIM
     FTSSAMFEGK PTVSANVAVT WAQAGKKVLL IDADLRRPTV HATFRTLNLD GVTTVLTGKE
     KPDDVVEETF VDNMSIITSG PVPPNPSELL NSKRMAGLLE WAREKYDIIV LDAPPVLAVS
     DVQVLVPKTD GVVVVANMGK TLKGDLKRTV EVLKLANAKI LGSVERVKAK HGDRGYGYGY
     GYGYGNESNK
//
DBGET integrated database retrieval system