ID   HRDD_STRGR              Reviewed;         332 AA.
AC   Q59914;
DT   24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   01-MAY-2013, entry version 71.
DE   RecName: Full=RNA polymerase principal sigma factor HrdD;
GN   Name=hrdD;
OS   Streptomyces griseus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IMRU 3570;
RX   PubMed=7883183; DOI=10.1016/0378-1119(94)00759-L;
RA   Marcos A.T., Diez B., Gutierrez S., Fernandez F.J., Oguiza J.A.,
RA   Martin J.F.;
RT   "Three genes hrdB, hrdD and hrdT of Streptomyces griseus IMRU 3570,
RT   encoding sigma factor-like proteins, are differentially expressed
RT   under specific nutritional conditions.";
RL   Gene 153:41-48(1995).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are
CC       then released.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family.
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DR   EMBL; X79980; CAA56305.1; -; Genomic_DNA.
DR   PIR; S49185; S49185.
DR   ProteinModelPortal; Q59914; -.
DR   SMR; Q59914; 91-167.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-dependent transcription, initiation; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000943; RNA_pol_sigma70.
DR   InterPro; IPR009042; RNA_pol_sigma70_r1_2.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR007624; RNA_pol_sigma70_r3.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3_r4.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00140; Sigma70_r1_2; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF04539; Sigma70_r3; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   PRINTS; PR00046; SIGMA70FCT.
DR   SUPFAM; SSF88946; Sigma_r2; 1.
DR   SUPFAM; SSF88659; Sigma_r3_r4; 2.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
DR   PROSITE; PS00715; SIGMA70_1; 1.
DR   PROSITE; PS00716; SIGMA70_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Sigma factor; Transcription; Transcription regulation.
FT   CHAIN         1    332       RNA polymerase principal sigma factor
FT                                HrdD.
FT                                /FTId=PRO_0000093995.
FT   DNA_BIND    294    313       H-T-H motif (By similarity).
FT   MOTIF       124    137       Polymerase core binding (Potential).
SQ   SEQUENCE   332 AA;  36769 MW;  A5807F38CEDB0838 CRC64;
     MATRAVARRQ PAASGETGAA GSVRATGEIA DRDLVGMYLD EIARTPLLDA AKEVELSQTI
     EAGVYAGKIL DGEVDSDSAG ASREELEALV AEGERAKDVF IRSNLRLVVA VARRYPRSGL
     PLLDLIQEGN AGLVRAVEKF DYAKGFKFST YATWWIRQAI TRSIADQSRT IRLPVHLVEE
     LGRIRRVQRE FNRENGRDPE PAEIAAELSS TPERVTDVLD WARDPVSLNM SVDDEGETQF
     GDLLEDTSAV SPEQSVLTLL RSEELDDLIG QLDDRTASII KMRYGIEDGR ERTLTEVGKQ
     HGLTRERIRQ IEKHALLELK RMAHDTGFDA AA
//