ID Q59PW1_CANAL Unreviewed; 175 AA.
AC Q59PW1;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 13-SEP-2023, entry version 125.
DE SubName: Full=Monothiol glutaredoxin {ECO:0000313|EMBL:AOW26410.1};
GN OrderedLocusNames=CAALFM_C107630WA {ECO:0000313|EMBL:AOW26410.1},
GN orf19.10298 {ECO:0000313|CGD:CAL0000183749};
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561 {ECO:0000313|EMBL:AOW26410.1, ECO:0000313|Proteomes:UP000000559};
RN [1] {ECO:0000313|EMBL:AOW26410.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2] {ECO:0000313|EMBL:AOW26410.1, ECO:0000313|Proteomes:UP000000559}
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=17419877; DOI=.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3] {ECO:0000313|EMBL:AOW26410.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=24025428; DOI=.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
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DR EMBL; CP017623; AOW26410.1; -; Genomic_DNA.
DR RefSeq; XP_711724.1; XM_706632.1.
DR AlphaFoldDB; Q59PW1; -.
DR SMR; Q59PW1; -.
DR STRING; 237561.Q59PW1; -.
DR EnsemblFungi; C1_07630W_A-T; C1_07630W_A-T-p1; C1_07630W_A.
DR GeneID; 3646660; -.
DR KEGG; cal:CAALFM_C107630WA; -.
DR CGD; CAL0000183749; orf19.10298.
DR VEuPathDB; FungiDB:C1_07630W_A; -.
DR eggNOG; KOG0911; Eukaryota.
DR HOGENOM; CLU_026126_2_0_1; -.
DR InParanoid; Q59PW1; -.
DR OMA; TKLMPQC; -.
DR OrthoDB; 1038at2759; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:1990229; C:iron-sulfur cluster assembly complex; IEA:EnsemblFungi.
DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:EnsemblFungi.
DR GO; GO:0015036; F:disulfide oxidoreductase activity; IEA:EnsemblFungi.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:EnsemblFungi.
DR GO; GO:0106034; P:protein maturation by [2Fe-2S] cluster transfer; IEA:EnsemblFungi.
DR GO; GO:0106035; P:protein maturation by [4Fe-4S] cluster transfer; IEA:EnsemblFungi.
DR GO; GO:0006970; P:response to osmotic stress; IEA:EnsemblFungi.
DR CDD; cd03028; GRX_PICOT_like; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR002109; Glutaredoxin.
DR InterPro; IPR033658; GRX_PICOT-like.
DR InterPro; IPR004480; Monothiol_GRX-rel.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR NCBIfam; TIGR00365; Grx4 family monothiol glutaredoxin; 1.
DR PANTHER; PTHR10293; GLUTAREDOXIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10293:SF16; GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL; 1.
DR Pfam; PF00462; Glutaredoxin; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000559}.
FT DOMAIN 56..123
FT /note="Glutaredoxin"
FT /evidence="ECO:0000259|Pfam:PF00462"
FT REGION 149..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 175 AA; 19444 MW; D79C5445CC4C0D62 CRC64;
MFRRSLLSTS RFINKSSSSL SPGLLLNNFR GNFQQSRFIS TELKDALDKA VTTSPVVLFM
KGTPEFPQCG FSRATIQILG QQGVDPEKFA AYNVLEDSEL REGIKEYSSW PTIPQLYVNG
EFIGGCDIIT SMAQNGELAE LLEESNALIP EENEPTTSEE NQETVQSANI KPNRN
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