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Database: UniProt
Entry: Q59R99_CANAL
LinkDB: Q59R99_CANAL
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ID   Q59R99_CANAL            Unreviewed;       821 AA.
AC   Q59R99;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   07-JUN-2017, entry version 68.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=VPH1 {ECO:0000313|CGD:CAL0000191982,
GN   ECO:0000313|EMBL:AOW29263.1};
GN   OrderedLocusNames=orf19.6863 {ECO:0000313|CGD:CAL0000191982};
GN   ORFNames=CAALFM_C405240CA {ECO:0000313|EMBL:AOW29263.1};
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
OC   Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561 {ECO:0000313|EMBL:AOW29263.1, ECO:0000313|Proteomes:UP000000559};
RN   [1] {ECO:0000313|EMBL:AOW29263.1, ECO:0000313|Proteomes:UP000000559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
RA   Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
RA   Davis R.W., Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2] {ECO:0000313|EMBL:AOW29263.1, ECO:0000313|Proteomes:UP000000559}
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs
RT   aligned on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3] {ECO:0000313|EMBL:AOW29263.1, ECO:0000313|Proteomes:UP000000559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates
RT   allele-specific measurements and provides a simple model for repeat
RT   and indel structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CP017626; AOW29263.1; -; Genomic_DNA.
DR   RefSeq; XP_712251.1; XM_707158.1.
DR   EnsemblFungi; KHC76611; KHC76611; W5Q_03825.
DR   EnsemblFungi; KHC86543; KHC86543; I503_03819.
DR   GeneID; 3646157; -.
DR   KEGG; cal:CAALFM_C405240CA; -.
DR   CGD; CAL0000191982; VPH1.
DR   KO; K02154; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000000559; Chromosome 4.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IDA:CGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:CGD.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IMP:CGD.
DR   GO; GO:0007035; P:vacuolar acidification; IMP:CGD.
DR   GO; GO:0007033; P:vacuole organization; IMP:CGD.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000559};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000559};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    411    435       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    456    473       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    533    555       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    567    588       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    627    645       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    727    750       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    756    779       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   821 AA;  93332 MW;  0132323ABCE8991E CRC64;
     MPEKEEAVFR SADMSLVQLY VPTEVARDII YKVGQLDIIQ FRDLNSKINE FQRSFVKELR
     KLDNVERQFN LFKRELDVRD IPIKLFPYDL DNVPPQTEID ELIEGSDLLE ERVIQLRDSV
     ETLYEKEKYL KQFKYTIQAV NNFFAVQGET TNDNEETALL SQLESGGATS GGGGDARSGS
     SFISGVINRD KVGVLQQILW RVLRGNLYYH NEDLPEEIYD FKNNTYVAKS SFIIFSHGSL
     IRERIRKICE SLDAELYNVD STSALRREQL DDVNTKTTDL STVLGESENA LNSELIAISR
     DLAKWWEIIA REKAVYKAMN NCDYDNSRKT LIAEGWTPTD SITELTTAIQ EYDASQSVPT
     IINVLDTNKT PPTYTRTNKF TYAFQAICDA YGVPKYKEIN PGLPTIVTFP FMFAIMFGDL
     GHGFIVTLAA AALVLNEKKL NAMKKDEIFD MAYTGRYVLL LMGVFSMYTG FIYNDVFSRS
     MSIFKSGWEW PEKFNVGETI YAKYVGTYSI GLDPAWHGTE NALLFSNSYK MKLSILMGYI
     HMSYSYVFSL VNYTYFNSMI DVIGNFIPGL LFMQGIFGYL SLCIVYKWSV DWFATGRQPP
     GLLNMLINMF LQPGDVPEPL YSGQSTIQVF LLLIALICVP WLLLVKPLYM KRQLEKEANQ
     HHGSYSQLAN DEESGVAGQE QEQENAAEDD DEDHEEHNFG DIMIHQVIHT IEFCLNCVSH
     TASYLRLWAL SLAHAQLSTV LWSMTIGNAF GPTGLIGTFM VVFLFAMWFV LSVCILVVME
     GTSAMLHSLR LHWVESMSKY FEGGGSAFEP FTFKGLLDSV L
//
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