ID Q5B857_EMENI Unreviewed; 1730 AA.
AC Q5B857; C8VI30;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 24-JAN-2024, entry version 136.
DE SubName: Full=PKS-like enzyme, putative (JCVI) {ECO:0000313|EMBL:CBF83055.1};
GN ORFNames=ANIA_03273 {ECO:0000313|EMBL:CBF83055.1};
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321 {ECO:0000313|EMBL:CBF83055.1, ECO:0000313|Proteomes:UP000000560};
RN [1] {ECO:0000313|Proteomes:UP000000560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC {ECO:0000313|Proteomes:UP000000560};
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.J., Wortman J.R., Batzoglou S.,
RA Lee S.I., Basturkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M., Hynes M., Paoletti M., Fischer R., Miller B.,
RA Dyer P., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2] {ECO:0000313|Proteomes:UP000000560}
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC {ECO:0000313|Proteomes:UP000000560};
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
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DR EMBL; BN001306; CBF83055.1; -; Genomic_DNA.
DR RefSeq; XP_660877.1; XM_655785.1.
DR STRING; 227321.Q5B857; -.
DR EnsemblFungi; CBF83055; CBF83055; ANIA_03273.
DR GeneID; 2874502; -.
DR KEGG; ani:AN3273.2; -.
DR VEuPathDB; FungiDB:AN3273; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_0_1; -.
DR InParanoid; Q5B857; -.
DR OMA; STIHCER; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000000560; Chromosome VI.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR45681:SF6; CARRIER DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45681; POLYKETIDE SYNTHASE 44-RELATED; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000560};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1648..1725
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1730 AA; 191728 MW; FB932F21E8F19122 CRC64;
MQPFADEYSA ALQQILRDGK LDDNIIYTSP VSGIRTFEDE VSCAEHWVQN MLQPVLFLDS
LTNLCLSSDL DQQVDAILEV GPHSALAGPI RQTMGLPAFE GKRISYLSCL SRGKNAVETM
QSLAATLHRQ GTRVDLSAVN FPINRDGLRV LYDLPSYPWN HEHGYWAEPR LNKEHRLRKQ
KHHDLLGSPL IGGNALSPTW RHIIRVSDTP WLRAHKVQNN IIYPGAGYIC MAIEAVSQLS
RGQGHTISSL SLKDVEILKA LIVPDTGAGV EVHLTLHEGS EKALTGQPWQ EFHVYSCDDT
GKWSEHCKGF IARNQGNDAY KKNANSDDEV YLRRLNPQEL YRTLQAKGIY HGDVFQNLVS
IQSNRGRSLC TLRVADTASS MPHGVEQPHV LHPTTLDSIF QAVYCSLPTS ALRSNAAMVP
RAFKRMDLRT VMSSTPGHVF QSQCMLHRAS PQGMESSVVV SDTTSEDPVL TVDGLYYQSL
GAAPQADGEK NDIQHNYTLQ WAPDISFPIP STVKAALQFA ANLDEIDIIH DIREACFYFI
RRALATLTED RVLKLNWHQQ RLRAWMKVQI KLAQLNELGP ASSEWFIQPL AHQQNLINRV
RVASVDGEMV CRIGENLPLI LSNEVAPLQL MLKDDLLSEY YARAALREQD APGPHYRCAS
YDFTDISSGF FEAASERFKE AGDVMEFKKL NIEEDPSGQG FESNSYDLVI ASQVLHATKN
INRTLANVRK LLRPGGKLLL VEITRDEIDL QLIFGTLPGW WLGEEAERQS SPSLTIPEWQ
IAMKSTGFDG IDMELHDCED EHFYAFSVLL ASAAIPDPVI YPQFTIVYKE MPPTKWLNKL
ITSLEQLTTF KPDVQQLGTF DAEGKTCLFL GEMHEALLHE PSSTEFGSIQ SLLIQAAGVL
WVSRGSAIHC ERPHNSLHTG LLRTLRTEYS SKLLVSLDID PTTARWPASA IATMLEVVRR
RFPLAQDPSH LDNEYAERGG IICVPRVFET DVESSPSTRS IESAETKTEL FRQSSRKLRL
QVSTPGLLDT LGFVGEPMQT DPLPEESIEV EPMAFGLNFR DVMVAMGQLS TDVMGFECSG
VVTQVGSLAS QHGFKIGDRV CALMRGHWEN RVRLHWTSVV AIPDGMTFDA AASIPMAFTT
SYYALYETAR LQLGETVLIH AAAGGVGQAA ITLAQRVGAE VFVTAGSPEK REYLSREFGI
PEDHIFSSRD GEFAARLMEM TAGKGVDVVL NSLAGEFLQR TFNCVAPFGR FVEIGKRDLE
QNKQLEMHAF TRHVSFSSVD LIALGELKGA VVSRIMNDIM RLIKDEGLRL IQPTTTYPIS
RIKEAFRMLQ AGRHIGKVIV IPGPDDRVNL LPSEWSLHLH SESTHLVIGG MGGVGRSICE
WLVQRGARNL IIMSRNADQQ AQGNAYVNSL RASGCTVVVA SCDISDKSDL KRTLDGCLQS
MPPLRGVIHS GMVLQDTVYE KMSVEDYARA IRPKVQGSWN LHEVLSDVDL EYFIMLSSLN
GITGNVSQAN YAAGNTFQDA IARHRSARGL PAVAIDLGMV RGVGYVAETD GVANRLERMG
FRAVDEEEVL HLIQDAILHP IRHATDSQIL TGFNSHPGAG NTNVFWAKDP ILGGVLRATG
IKSKTRSNRV HDAMDLREQL ANVPLPDDRL VVLQTAIVRK LAAMFFVDDE TIQVGESLAR
YGVDSLVAVE LRNWLVVQLA IEVSIFDIMQ SASVKQLASS LAAKWAAAAA
//