ID Q5CPP8_CRYPI Unreviewed; 682 AA.
AC Q5CPP8;
DT 12-APR-2005, integrated into UniProtKB/TrEMBL.
DT 12-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=Heat shock 70 kDa protein {ECO:0000256|ARBA:ARBA00018181};
DE Flags: Fragment;
GN ORFNames=cgd2_20 {ECO:0000313|EMBL:EAK87398.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK87398.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAK87398.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
RN [2] {ECO:0007829|PDB:3KVG}
RP X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 15-396 IN COMPLEX WITH ATPANALOG.
RG Structural Genomics Consortium (SGC);
RA Wernimont A.K., Hutchinson A., Sullivan H., Lew J., Bochkarev A.,
RA Arrowsmith C.H., Bountra C., Weigelt J., Edwards A.M., Hui R.,
RA Pizarro J.C., Hills T.;
RT "Crystal structure of the N-terminal domain of Hsp70 (cgd2_20) from
RT Cryptosporidium parvum in complex with AMPPNP.";
RL Submitted (NOV-2009) to the PDB data bank.
RN [3] {ECO:0007829|PDB:3L4I}
RP X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 15-396 IN COMPLEX WITH ADP.
RA Pizarro J.C., Wernimont A.K., Hutchinson A., Sullivan H., Lew J.,
RA Bochkarev A., Arrowsmith C.H., Bountra C., Weigelt J., Edwards A.M.,
RA Hui R., Hills T.;
RT "CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HSP70 (CGD2_20) FROM
RT Cryptosporidium PARVUM IN COMPLEX WITH ADP and inorganic phosphate.";
RL Submitted (DEC-2009) to the PDB data bank.
RN [4] {ECO:0007829|PDB:3L6Q}
RP X-RAY CRYSTALLOGRAPHY (2.29 ANGSTROMS) OF 15-396 IN COMPLEX WITH MG(2+).
RG Structural Genomics Consortium (SGC);
RA Pizarro J.C., Wernimont A.K., Hutchinson A., Sullivan H., Lew J.,
RA Bochkarev A., Arrowsmith C.H., Bountra C., Weigelt J., Edwards A.M.,
RA Hui R., Hills T.;
RT "Crystal structure of the N-terminal domain of HSP70 from Cryptosporidium
RT parvum (CGD2_20).";
RL Submitted (DEC-2009) to the PDB data bank.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|RuleBase:RU003322}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAK87398.1}.
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DR EMBL; AAEE01000013; EAK87398.1; -; Genomic_DNA.
DR RefSeq; XP_625373.1; XM_625373.1.
DR PDB; 3KVG; X-ray; 2.15 A; A/B=15-396.
DR PDB; 3L4I; X-ray; 2.20 A; A/B=15-396.
DR PDB; 3L6Q; X-ray; 2.29 A; A/B=15-396.
DR PDBsum; 3KVG; -.
DR PDBsum; 3L4I; -.
DR PDBsum; 3L6Q; -.
DR AlphaFoldDB; Q5CPP8; -.
DR SMR; Q5CPP8; -.
DR STRING; 353152.Q5CPP8; -.
DR EnsemblProtists; EAK87398; EAK87398; cgd2_20.
DR GeneID; 3372348; -.
DR KEGG; cpv:cgd2_20; -.
DR InParanoid; Q5CPP8; -.
DR OMA; KANPIMM; -.
DR OrthoDB; 3028330at2759; -.
DR EvolutionaryTrace; Q5CPP8; -.
DR Proteomes; UP000006726; Chromosome 2.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR CDD; cd10233; HSPA1-2_6-8-like_NBD; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR19375:SF395; HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3KVG, ECO:0007829|PDB:3L4I};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW Metal-binding {ECO:0007829|PDB:3L6Q};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003322};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726};
KW Stress response {ECO:0000313|EMBL:EAK87398.1}.
FT REGION 657..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 25
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:3L4I"
FT BINDING 25
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0007829|PDB:3L6Q"
FT BINDING 26
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:3L4I"
FT BINDING 214
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:3L4I"
FT BINDING 281
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:3L4I"
FT BINDING 284
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:3L4I"
FT BINDING 288
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:3L4I"
FT BINDING 352
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:3L4I"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAK87398.1"
SQ SEQUENCE 682 AA; 74457 MW; B9F5CE62B0948B7C CRC64;
ILIEIQKNKM TSSEGPAIGI DLGTTYSCVG VWRNDTVDIV PNDQGNRTTP SYVAFTETER
LIGDAAKNQV ARNPENTVFD AKRLIGRKFD DQAVQSDMTH WPFKVVRGPK DKPIISVNYL
GEKKEFHAEE ISAMVLQKMK EISEAYLGRQ IKNAVVTVPA YFNDSQRQAT KDAGAIAGLN
VMRIINEPTA AAIAYGLDKK GTGERNVLIF DLGGGTFDVS LLTIEDGIFE VKATAGDTHL
GGEDFDNRLV EFCVQDFKRK NRGMDLTTNA RALRRLRTQC ERAKRTLSSS TQATIELDSL
YEGIDYSVAI SRARFEELCA DYFRATLAPV EKVLKDAGMD KRSVHDVVLV GGSTRIPKVQ
ALIQEFFNGK EPCKAINPDE AVAYGAAVQA AILNGEQSSA VQDLLLLDVA PLSLGLETAG
GVMTKLIERN TTIPAKKTQV FTTYADNQSG VLIQVYEGER AMTKDNHLLG KFHLDGIPPA
PRGVPQIEVT FDIDANGILN VSAVDKSTGK SSKITITNDK GRLSKDDIER MVNDAEKYKG
EDEQNRLKIE AKNSLENYLY NMRNTIQEPK VKEKLSQSEI DEAEKKIKDA LDWLEHNQTA
EKDEFEHQQK EIETHMNPLM MKIYSAEGGM PGGMPGGMPG GMPGGMPGGM PGGMPGGMPG
GMPGGMPGGM PGSNGPTVEE VD
//