ID Q5CPV0_CRYPI Unreviewed; 351 AA.
AC Q5CPV0;
DT 12-APR-2005, integrated into UniProtKB/TrEMBL.
DT 12-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Archeo-eukaryotic exosomal RNAse {ECO:0000313|EMBL:EAK87443.1};
GN ORFNames=cgd4_3930 {ECO:0000313|EMBL:EAK87443.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK87443.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAK87443.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- SIMILARITY: Belongs to the RNase PH family.
CC {ECO:0000256|ARBA:ARBA00006678}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAK87443.1}.
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DR EMBL; AAEE01000012; EAK87443.1; -; Genomic_DNA.
DR RefSeq; XP_625414.1; XM_625414.1.
DR AlphaFoldDB; Q5CPV0; -.
DR STRING; 353152.Q5CPV0; -.
DR EnsemblProtists; EAK87443; EAK87443; cgd4_3930.
DR GeneID; 3372428; -.
DR KEGG; cpv:cgd4_3930; -.
DR VEuPathDB; CryptoDB:cgd4_3930; -.
DR InParanoid; Q5CPV0; -.
DR OMA; ECRINTH; -.
DR OrthoDB; 202892at2759; -.
DR Proteomes; UP000006726; Chromosome 4.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR11953; EXOSOME COMPLEX COMPONENT; 1.
DR PANTHER; PTHR11953:SF0; EXOSOME COMPLEX COMPONENT RRP41; 1.
DR Pfam; PF01138; RNase_PH; 1.
DR SUPFAM; SSF55666; Ribonuclease PH domain 2-like; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 32..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 108..240
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF01138"
SQ SEQUENCE 351 AA; 40312 MW; 96D5DB82ACD6E420 CRC64;
MNNLIVWIFL IHKNLTYFFL FQINFGKSGL KISIFAFITF KAKFINLFFF FFFFLTEKKG
IGYLFFFFKN YKFFFLRKFF FFFQIKKKMN EIVNKHGIRQ DGRKLTEIRR IKCIINEGNQ
RGIEDGNVYF EQGQNKLIVS IVGPVPISGN INYTNNNSGV QINCNFRVSP FSSQDRRKRG
KNDRFCIESG LIISRTFSSV ICDQYSKSQI IINIIILEGD GSVRSAAINA TSIALAISGI
SMKDLIVSAT CGLYGKQVLY DLTQSEMESL KGTLLMAIHS TDNDIDTDTE NVGNGNSDIS
PVTIDLNTKL KPEMIEFLMN ETFSACKQFS VIIRDFLKNY TCNKYQSIYS K
//
