ID Q5CQB8_CRYPI Unreviewed; 819 AA.
AC Q5CQB8;
DT 12-APR-2005, integrated into UniProtKB/TrEMBL.
DT 12-APR-2005, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE SubName: Full=NADPH-dependent FMN FAD containing oxidoreductase {ECO:0000313|EMBL:EAK87715.1};
DE Flags: Fragment;
GN ORFNames=cgd4_1330 {ECO:0000313|EMBL:EAK87715.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK87715.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAK87715.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAK87715.1}.
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DR EMBL; AAEE01000009; EAK87715.1; -; Genomic_DNA.
DR RefSeq; XP_625730.1; XM_625730.1.
DR AlphaFoldDB; Q5CQB8; -.
DR STRING; 353152.Q5CQB8; -.
DR EnsemblProtists; EAK87715; EAK87715; cgd4_1330.
DR GeneID; 3372615; -.
DR KEGG; cpv:cgd4_1330; -.
DR InParanoid; Q5CQB8; -.
DR OMA; DIMSIPR; -.
DR OrthoDB; 276396at2759; -.
DR Proteomes; UP000006726; Chromosome 4.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384:SF10; NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726}.
FT DOMAIN 18..180
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAK87715.1"
SQ SEQUENCE 819 AA; 97838 MW; 8898E8BBD5B36D79 CRC64;
ILFRTNIIKT KMKCPKRVWI VYASQTGKSE RLSYDIRDEL WKIGVIGYPT SIDQFEHIFF
DYFEEENEEN VDKKSEIEFP MIIFVLSTTG QGEVPDTMVS FWNRILLNNL NTKLIKKMNF
TIFGMGDRCF GNERFNITAR KLRHLLLNYG AIEKIPWGLG DESHDFGILG EYDPWIENII
KMFTSNLQID DYFKINILPI NKYKCEIIDI HPEKQINYEF DMELDYELKN SLNIQKKHVT
DMNRKSISFP TISNVLYNQE CDKESKNRRI KKIKFGLSNQ DQIHYKSGTH IAVWPVNPIE
KVLQFIDLFN KKINPKTIIK IQFNDNYYNC LCNQLDECEY KIQNDHLNLN KFKQCYIENQ
EYKINSHFPL NEKISIFTLI YRYLDIMNIP ERRFVNQCYY NTSHDMHKQR LNEMIQKTVD
SKKDYCDYIK DEHRNYIELL WDFNSIQLEI DVIINYIPII IPRYYSICNT KNWYKFNLWR
YIEYEEYIRK NSIGFSHNNE LILPEIFSNI LGILLPKIQI NSNNYYNIFK TLRSKVINNY
FIKAKENYLN NIMKEYKNIS YHQKYGYLNY HHIIEICVDI IEWNTVYNRK IRGLCSGYLD
DVILNQKTLI AFENKITNEI HKELVDPKIP VLLISCGLGI TGIISILQER IFNIMLKPKF
NNEKEITNNT LVYIGLRYSN VMYPYIDQIN EFSRRKELIN QVKFNISYSR KNPDIQESIF
NNHSSENHQV VNLNHLKSGC YIQSLLLSDE DDNMRDYIVN CILNGYILIC GNALTMPMEI
RETLAKILVL QGKFDKIEDS LIYIKKLIRY GRYIEETWV
//
