ID Q5CQX6_CRYPI Unreviewed; 694 AA.
AC Q5CQX6;
DT 12-APR-2005, integrated into UniProtKB/TrEMBL.
DT 12-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Aminopeptidase {ECO:0000313|EMBL:EAK87928.1};
DE Flags: Fragment;
GN ORFNames=cgd4_2910 {ECO:0000313|EMBL:EAK87928.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK87928.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAK87928.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAK87928.1}.
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DR EMBL; AAEE01000008; EAK87928.1; -; Genomic_DNA.
DR RefSeq; XP_625876.1; XM_625876.1.
DR AlphaFoldDB; Q5CQX6; -.
DR STRING; 353152.Q5CQX6; -.
DR EnsemblProtists; EAK87928; EAK87928; cgd4_2910.
DR GeneID; 3372972; -.
DR KEGG; cpv:cgd4_2910; -.
DR InParanoid; Q5CQX6; -.
DR OMA; EPGMILS; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000006726; Chromosome 4.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:EAK87928.1};
KW Hydrolase {ECO:0000313|EMBL:EAK87928.1};
KW Protease {ECO:0000313|EMBL:EAK87928.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726}.
FT DOMAIN 21..141
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 377..602
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 617..679
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAK87928.1"
SQ SEQUENCE 694 AA; 79336 MW; 42FE911526707013 CRC64;
ALHLIKITLP IMSNISKLKK LEELRSIMSQ HGVDAYIISS SDPHMSEYTP DKYKRREFMT
GFSGSQGICL VTQSSAHLIV DGRYIVEAKK TATPEYQVHL LKKGFYADIV DILKEESFDG
TLGIDVEVTS WMSFKALANY IELSDLHLNT NFRIKLLNLN FVDVLRPQEE IEQARSEIFV
HGIEYAGESS KSKVSKVLLE MKKLNAKILF LSSLTQISWL LNLRGSDVHC TPVFLSYLIV
EILDDKVGID KKETSFSLKV FVNVESIKCC EEVLKNEFQD KISIIQIENI MDELFHSFSK
LNSHTKNELN KIWLPENFCN LAAMDTLFKV LNPRENCNNS SYYKYLIDYL NSSKLLITSE
SPIIMLRAIK NKIELKGMRE CHIYDGLALT KFLYYLYKAG RDKTLFNGKV SEWDLSQKLL
EFRKQQPKFV YPSFDTISSI GENGAIIHYR PEKENSSIIK PDLYLCDSGG QYHTGTTDVT
RTLFLFGIGE ERPTIEQIES FTRVLIGFIR LHKLVFPIGT NATAIDVLAR ASLWEAGLDY
LHGTGHGVGS FLSVHEEPWS ICYKVGRDGA SKQNLAAGAV VSIEPGYYEE GKYGIRIENL
AEIIEVDIDN GYRKMNKFLK FSPLTFAPIQ KEMIDISILS DDELDWLNWY HSKTLENLEP
LVDDDPEFLK WLVQACSPIN RYISKIDFPK TLYQ
//
