ID Q5CRA7_CRYPI Unreviewed; 745 AA.
AC Q5CRA7;
DT 12-APR-2005, integrated into UniProtKB/TrEMBL.
DT 12-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=CNcl1p/MJ0026/YebU-like. SUN family methylase {ECO:0000313|EMBL:EAK88233.1};
DE Flags: Fragment;
GN ORFNames=cgd5_3560 {ECO:0000313|EMBL:EAK88233.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK88233.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAK88233.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAK88233.1}.
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DR EMBL; AAEE01000007; EAK88233.1; -; Genomic_DNA.
DR RefSeq; XP_626279.1; XM_626279.1.
DR AlphaFoldDB; Q5CRA7; -.
DR STRING; 353152.Q5CRA7; -.
DR EnsemblProtists; EAK88233; EAK88233; cgd5_3560.
DR GeneID; 3373081; -.
DR KEGG; cpv:cgd5_3560; -.
DR InParanoid; Q5CRA7; -.
DR OMA; DTRRAHM; -.
DR OrthoDB; 197651at2759; -.
DR Proteomes; UP000006726; Chromosome 5.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22808; NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22808:SF1; RNA CYTOSINE C(5)-METHYLTRANSFERASE NSUN2; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 35..439
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT REGION 517..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..536
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 297
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 154..160
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 187
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 243
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAK88233.1"
SQ SEQUENCE 745 AA; 86203 MW; 6FE604008E5691C8 CRC64;
KMSNKGYSDL VKESKLFEKY YKEQNIVPVE EWELFMEYLK QDLPSTFRVV GVSPYSSSIK
EFAKETESVT VYLNENSEEM DNLIKEIKWY PKGLAFQITK SRDKLRRSSG VSKEFHSKLV
MMSDGGSIMR QEAVSMLPVL FLDVKPNHYV LDLCSAPGSK TSQIIEILQS EQAVTGEYPK
GFVIANDLDT RRAHMLIHHT RHLNSPSLIV TTHSADHFPD IYLSNPSSES LKEKFYFDRI
LCDVPCSSDG TLRKNPNLFA KWSISFSLGL HRLQRNILLR ALSILKPKEG LLVYSTCSFN
PLENEAVVSS VISSLANRGI HVEIVDPLTI SEISKDVISK TKFGRGISTW RVPIPRKQLK
KNKNKKNKCE ETNVELLSQE PKEFFDNYEE VPFQSRESIF PSMFPPEDPK IKESLSKCIR
ISPHQENTGG FFVSVLRITS SEKEDHKVDN FQLEIQDDYL TLADNPNKKN IIKMLFNPYG
ISNFNEEKIL NTLIYRNPKG DFNRACTNKK SLEELNKKEK ENKEGSTDKI EDDFDSINNT
TDDLSNQELE DSKFPRKMWQ VSESVSKFLF SAKSKNPLRV IHAGFPGVEL SRYRKGPISI
EDNQIIDVNF PPIYRFNCGF NSYLHYSHGL SLDDTPRCRE FPIKYILKLL QTIEKPTENT
EEVKEFHPYR IPRHHLKEEE YPEFKGIFDL PGSIIIKLDM KKFGGNKPIF LPAHVGRHHI
ELLLDKFLRF CVKFHIEWLY KHQNH
//
