ID Q5CW87_CRYPI Unreviewed; 1150 AA.
AC Q5CW87;
DT 12-APR-2005, integrated into UniProtKB/TrEMBL.
DT 12-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=SEC24C-like component of COPII coatamer of ER-golgi vesicles {ECO:0000313|EMBL:EAK89343.1};
GN ORFNames=cgd8_1250 {ECO:0000313|EMBL:EAK89343.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK89343.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAK89343.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAK89343.1}.
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DR EMBL; AAEE01000003; EAK89343.1; -; Genomic_DNA.
DR RefSeq; XP_627032.1; XM_627032.1.
DR AlphaFoldDB; Q5CW87; -.
DR STRING; 353152.Q5CW87; -.
DR EnsemblProtists; EAK89343; EAK89343; cgd8_1250.
DR GeneID; 3374265; -.
DR KEGG; cpv:cgd8_1250; -.
DR InParanoid; Q5CW87; -.
DR OMA; INPFMTF; -.
DR OrthoDB; 977017at2759; -.
DR Proteomes; UP000006726; Chromosome 8.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR PANTHER; PTHR13803:SF4; SECRETORY 24CD, ISOFORM C; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 313..351
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 397..564
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 687..776
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 846..903
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1150 AA; 127840 MW; 58E6FA81E9172A7C CRC64;
MRVYPNFSTS NYSQNGNSLP VNDIPNQTNN SSSIQSATQQ PNIPQYVQNY SVINNKYNNG
QTNNYLQNAN NQQLNNNHQI QSNTNFTSNI NQSYNYNTYN NPTNSQPQPV QQTTYPPPNN
NSSIPTTGSS YNTAYGSQFP PKHEAKMNNP PMQTSTIAAP HPGSSTQFHQ GQYQTNLQTQ
QQQYQQQQQQ QQHLAENSTN LVTSLTKPVQ SRVDPSQIPR PVFGNIIDKD CCIYESDKYL
LPPNSLAEPH SMLIDRGNAT GKFYKLTLNQ IPSQHSILQS MKLPCAAIIQ PFPLLNDFEN
PVPIVNSSST IEPIRCLRCR AYANPFTCVS QNGSQCLCNF CGHTFDIPMD YLRLLQSQIK
TQSYQSPNDD QNNYPEIYHG VVDYFAPASL GVTTTPELPC YCFVIEASSM ALQGNVTNLI
LYCLKHIFTQ LAQSSPESNV TLILYSREIL LFPYQNLNEN SKPPIKMCVV SDIMEPFLPC
PLSELCVPVA QGLEFLHELI DRIPSLIAPH STPHNAYFSA VSLATQIFKA RNSTGSIFSF
VSSVPNIGFA AINTKETNVA PKSPPRKTSK GMKPSLGFVS GYLVHNIQQL DTMVQACREI
NVSLDTFIVT KIIQGDYSTG EQGQGLTSPN ANAGSAFGAN SVPTSTFAYL SQHTGGKLRL
FTEFPFEKIY RDIYQTLYSI FFVQNVAYDC TFKLRCSRGI AVSKIYAPWT AGGPTPDLSA
FQIPKLDSNT AIAFLLRHEE NLEQRKNVFL QAACLYTCKD KRQRLLRVLT ISIPVTTSIT
TAFRYASIEP IINIYARMAA HHIVSKGQRG FSGSSGSTSV SSTGAIAAAT SVVPGLPFST
NKNSSSILTA WKQETLNSII DMLFSYREHC ANTSSTGQLI LPDSLKLTLI YVSSLFKHPS
LMPLNTVLEF TVSEQLVGLY ELLYASVSFT TATLYPRLYP LHHSLILSES NNELQKLESV
GLPYQLTFQN DSSINTGNNT NNMMGMNASN TSSFQSSDAP IISRYWLNHS IACSGERILS
DGIYVLENGK EIYLYFGPQV DSKVISEIFG VTSINFENFT KLSFPPEDYL PTMESNIGIS
KRISNVVQQI RNDRFSVNCY MPVVIVSPVS QNIEAKFKAM LVEDAYGFET TYVDFLCNVH
KLVQSKIVDS
//
