ID Q5DD62_SCHJA Unreviewed; 288 AA.
AC Q5DD62;
DT 29-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 29-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Caspase 3, apoptosis-related cysteine peptidase {ECO:0000313|EMBL:CAX76585.1};
DE EC=3.4.22.- {ECO:0000313|EMBL:CAX76585.1};
DE SubName: Full=SJCHGC00800 protein {ECO:0000313|EMBL:AAW26244.1};
GN Name=CASP3 {ECO:0000313|EMBL:CAX76585.1};
OS Schistosoma japonicum (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6182 {ECO:0000313|EMBL:AAW26244.1};
RN [1] {ECO:0000313|EMBL:AAW26244.1}
RP NUCLEOTIDE SEQUENCE.
RA Han Z.;
RT "The full-length cDNA sequences of Schistosoma japonicum genes.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAW26244.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16617374; DOI=10.1371/journal.ppat.0020029;
RA Liu F., Lu J., Hu W., Wang S.Y., Cui S.J., Chi M., Yan Q., Wang X.R.,
RA Song H.D., Xu X.N., Wang J.J., Zhang X.L., Zhang X., Wang Z.Q., Xue C.L.,
RA Brindley P.J., McManus D.P., Yang P.Y., Feng Z., Chen Z., Han Z.G.;
RT "New perspectives on host-parasite interplay by comparative transcriptomic
RT and proteomic analyses of Schistosoma japonicum.";
RL PLoS Pathog. 2:268-281(2006).
RN [3] {ECO:0000313|EMBL:CAX76585.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Anhui {ECO:0000313|EMBL:CAX76585.1};
RX DOI=10.1038/nature08140;
RA Liu F., Zhou Y., Wang Z.Q., Lu G., Zheng H., Brindley P.J., McManus D.P.,
RA Blair D., Zhang Q.H., Zhong Y., Wang S., Han Z.G., Chen Z.;
RT "The Schistosoma japonicum genome reveals features of host-parasite
RT interplay.";
RL Nature 460:345-351(2009).
RN [4] {ECO:0000313|EMBL:CAX76585.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Anhui {ECO:0000313|EMBL:CAX76585.1};
RA Gang L.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR EMBL; AY814512; AAW26244.1; -; mRNA.
DR EMBL; FN320859; CAX76585.1; -; mRNA.
DR EMBL; FN320860; CAX76586.1; -; mRNA.
DR EMBL; FN320862; CAX76588.1; -; mRNA.
DR AlphaFoldDB; Q5DD62; -.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00032; CASc; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR10454; CASPASE; 1.
DR PANTHER; PTHR10454:SF31; CASPASE-7; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 2: Evidence at transcript level;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CAX76585.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 44..168
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 185..282
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
SQ SEQUENCE 288 AA; 32675 MW; 43CDFDC00ED27A08 CRC64;
MGESNPTDEK HVNKGSYLSV STDDLHNPYF SYPVVSPDRP GQFYRGECLL INQRDFDPST
NQSKRNGTDI DADRIERVFR SLNYKVTRIL NITKKALDQT LIEASQKDHS SYDSFVFVML
THGDKDVVYA SDDEVQTSYI MSFFRGDRCP SLIGKPKLFF FQACRGVSFD KGVSTMVADA
GDDVIVRKLP VEADILVSYS TVPGYFAWRN STKGSWYIQE LCNALETDIK NGNHTDIMTL
LTVVARVVAY QYRSSTRQVE TDNMKQMTST FSTLTRLFHI TGPPKEIK
//
