ID Q5EAP6_DANRE Unreviewed; 219 AA.
AC Q5EAP6;
DT 15-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Death ligand 3 {ECO:0000313|RefSeq:NP_001013301.1};
DE SubName: Full=Tumor necrosis factor (Ligand) superfamily, member 10 like 4 {ECO:0000313|EMBL:AAH90312.1};
GN Name=tnfsf10l4 {ECO:0000313|EMBL:AAH90312.1,
GN ECO:0000313|RefSeq:NP_001013301.1,
GN ECO:0000313|ZFIN:ZDB-GENE-050227-6};
GN Synonyms=zgc:113297 {ECO:0000313|RefSeq:NP_001013301.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH90312.1};
RN [1] {ECO:0000313|EMBL:AAH90312.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Singapore local strain {ECO:0000313|EMBL:AAH90312.1};
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH90312.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001013301.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001013301.1};
RX PubMed=16888647; DOI=10.1038/sj.cdd.4402015;
RA Eimon P.M., Kratz E., Varfolomeev E., Hymowitz S.G., Stern H., Zha J.,
RA Ashkenazi A.;
RT "Delineation of the cell-extrinsic apoptosis pathway in the zebrafish.";
RL Cell Death Differ. 13:1619-1630(2006).
RN [3] {ECO:0000313|RefSeq:NP_001013301.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001013301.1};
RX PubMed=21527275;
RA Wiens G.D., Glenney G.W.;
RT "Origin and evolution of TNF and TNF receptor superfamilies.";
RL Dev. Comp. Immunol. 35:1324-1335(2011).
RN [4] {ECO:0000313|RefSeq:NP_001013301.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001013301.1};
RX PubMed=23118857; DOI=10.1371/journal.pone.0046642;
RA Micale L., Loviglio M.N., Manzoni M., Fusco C., Augello B., Migliavacca E.,
RA Cotugno G., Monti E., Borsani G., Reymond A., Merla G.;
RT "A fish-specific transposable element shapes the repertoire of p53 target
RT genes in zebrafish.";
RL PLoS ONE 7:e46642-e46642(2012).
RN [5] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6] {ECO:0000313|RefSeq:NP_001013301.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001013301.1};
RX PubMed=24683187;
RA Briolat V., Jouneau L., Carvalho R., Palha N., Langevin C., Herbomel P.,
RA Schwartz O., Spaink H.P., Levraud J.P., Boudinot P.;
RT "Contrasted innate responses to two viruses in zebrafish: insights into the
RT ancestral repertoire of vertebrate IFN-stimulated genes.";
RL J. Immunol. 192:4328-4341(2014).
RN [7] {ECO:0000313|RefSeq:NP_001013301.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001013301.1};
RX PubMed=25792259;
RA Biswas G., Kinoshita S., Kono T., Hikima J., Sakai M.;
RT "Evolutionary evidence of tumor necrosis factor super family members in the
RT Japanese pufferfish (Takifugu rubripes): Comprehensive genomic
RT identification and expression analysis.";
RL Mar. Genomics 22:25-36(2015).
RN [8] {ECO:0000313|RefSeq:NP_001013301.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001013301.1};
RX PubMed=30755680;
RA Huang L., Urasaki A., Inagaki N.;
RT "Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in
RT the zebrafish brain.";
RL Sci. Rep. 9:1799-1799(2019).
RN [9] {ECO:0000313|RefSeq:NP_001013301.1}
RP IDENTIFICATION.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001013301.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; BC090312; AAH90312.1; -; mRNA.
DR RefSeq; NP_001013301.1; NM_001013283.1.
DR GeneID; 503595; -.
DR KEGG; dre:503595; -.
DR AGR; ZFIN:ZDB-GENE-050227-6; -.
DR CTD; 503595; -.
DR ZFIN; ZDB-GENE-050227-6; tnfsf10l4.
DR OrthoDB; 5341885at2759; -.
DR PhylomeDB; Q5EAP6; -.
DR Proteomes; UP000000437; Alternate scaffold 5.
DR Proteomes; UP000000437; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11471:SF27; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10; 1.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 67..218
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 219 AA; 24915 MW; CDB916C8FF1A2B16 CRC64;
MVVDEGFPIH CLSTNLSQPA DQAGITSCDL FNQELKQTAH QRLLLDIQNY LLETFGDHNI
TEIFKPAVHV GAKQELKQYQ SLQINDEVPA LDRIHWDNMN GQFIQEGLMR LSPDGEIVVP
LNGIYFVFSQ VNFETQLGQN VHFTQYLYKR TASYPRPVML SKAAVTPCSS VRSGVQLYTN
HQGALFRLQK GDRLSLYVLD TRAVRFPQEA TYFGAFMIK
//
