ID Q5EFE0_CHICK Unreviewed; 419 AA.
AC Q5EFE0; F1P1J8;
DT 15-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Gonadotropin releasing hormone receptor 2 {ECO:0000313|EMBL:AAW80968.1};
DE SubName: Full=Type 1/III gonadotropin-releasing hormone receptor {ECO:0000313|EMBL:ABK27709.1};
GN Name=GNRHR1/III {ECO:0000313|EMBL:ABK27709.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AAW80968.1};
RN [1] {ECO:0000313|EMBL:AAW80968.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16870947; DOI=10.1095/biolreprod.105.050252;
RA Shimizu M., Bedecarrats G.Y.;
RT "Identification of a novel pituitary-specific chicken gonadotropin-
RT releasing hormone receptor and its splice variants.";
RL Biol. Reprod. 75:800-808(2006).
RN [2] {ECO:0000313|EMBL:ABK27709.1}
RP NUCLEOTIDE SEQUENCE.
RA Ikemoto T., Park M.K.;
RT "Identification and molecular characterization of a second GnRH receptor
RT gene in the chicken.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AY895154; AAW80968.1; -; mRNA.
DR EMBL; DQ889867; ABK27709.1; -; mRNA.
DR RefSeq; NP_001012627.1; NM_001012609.1.
DR AlphaFoldDB; Q5EFE0; -.
DR SMR; Q5EFE0; -.
DR GeneID; 427517; -.
DR KEGG; gga:427517; -.
DR VEuPathDB; HostDB:LOC427517; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_15_2_1; -.
DR OMA; GWGCPCR; -.
DR OrthoDB; 4815971at2759; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0016500; F:protein-hormone receptor activity; IEA:InterPro.
DR CDD; cd15383; 7tmA_GnRHR_vertebrate; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001658; GphnRH_fam_rcpt.
DR PANTHER; PTHR24241:SF69; GONADOTROPIN-RELEASING HORMONE II RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00529; GNADOTRPHINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:AAW80968.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 66..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 83..349
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 45475 MW; 4A45D531B63C68D0 CRC64;
MARLGGGTGQ DAAAAGGGWL DPGPTVGNVS TEPSSSTSHP KRGCAWSPRL ESAEEPLLLP
TFSPAAQARV AATFVLFVLS AGCNVAVLRA AGGRRGGGRS HIRVLLRHLA AADLLVTVVV
MPLDAIWNIT LQWRAGDLAC RLLMYLRLLA MYASAFVTVV ISLDRQAAIL RPLAIARARC
RNRAMLRAAW MLSAALAVPQ LFLFHTVTLH APHNFTQCTT HGSFPQPWHE TLYNMLSFSC
LFLLPLLIMV CCYTRILLEI SRRMGSSLFS SRDVPLRCSG SNIPRARLRT LKMSLVIVSS
FILCWTPYYL LGLWYWFCPR AMQQKVPPSL SHILFIFGLF NACLDPITYG LFTIPFRRRC
GCPCGHSSEP EPPSPATGSF HCSASSLRGR QGMGGTEGPH PPIELGLPTG AGSCQSSAL
//
