ID   Q5EIP3_PLAFA            Unreviewed;       539 AA.
AC   Q5EIP3;
DT   15-MAR-2005, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2005, sequence version 1.
DT   22-FEB-2023, entry version 39.
DE   SubName: Full=Thrombospondin-related adhesive protein {ECO:0000313|EMBL:AAW78165.1};
DE   Flags: Fragment;
OS   Plasmodium falciparum (malaria parasite P. falciparum).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5833 {ECO:0000313|EMBL:AAW78165.1};
RN   [1] {ECO:0000313|EMBL:AAW78165.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=E11 {ECO:0000313|EMBL:AAW78165.1};
RX   PubMed=17046771; DOI=10.1016/j.ijpara.2006.09.001;
RA   Weedall G.D., Preston B.M., Thomas A.W., Sutherland C.J., Conway D.J.;
RT   "Differential evidence of natural selection on two leading sporozoite stage
RT   malaria vaccine candidate antigens.";
RL   Int. J. Parasitol. 37:77-85(2007).
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DR   EMBL; AY878585; AAW78165.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5EIP3; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   CDD; cd01471; vWA_micronemal_protein; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR16059; ANTHRAX TOXIN RECEPTOR; 1.
DR   PANTHER; PTHR16059:SF25; THROMBOSPONDIN-RELATED ANONYMOUS PROTEIN; 1.
DR   Pfam; PF00090; TSP_1; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00209; TSP1; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50092; TSP1; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..539
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004256111"
FT   DOMAIN          48..234
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          280..496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..312
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        363..405
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        442..494
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         539
FT                   /evidence="ECO:0000313|EMBL:AAW78165.1"
SQ   SEQUENCE   539 AA;  60865 MW;  DB70465BF1CBEEDE CRC64;
     MNHLGNVKYL VIVFLIFFDL FLVNGRDVQN NIVDEIKYRE EVCNDEVDLY LLMDCSGSIR
     RHNWVNHAVP LAMKLIQQLN LNDNAIHLYA NVFSNNAREI IRLHSDASKN KEKALIIIKS
     LLNTNLPFGR TNLSDALLQV RKHLNDRINR ENANQLVVIL TDGIPDSIQD SLKESRKLND
     LGVKIAVFGI GQGINVAFNR FLVGCHPSDG KCNLYADSAW ENVKNVIGPF MKAVCVEVEK
     TASCGVWDEW SPCSVTCGKG TRSRKREILH EGCTSELQEQ CEEERCPPKW EPLDVPQEPE
     DDQPRPRGDN FAVQKPKENI IDNNPQEPSP NPEEGKDENP NGFDLDENPE NPPNPDIPQQ
     EPNIPEDSEK EVPSDVPKNP EDDREENFDI PKKPENKHDN QNNLPNDKSD RNIPYSPLPP
     KVLDNERKQS DPQSQDNNGN RHVPNSEDRE TRPHGRNNEN RSYNRKYNDT PKHPEREEHE
     KPDNNKKKGE SDNKYKIAGG IAGGLALLAC AGLAYKFVVP GAATPYAGEP APFDETLGE
//