ID Q5EIQ0_PLAFA Unreviewed; 542 AA.
AC Q5EIQ0;
DT 15-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2005, sequence version 1.
DT 22-FEB-2023, entry version 38.
DE SubName: Full=Thrombospondin-related adhesive protein {ECO:0000313|EMBL:AAW78158.1};
DE Flags: Fragment;
OS Plasmodium falciparum (malaria parasite P. falciparum).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5833 {ECO:0000313|EMBL:AAW78158.1};
RN [1] {ECO:0000313|EMBL:AAW78158.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=D6 {ECO:0000313|EMBL:AAW78158.1};
RX PubMed=17046771; DOI=10.1016/j.ijpara.2006.09.001;
RA Weedall G.D., Preston B.M., Thomas A.W., Sutherland C.J., Conway D.J.;
RT "Differential evidence of natural selection on two leading sporozoite stage
RT malaria vaccine candidate antigens.";
RL Int. J. Parasitol. 37:77-85(2007).
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DR EMBL; AY878578; AAW78158.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5EIQ0; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd01471; vWA_micronemal_protein; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR16059; ANTHRAX TOXIN RECEPTOR; 1.
DR PANTHER; PTHR16059:SF25; THROMBOSPONDIN-RELATED ANONYMOUS PROTEIN; 1.
DR Pfam; PF00090; TSP_1; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..542
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004255000"
FT DOMAIN 48..234
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 284..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..363
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..497
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 542
FT /evidence="ECO:0000313|EMBL:AAW78158.1"
SQ SEQUENCE 542 AA; 61049 MW; 4764D85EF35AF6FC CRC64;
MNHLGNVKYL VIVFLIFFDL FLVNGRDVQN NIVDEIKYLE EVCNDQVDLY LLMDCSGSIR
RHNWVKHAVP LAMKLIQQLN LNDNAIHLYV NVFSNNAKEI IRLHSDASKN KEKALIIIKS
LLSTNLPYGK TNLTDALLQV RKHLNDRINR ENANQLVVIL TDGIPDSIQD SLKESRKLND
LGVKIAVFGI GQGINVAFNR FLVGCHPSDG KCNLYADSAW ENVKNVIGPF MKAVCVEVEK
TASCGVWDEW SPCSVTCGKG TRSRKREILH EGCTSELKEQ CEEERCPPKW EPLDVPDEPE
DDQPRPRGDN FAVEKPEENI IDNNPQEPSP NPEEGKGENP NGFDLDENPE NPPNPPNPDI
PEQKPNIPED SEKEVPSDVP KNPEDDREEN FDIPKKPENK HDNQNNLPND KSDRNIPYSP
LPPKVLDNER KQSDPQSQDN NGNRHVPNSE DRETRPHGRN NENRSYNRKY NDTPKHPERE
EHEKPDNNKK KGESDNKYKI AGGIAGGLAL LACAGLAYKF VVPGAATPYA GEPAPFDETL
GE
//
