ID Q5EIR0_PLAFA Unreviewed; 539 AA.
AC Q5EIR0;
DT 15-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2005, sequence version 1.
DT 22-FEB-2023, entry version 36.
DE SubName: Full=Thrombospondin-related adhesive protein {ECO:0000313|EMBL:AAW78148.1};
DE Flags: Fragment;
OS Plasmodium falciparum (malaria parasite P. falciparum).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5833 {ECO:0000313|EMBL:AAW78148.1};
RN [1] {ECO:0000313|EMBL:AAW78148.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C8 {ECO:0000313|EMBL:AAW78148.1};
RX PubMed=17046771; DOI=10.1016/j.ijpara.2006.09.001;
RA Weedall G.D., Preston B.M., Thomas A.W., Sutherland C.J., Conway D.J.;
RT "Differential evidence of natural selection on two leading sporozoite stage
RT malaria vaccine candidate antigens.";
RL Int. J. Parasitol. 37:77-85(2007).
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DR EMBL; AY878568; AAW78148.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5EIR0; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd01471; vWA_micronemal_protein; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR16059; ANTHRAX TOXIN RECEPTOR; 1.
DR PANTHER; PTHR16059:SF25; THROMBOSPONDIN-RELATED ANONYMOUS PROTEIN; 1.
DR Pfam; PF00090; TSP_1; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..539
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004256115"
FT DOMAIN 48..234
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 280..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 539
FT /evidence="ECO:0000313|EMBL:AAW78148.1"
SQ SEQUENCE 539 AA; 60667 MW; 9B15768F19516338 CRC64;
MNHLGNVKYL VIVFLIFFDL FLVNGRDVQN NIVDEIKYRE EVCNDQVDLY LLMDCSGSIR
RHNWVNHAVP LAMKLIQQLN LNDNAIHLYV NVFSNNAREI IRLHSDASKN KEKALIIIKS
LLSTNLPYGR TNLTDALLQV RKHLNDRINR ENANQLVVIL TDGIPDSIQD SLKESRKLND
LGVKIAVFGI GQGINVAFNR FLVGCHPSDG KCNLYADSAW ENVKNVIGPF MKAVCVEVEK
TASCGVWDEW SPCSVTCGKG TRSRKREILH EGCTSEIQEQ CEEERCPPKW EPLDVPDEPE
DDQPRPRGDN SAVQEPEENI IDNNPQEPSP NPEEGKGENP NGFDLDENPE NPPNPDIPQQ
EPNIPEDSEK EVPSDVPKNP EDDREENFDI PKKPENKHDN QNNLPNDKSD RNIPYSPLPP
KVLDNERKQS DPQSQDNNGN RHVPNSEDRE TRPHGRNNEN RSYNRKHNDT PKHPEREEHE
KPDNNKKKGG SDNKYKIAGG IAGGLALLAC AGLAYKFVVP GAATPYAGEP APFDETLGE
//
