ID Q5ENX9_ACIBA Unreviewed; 271 AA.
AC Q5ENX9;
DT 15-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE RecName: Full=Dihydropteroate synthase {ECO:0000256|ARBA:ARBA00012458, ECO:0000256|RuleBase:RU361205};
DE Short=DHPS {ECO:0000256|RuleBase:RU361205};
DE EC=2.5.1.15 {ECO:0000256|ARBA:ARBA00012458, ECO:0000256|RuleBase:RU361205};
DE AltName: Full=Dihydropteroate pyrophosphorylase {ECO:0000256|RuleBase:RU361205};
GN Name=sulII {ECO:0000313|EMBL:AAW84261.1};
GN Synonyms=folP_2 {ECO:0000313|EMBL:SST30056.1}, sul2
GN {ECO:0000313|EMBL:AEZ06044.1}, sulI2 {ECO:0000313|EMBL:AFV47959.1};
GN ORFNames=A0141_RS19395 {ECO:0000313|EMBL:EHU2486398.1}, A0141_RS21335
GN {ECO:0000313|EMBL:EHU2486781.1}, A7M90_18820
GN {ECO:0000313|EMBL:OIG72672.1}, ACX61_00615
GN {ECO:0000313|EMBL:AKQ28957.1}, ACX61_19295
GN {ECO:0000313|EMBL:AKQ32545.1}, ACX61_19525
GN {ECO:0000313|EMBL:AKQ32584.1}, APD17_01730
GN {ECO:0000313|EMBL:KQD50744.1}, AUO97_06030
GN {ECO:0000313|EMBL:APP30398.1}, AYR68_17695
GN {ECO:0000313|EMBL:AML68795.1}, CAS83_19910
GN {ECO:0000313|EMBL:OTT16585.1}, CBE85_18705
GN {ECO:0000313|EMBL:OWK65020.1}, CSB70_0604
GN {ECO:0000313|EMBL:AVI34594.1}, D8O08_015020
GN {ECO:0000313|EMBL:QBF37636.1}, D8O08_015335
GN {ECO:0000313|EMBL:QBF37674.1}, EGM95_01355
GN {ECO:0000313|EMBL:AYY87521.1}, F2P40_20265
GN {ECO:0000313|EMBL:MQR51623.1}, F4T85_20445
GN {ECO:0000313|EMBL:MQZ70700.1}, FE003_13530
GN {ECO:0000313|EMBL:QCT16708.1}, FJU42_19755
GN {ECO:0000313|EMBL:TPU60079.1}, G3N53_19805
GN {ECO:0000313|EMBL:NDW43308.1}, GNY86_12590
GN {ECO:0000313|EMBL:MVM92360.1}, HB367_14080
GN {ECO:0000313|EMBL:QJG84996.1}, HB367_19300
GN {ECO:0000313|EMBL:QJG86150.1}, HB367_19925
GN {ECO:0000313|EMBL:QJG86260.1}, HBK86_21150
GN {ECO:0000313|EMBL:QJH23874.1}, HBK86_21350
GN {ECO:0000313|EMBL:QJH23905.1}, ITE13_20115
GN {ECO:0000313|EMBL:MBP4961777.1}, SAMEA104305318_03424
GN {ECO:0000313|EMBL:SST30056.1};
OS Acinetobacter baumannii.
OG Plasmid pAB04-1 {ECO:0000313|EMBL:AKQ32545.1,
OG ECO:0000313|Proteomes:UP000036348},
OG Plasmid pD4 {ECO:0000313|EMBL:ALG88329.1},
OG Plasmid pPM193665_1 {ECO:0000313|EMBL:QJG86150.1},
OG Plasmid pVB82_1 {ECO:0000313|EMBL:QJH23874.1},
OG Plasmid ppm193665_1 {ECO:0000313|Proteomes:UP000503033},
OG Plasmid pvb82_1 {ECO:0000313|Proteomes:UP000502990},
OG Plasmid unnamed {ECO:0000313|EMBL:ALU33477.1}, and
OG Plasmid unnamed1 {ECO:0000313|EMBL:QBF37636.1,
OG ECO:0000313|Proteomes:UP000270202}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX NCBI_TaxID=470 {ECO:0000313|EMBL:AAW84261.1};
RN [1] {ECO:0000313|EMBL:AAW84261.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RAM {ECO:0000313|EMBL:AAW84261.1};
RX PubMed=15686845; DOI=10.1016/j.femsle.2005.01.005;
RA Segal H., Garny S., Elisha B.G.;
RT "Is IS(ABA-1) customized for Acinetobacter?";
RL FEMS Microbiol. Lett. 243:425-429(2005).
RN [2] {ECO:0000313|EMBL:CAX63188.1}
RP NUCLEOTIDE SEQUENCE.
RA Ferreira S., Li H.Y., Toleman M., Mendo S., Walsh T.;
RT "Characterization of ISCR2 in Acinetobacter baumanii from Portugal and
RT Argentina.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AEZ06044.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A91 {ECO:0000313|EMBL:AEZ06044.1};
RX PubMed=22351684; DOI=10.1093/jac/dks037;
RA Nigro S.J., Hall R.M.;
RT "Tn6167, an antibiotic resistance island in an Australian carbapenem-
RT resistant Acinetobacter baumannii GC2, ST92 isolate.";
RL J. Antimicrob. Chemother. 67:1342-1346(2012).
RN [4] {ECO:0000313|EMBL:AGR54514.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A9337 {ECO:0000313|EMBL:AGR54514.1};
RA Chen W., Chen J., Liang Z., Li J., Chen L.;
RT "Repeated insertion of Tn6022-related transposons into the comM gene of
RT Acinetobacter baumannii GC2 isolates.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AFV47959.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=K51-65 {ECO:0000313|EMBL:AFV47959.1};
RX PubMed=23229482; DOI=10.1128/AAC.01783-12;
RA Saule M., Samuelsen O., Dumpis U., Sundsfjord A., Karlsone A., Balode A.,
RA Miklasevics E., Karah N.;
RT "Dissemination of a Carbapenem-Resistant Acinetobacter baumannii Strain
RT Belonging to International Clone II/Sequence Type 2 and Harboring a Novel
RT AbaR4-Like Resistance Island in Latvia.";
RL Antimicrob. Agents Chemother. 57:1069-1072(2013).
RN [6] {ECO:0000313|EMBL:AEZ06044.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A91 {ECO:0000313|EMBL:AEZ06044.1};
RA Nigro S.J., Kenyon J.J., Hamidian M., Holt K.E., Pickard D., Dougan G.,
RA Hall R.M.;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:APP30398.1, ECO:0000313|Proteomes:UP000072389}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17978 {ECO:0000313|Proteomes:UP000072389}, and ATCC
RC 17978-VU {ECO:0000313|EMBL:APP30398.1};
RX PubMed=25136007; DOI=10.1128/AAC.03074-14;
RA Fernando D.M., Xu W., Loewen P.C., Zhanel G.G., Kumar A.;
RT "Triclosan can select for an AdeIJK-overexpressing mutant of Acinetobacter
RT baumannii ATCC 17978 that displays reduced susceptibility to multiple
RT antibiotics.";
RL Antimicrob. Agents Chemother. 58:6424-6431(2014).
RN [8] {ECO:0000313|EMBL:AKQ28957.1, ECO:0000313|Proteomes:UP000036348}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ab04-mff {ECO:0000313|EMBL:AKQ28957.1,
RC ECO:0000313|Proteomes:UP000036348};
RC PLASMID=pAB04-1 {ECO:0000313|EMBL:AKQ32545.1,
RC ECO:0000313|Proteomes:UP000036348};
RX PubMed=26170289; DOI=10.1073/pnas.1502966112;
RA Weber B.S., Ly P.M., Irwin J.N., Pukatzki S., Feldman M.F.;
RT "A multidrug resistance plasmid contains the molecular switch for type VI
RT secretion in Acinetobacter baumannii.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:9442-9447(2015).
RN [9] {ECO:0000313|Proteomes:UP000036348}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ab04-mff {ECO:0000313|Proteomes:UP000036348};
RC PLASMID=pAB04-1 {ECO:0000313|Proteomes:UP000036348};
RA Weber B.S., Ly P.M., Irwin J.N., Pukatzki S., Feldman M.F.;
RT "A multidrug resistance plasmid contains the molecular switch for type VI
RT secretion in Acinetobacter baumannii.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:ALU33477.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A068 {ECO:0000313|EMBL:ALU33477.1};
RC PLASMID=unnamed {ECO:0000313|EMBL:ALU33477.1};
RA Karah N., Dwibedi C.K., Sjostrom K., Edquist P., Johansson A.,
RA Nyunt Wai S., Uhlin B.E.;
RT "Novel Aminoglycoside Resistance Transposons and Transposon-Derived
RT Circular Forms Detected in Carbapenem-Resistant Acinetobacter baumannii
RT Clinical Isolates.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:ALG88329.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=D4 {ECO:0000313|EMBL:ALG88329.1};
RC PLASMID=pD4 {ECO:0000313|EMBL:ALG88329.1};
RA Hamidian M., Holt K.E., Pickard D., Hall R.M.;
RT "Conjugative plasmids carrying the sulphonamide resistance gene sul2.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:KQD50744.1, ECO:0000313|Proteomes:UP000051023}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ABBL067b {ECO:0000313|EMBL:KQD50744.1,
RC ECO:0000313|Proteomes:UP000051023};
RA Ozer E.A., Fitzpatrick M.A., Hauser A.R.;
RT "The utility of whole genome sequencing in characterizing Acinetobacter
RT epidemiology and analyzing hospital outbreaks.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|EMBL:APP30398.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 17978-VU {ECO:0000313|EMBL:APP30398.1};
RA Singh M.K., Fernando D.M., Kumar A.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:AML68795.1, ECO:0000313|Proteomes:UP000070545}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XH859 {ECO:0000313|EMBL:AML68795.1,
RC ECO:0000313|Proteomes:UP000070545};
RA Feng Y., Hua X., Yu Y.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
RN [15] {ECO:0000313|EMBL:OIG72672.1, ECO:0000313|Proteomes:UP000179937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XH647 {ECO:0000313|EMBL:OIG72672.1,
RC ECO:0000313|Proteomes:UP000179937};
RA Hua X., Yu Y.;
RT "The evolution of Acinetobacter baumannii in vivo.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [16] {ECO:0000313|EMBL:APP30398.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 17978-VU {ECO:0000313|EMBL:APP30398.1};
RA Singh M., Fernando D., Kumar A.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [17] {ECO:0000313|EMBL:OWK65020.1, ECO:0000313|Proteomes:UP000197394}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AB360 {ECO:0000313|EMBL:OWK65020.1,
RC ECO:0000313|Proteomes:UP000197394};
RA Wareham D.W., Bean D.C.;
RT "Draft genome sequence of MDR A. baumannii AB360.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN [18] {ECO:0000313|EMBL:OTT16585.1, ECO:0000313|Proteomes:UP000194553}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARLG1317 {ECO:0000313|EMBL:OTT16585.1,
RC ECO:0000313|Proteomes:UP000194553};
RA Kreiswirth B., Manca C., Chen L., Evans S., Fowler V., Patel R.,
RA Chambers H., Bonomo R., Paul V., Sankar J., Gaind R., Ray P., Gautam V.,
RA Biswal M., Datta S., Walia K., Adams M., Nelson K., Sutton G., Fouts D.,
RA Hujer K., Hujer A.;
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN [19] {ECO:0000313|EMBL:AVI34594.1, ECO:0000313|Proteomes:UP000257523}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR_0070 {ECO:0000313|EMBL:AVI34594.1,
RC ECO:0000313|Proteomes:UP000257523};
RA Benahmed F.H., Lutgring J.D., Yoo B., Machado M., Brown A., McAllister G.,
RA Perry A., Halpin A.L., Vavikolanu K., Ott S., Zhao X., Tallon L.,
RA Sadzewicz L., Aluvathingal J., Nadendla S., Voskania-kordi A., Simonyan V.,
RA Patel J., Shawar R.M.;
RT "FDA/CDC Antimicrobial Resistant Isolate Bank Genome Sequencing.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN [20] {ECO:0000313|EMBL:SST30056.1, ECO:0000313|Proteomes:UP000252694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4300STDY7045823 {ECO:0000313|EMBL:SST30056.1,
RC ECO:0000313|Proteomes:UP000252694};
RG Pathogen Informatics;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [21] {ECO:0000313|EMBL:AYY87521.1, ECO:0000313|Proteomes:UP000273577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSN15313 {ECO:0000313|EMBL:AYY87521.1,
RC ECO:0000313|Proteomes:UP000273577};
RA Sorenson N.M., Snesrud E., Xavier D.E., Cacci L.C., Oeleman W.,
RA Iavarone A.T., Mc Gann P., Riley L.W., Moreira B.M.;
RT "A novel plasmid carries a functional mcr-4.3 gene in a colistin-resistant
RT Acinetobacter baumannii clinical strain.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [22] {ECO:0000313|EMBL:QBF37636.1, ECO:0000313|Proteomes:UP000270202}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VB31459 {ECO:0000313|EMBL:QBF37636.1,
RC ECO:0000313|Proteomes:UP000270202};
RC PLASMID=unnamed1 {ECO:0000313|EMBL:QBF37636.1,
RC ECO:0000313|Proteomes:UP000270202};
RA Veeraraghavan B., Vijayakumar S., Neeravi A., Venkatesan M.;
RT "Carbapenem resistant Acinetobacter baumannii_VB31459_hybrid assembly.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [23] {ECO:0000313|EMBL:QCT16708.1, ECO:0000313|Proteomes:UP000300722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB364 {ECO:0000313|EMBL:QCT16708.1,
RC ECO:0000313|Proteomes:UP000300722};
RA Huang W., Wang G., Yin C., Chen D., Dhand A., Chanza M., Dimitrova N.,
RA Fallon J.T.;
RT "Optimizing a Whole-Genome Sequencing Data Processing Pipeline for
RT Precision Surveillance of Healthcare-Associated Infections.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [24] {ECO:0000313|EMBL:TPU60079.1, ECO:0000313|Proteomes:UP000315888}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSN14237 {ECO:0000313|EMBL:TPU60079.1,
RC ECO:0000313|Proteomes:UP000315888};
RA Mcgann P., Snesrud E., Galac M.R.;
RT "A Diverse Panel of Clinical Acinetobacter baumannii for Research Use.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN [25] {ECO:0000313|EMBL:MQZ70700.1, ECO:0000313|Proteomes:UP000420346}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AMA26 {ECO:0000313|EMBL:MQZ70700.1,
RC ECO:0000313|Proteomes:UP000420346};
RA Maria R.S., Adams M.D.;
RT "Distinct mechanisms of dissemination of NDM-1 metallo-beta-betalactamase
RT in Acinetobacter species spp. in Argentina.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN [26] {ECO:0000313|EMBL:MQR51623.1, ECO:0000313|Proteomes:UP000461234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ABS103 {ECO:0000313|EMBL:MQR51623.1,
RC ECO:0000313|Proteomes:UP000461234};
RA Douraghi M., Aris P., Kenyon J., Hamidian M.;
RT "Genetic environment of the oxa23 gene and comparative analysis of
RT carbapenem resistant Acinetobacter baumannii isolates belonging to global
RT clone 1, lineage 2 recovered in a burns hospital outbreak in 2012-2013.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [27] {ECO:0000313|EMBL:MVM92360.1, ECO:0000313|Proteomes:UP000439424}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ac576 {ECO:0000313|EMBL:MVM92360.1,
RC ECO:0000313|Proteomes:UP000439424};
RA Fedrigo N.H., Cerdeira L., Fuga B., Marini P.V.B., Shinohara D.R.,
RA Carrara-Marroni F.E., Lincopan N., Tognim M.C.B.;
RT "Multidrug-resistant Acinetobacter baumannii moving toward extensively
RT drug-resistant over fifteen years in South of Brazil.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN [28] {ECO:0000313|EMBL:NDW43308.1, ECO:0000313|Proteomes:UP000470018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SP816 {ECO:0000313|EMBL:NDW43308.1,
RC ECO:0000313|Proteomes:UP000470018};
RA Veeraraghavan B., Mathur P., Vijayakumar S., Vasudevan K., Lincy M.,
RA Kirubananthan A.;
RT "Whole genome shot-gun sequencing of clinical Carbapenem resistant A.
RT baumannii.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [29] {ECO:0000313|EMBL:QJH23874.1, ECO:0000313|Proteomes:UP000502990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VB82 {ECO:0000313|EMBL:QJH23874.1,
RC ECO:0000313|Proteomes:UP000502990};
RC PLASMID=pVB82_1 {ECO:0000313|EMBL:QJH23874.1}, and pvb82_1
RC {ECO:0000313|Proteomes:UP000502990};
RA Veeraraghavan B., Vijayakumar S., Amala A., Francis L., Kirubananthan A.;
RT "Complete genome of Carbapenem Resistant Acinetobacter baumannii.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [30] {ECO:0000313|Proteomes:UP000503033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PM193665 {ECO:0000313|Proteomes:UP000503033};
RC PLASMID=ppm193665_1 {ECO:0000313|Proteomes:UP000503033};
RA Veeraraghavan B., Vijayakumar S., Amala A., francis L., Kirubananthan A.;
RT "Complete genome sequencing for A.baumanii.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [31] {ECO:0000313|EMBL:QJG84996.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PM193665 {ECO:0000313|EMBL:QJG84996.1};
RC PLASMID=pPM193665_1 {ECO:0000313|EMBL:QJG86150.1};
RA Veeraraghavan B., Vijayakumar S., Amala A., Francis L., Kirubananthan A.;
RT "Complete genome sequencing for A.baumanii.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [32] {ECO:0000313|EMBL:MBP4961777.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E314 {ECO:0000313|EMBL:MBP4961777.1};
RA Frenk S., Rakovitsky N.;
RT "Epidemiology and genetic characterization of 247 CRAB isolated from
RT infections.";
RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
RN [33] {ECO:0000313|EMBL:EHU2486398.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MRSN7100 {ECO:0000313|EMBL:EHU2486398.1};
RA Mcgann P.T.;
RL Submitted (JUL-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the condensation of para-aminobenzoate (pABA) with
CC 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-
CC dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
CC {ECO:0000256|RuleBase:RU361205}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate =
CC 7,8-dihydropteroate + diphosphate; Xref=Rhea:RHEA:19949,
CC ChEBI:CHEBI:17836, ChEBI:CHEBI:17839, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:72950; EC=2.5.1.15;
CC Evidence={ECO:0000256|ARBA:ARBA00000012};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946,
CC ECO:0000256|RuleBase:RU361205};
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-
CC dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-
CC dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.
CC {ECO:0000256|ARBA:ARBA00004763, ECO:0000256|RuleBase:RU361205}.
CC -!- SIMILARITY: Belongs to the DHPS family.
CC {ECO:0000256|RuleBase:RU361205}.
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DR EMBL; AY823412; AAW84261.1; -; Genomic_DNA.
DR EMBL; JN968483; AEZ06044.1; -; Genomic_DNA.
DR EMBL; JX481978; AFV47959.1; -; Genomic_DNA.
DR EMBL; JX844630; AGR54514.1; -; Genomic_DNA.
DR EMBL; CP012006; AKQ28957.1; -; Genomic_DNA.
DR EMBL; CP012007; AKQ32545.1; -; Genomic_DNA.
DR EMBL; CP012007; AKQ32584.1; -; Genomic_DNA.
DR EMBL; KT779035; ALG88329.1; -; Genomic_DNA.
DR EMBL; KT317085; ALU33477.1; -; Genomic_DNA.
DR EMBL; CP014539; AML68795.1; -; Genomic_DNA.
DR EMBL; CP018664; APP30398.1; -; Genomic_DNA.
DR EMBL; CP027178; AVI34594.1; -; Genomic_DNA.
DR EMBL; CP033869; AYY87521.1; -; Genomic_DNA.
DR EMBL; FN293019; CAX63188.1; -; Genomic_DNA.
DR EMBL; AAYNHF020000030; EHU2486398.1; -; Genomic_DNA.
DR EMBL; AAYNHF020000047; EHU2486781.1; -; Genomic_DNA.
DR EMBL; LLFO01000176; KQD50744.1; -; Genomic_DNA.
DR EMBL; JAEHMK010000059; MBP4961777.1; -; Genomic_DNA.
DR EMBL; WIOC01000050; MQR51623.1; -; Genomic_DNA.
DR EMBL; VYTH01000068; MQZ70700.1; -; Genomic_DNA.
DR EMBL; WPIP01000090; MVM92360.1; -; Genomic_DNA.
DR EMBL; JAAGTY010000065; NDW43308.1; -; Genomic_DNA.
DR EMBL; LYKI01000022; OIG72672.1; -; Genomic_DNA.
DR EMBL; NGHO01000097; OTT16585.1; -; Genomic_DNA.
DR EMBL; NGKM01000030; OWK65020.1; -; Genomic_DNA.
DR EMBL; CP035931; QBF37636.1; -; Genomic_DNA.
DR EMBL; CP035931; QBF37674.1; -; Genomic_DNA.
DR EMBL; CP040425; QCT16708.1; -; Genomic_DNA.
DR EMBL; CP050415; QJG84996.1; -; Genomic_DNA.
DR EMBL; CP050416; QJG86150.1; -; Genomic_DNA.
DR EMBL; CP050416; QJG86260.1; -; Genomic_DNA.
DR EMBL; CP050386; QJH23874.1; -; Genomic_DNA.
DR EMBL; CP050386; QJH23905.1; -; Genomic_DNA.
DR EMBL; UFMQ01000023; SST30056.1; -; Genomic_DNA.
DR EMBL; VHGY01000083; TPU60079.1; -; Genomic_DNA.
DR RefSeq; WP_001043260.1; NZ_WYAS01000054.1.
DR STRING; 1096995.BJAB07104_00246; -.
DR GeneID; 84568452; -.
DR PATRIC; fig|470.1294.peg.721; -.
DR eggNOG; COG0294; Bacteria.
DR UniPathway; UPA00077; UER00156.
DR Proteomes; UP000036348; Plasmid pAB04-1.
DR Proteomes; UP000051023; Unassembled WGS sequence.
DR Proteomes; UP000070545; Chromosome.
DR Proteomes; UP000072389; Chromosome.
DR Proteomes; UP000179937; Unassembled WGS sequence.
DR Proteomes; UP000194553; Unassembled WGS sequence.
DR Proteomes; UP000197394; Unassembled WGS sequence.
DR Proteomes; UP000252694; Unassembled WGS sequence.
DR Proteomes; UP000257523; Chromosome.
DR Proteomes; UP000270202; Plasmid unnamed1.
DR Proteomes; UP000273577; Chromosome.
DR Proteomes; UP000300722; Chromosome.
DR Proteomes; UP000315888; Unassembled WGS sequence.
DR Proteomes; UP000420346; Unassembled WGS sequence.
DR Proteomes; UP000439424; Unassembled WGS sequence.
DR Proteomes; UP000461234; Unassembled WGS sequence.
DR Proteomes; UP000470018; Unassembled WGS sequence.
DR Proteomes; UP000502990; Plasmid pvb82_1.
DR Proteomes; UP000503033; Plasmid ppm193665_1.
DR Proteomes; UP000673677; Unassembled WGS sequence.
DR Proteomes; UP000737470; Unassembled WGS sequence.
DR GO; GO:0004156; F:dihydropteroate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00739; DHPS; 1.
DR Gene3D; 3.20.20.20; Dihydropteroate synthase-like; 1.
DR InterPro; IPR045031; DHP_synth-like.
DR InterPro; IPR006390; DHP_synth_dom.
DR InterPro; IPR011005; Dihydropteroate_synth-like_sf.
DR InterPro; IPR000489; Pterin-binding_dom.
DR NCBIfam; TIGR01496; DHPS; 1.
DR PANTHER; PTHR20941; FOLATE SYNTHESIS PROTEINS; 1.
DR PANTHER; PTHR20941:SF1; FOLIC ACID SYNTHESIS PROTEIN FOL1; 1.
DR Pfam; PF00809; Pterin_bind; 1.
DR SUPFAM; SSF51717; Dihydropteroate synthetase-like; 1.
DR PROSITE; PS00792; DHPS_1; 1.
DR PROSITE; PS00793; DHPS_2; 1.
DR PROSITE; PS50972; PTERIN_BINDING; 1.
PE 3: Inferred from homology;
KW Folate biosynthesis {ECO:0000256|ARBA:ARBA00022909,
KW ECO:0000256|RuleBase:RU361205};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU361205};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361205}; Plasmid {ECO:0000313|EMBL:AKQ32545.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361205}.
FT DOMAIN 5..259
FT /note="Pterin-binding"
FT /evidence="ECO:0000259|PROSITE:PS50972"
SQ SEQUENCE 271 AA; 28470 MW; 4B00E71A3F7970FB CRC64;
MNKSLIIFGI VNITSDSFSD GGRYLAPDAA IAQARKLMAE GADVIDLGPA SSNPDAAPVS
SDTEIARIAP VLDALKADGI PVSLDSYQPA TQAYALSRGV AYLNDIRGFP DAAFYPQLAK
SSAKLVVMHS VQDGQADRRE APAGDIMDHI AAFFDARIAA LTGAGIKRNR LVLDPGMGFF
LGAAPETSLS VLARFDELRL RFDLPVLLSV SRKSFLRALT GRGPGDVGAA TLAAELAAAA
GGADFIRTHE PRPLRDGLAV LAALKETARI R
//
