ID Q5GQR9_BPSYP Unreviewed; 295 AA.
AC Q5GQR9;
DT 01-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2005, sequence version 1.
DT 03-MAY-2023, entry version 69.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN Name=Dam {ECO:0000313|EMBL:CAF34065.1};
GN ORFNames=S-PM2d001 {ECO:0000313|EMBL:CFW42132.1}, S-PM2p001
GN {ECO:0000313|EMBL:CAF34065.1};
OS Synechococcus phage S-PM2.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Kyanoviridae; Nodensvirus; Nodensvirus spm2.
OX NCBI_TaxID=238854 {ECO:0000313|EMBL:CAF34065.1, ECO:0000313|Proteomes:UP000000994};
OH NCBI_TaxID=1129; Synechococcus.
RN [1] {ECO:0000313|EMBL:CAF34065.1, ECO:0000313|Proteomes:UP000000994}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15263091; DOI=10.1073/pnas.0401478101;
RA Millard A., Clokie M.R., Shub D.A., Mann N.H.;
RT "Genetic organization of the psbAD region in phages infecting marine
RT Synechococcus strains.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:11007-11012(2004).
RN [2] {ECO:0000313|EMBL:CAF34065.1, ECO:0000313|Proteomes:UP000000994}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15838046; DOI=10.1128/JB.187.9.3188-3200.2005;
RA Mann N.H., Clokie M.R., Millard A., Cook A., Wilson W.H., Wheatley P.J.,
RA Letarov A., Krisch H.M.;
RT "The genome of S-PM2, a 'photosynthetic' T4-type bacteriophage that infects
RT marine Synechococcus strains.";
RL J. Bacteriol. 187:3188-3200(2005).
RN [3] {ECO:0000313|EMBL:CFW42132.1, ECO:0000313|Proteomes:UP000246186}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=26177354; DOI=10.1371/journal.pone.0132642;
RA Puxty R.J., Perez-Sepulveda B., Rihtman B., Evans D.J., Millard A.D.,
RA Scanlan D.J.;
RT "Spontaneous Deletion of an "ORFanage" Region Facilitates Host Adaptation
RT in a "Photosynthetic" Cyanophage.";
RL PLoS ONE 10:e0132642-e0132642(2015).
RN [4] {ECO:0000313|EMBL:CFW42132.1}
RP NUCLEOTIDE SEQUENCE.
RA Chooi Y.-H.;
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; AJ630128; CAF34065.1; -; Genomic_DNA.
DR EMBL; LN828717; CFW42132.1; -; Genomic_DNA.
DR RefSeq; YP_195035.1; NC_006820.1.
DR REBASE; 20633; M.SspSPM2ORF1P.
DR GeneID; 3260457; -.
DR KEGG; vg:3260457; -.
DR OrthoDB; 8399at10239; -.
DR Proteomes; UP000000994; Genome.
DR Proteomes; UP000246186; Genome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.10.1020.10; Adenine-specific Methyltransferase, Domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR023095; Ade_MeTrfase_dom_2.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR012263; M_m6A_EcoRV.
DR InterPro; IPR012327; MeTrfase_D12.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR30481; DNA ADENINE METHYLASE; 1.
DR Pfam; PF02086; MethyltransfD12; 1.
DR PIRSF; PIRSF000398; M_m6A_EcoRV; 1.
DR PRINTS; PR00505; D12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CAF34065.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000246186};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 295 AA; 34952 MW; 2D81C6254FF14669 CRC64;
MKTPIRYAGG KSKAYKIITS HLPSTERIVS PFIGGGSLES RWSSELGIEV LGFDIFCALV
NFWDVLLKTP DELADKLQTL TPDKQEYARV KEILLCWRYT QDMLKDWHTD YYKRNPIDLS
KIEAAAYYYY NHNLSYGPMY MGWMSKIYEN QKKWDKMVKN IRDYKNPNLH VAEQTFDNVI
PEYSNDFLYL DPPYYLKKDS DNKMLKGMYP NCNIDVHHTG FDHEKLRDLL HNHKGKFILS
YNNCETIREY YKDFDLYYPE WHYSYQLGET RIGENRIASG TDNTKESHEI LIVKA
//
