ID Q5H725_TAKRU Unreviewed; 810 AA.
AC Q5H725;
DT 01-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=Toll-like receptor 2 {ECO:0000256|PIRNR:PIRNR037595};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|EMBL:AAW69370.1};
RN [1] {ECO:0000313|EMBL:AAW69370.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15976025; DOI=10.1073/pnas.0502272102;
RA Roach J.C., Glusman G., Rowen L., Kaur A., Purcell M.K., Smith K.D.,
RA Hood L.E., Aderem A.;
RT "The evolution of vertebrate Toll-like receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:9577-9582(2005).
CC -!- FUNCTION: Cooperates with LY96 to mediate the innate immune response to
CC bacterial lipoproteins and other microbial cell wall components.
CC Cooperates with TLR1 or TLR6 to mediate the innate immune response to
CC bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6,
CC leading to NF-kappa-B activation, cytokine secretion and the
CC inflammatory response. {ECO:0000256|PIRNR:PIRNR037595}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR EMBL; AC156432; AAW69370.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5H725; -.
DR SMR; Q5H725; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 597..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 648..801
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 810 AA; 91572 MW; 626743FEC5DB5CF8 CRC64;
MFFTLLFTLS FCEGQGSIVK VDRPSCDRCD HSFFCNCSFA GLTCVPVVTE QALSLDLSFN
NITVVTAEDL RDHRRLAALN LCCNRLAVIH QSAFEPLWNL EDLNLSNNQL TALNHRWFHK
LEALRVLNLL HNPYSCLGSP PAFQRLLNLR RLRFGGPALE ELKRGDLAGI THLEELTVHA
NNLRRYESGA LATIWPLGRV ILSLHGPFLT NDDVASTMLG DVSYPETPMI LRDLNLTWIQ
SVHNLRVAAR RRIRHLSFQN LSLSDMATVE FLVVFDGVPL THISVEGVTL KGVGRWEKAN
KTEHKGIDEI FVRDVEVLDI YKFASLISCG FLLQYPRKVS IINAKVFVMP CFTSHLLKNL
QYLDLSNNLL TDMTLAETLC DGDSPLKDLR VLNISGNALK SLSTTSRLVG KLLRLTHLDV
SRNGYSSMPL GCSWPSSLRY LNMSGTRIAS ISPCLPAALE VLDLSNNDLK DFVLVLPTLR
ELHLSGNKLL RLPPGWFFPN LNTLTIQSNS LSMFGPSELR TYSRLQSLQA GWNKFVCTCD
FVGLFQSGVK VGSVQLTDRE DDYICDAPLR LQGALVARVR LPLVHCHPVQ VVSASCVVAL
LATAALGTLL WHVHAFWYLR MMWAWLKAKH SSRQRRGLDQ RGGAGVEDDF DAFVSYSNRD
AGWVENFLVP ELEQPRADDE AAVRARPMTL CLHKRDFLPG HWILDNIMSA MERSRRTIFV
LSENFIRSDW CRYELDFSHF RLFDGVAGEP AILILLEPLN KDDIPRRFCK LRKLLSSTTY
LEWPHGEEKV GEFWKALRTA LRGEEEDGRN
//
