ID GPDA_EHRRW Reviewed; 327 AA.
AC Q5HAM0; Q5FDD3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 01-MAY-2013, entry version 73.
DE RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(P)+];
DE EC=1.1.1.94;
DE AltName: Full=NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
GN Name=gpsA; OrderedLocusNames=Erum6600, ERWE_CDS_06920;
OS Ehrlichia ruminantium (strain Welgevonden).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Ehrlichia.
OX NCBI_TaxID=254945;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Welgevonden;
RX PubMed=15637156; DOI=10.1073/pnas.0406633102;
RA Collins N.E., Liebenberg J., de Villiers E.P., Brayton K.A., Louw E.,
RA Pretorius A., Faber F.E., van Heerden H., Josemans A., van Kleef M.,
RA Steyn H.C., van Strijp M.F., Zweygarth E., Jongejan F., Maillard J.C.,
RA Berthier D., Botha M., Joubert F., Corton C.H., Thomson N.R.,
RA Allsopp M.T., Allsopp B.A.;
RT "The genome of the heartwater agent Ehrlichia ruminantium contains
RT multiple tandem repeats of actively variable copy number.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:838-843(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Welgevonden;
RX PubMed=16547041; DOI=10.1128/JB.188.7.2533-2542.2006;
RA Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y.,
RA Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J.,
RA Martinez D.;
RT "Comparative genomic analysis of three strains of Ehrlichia
RT ruminantium reveals an active process of genome size plasticity.";
RL J. Bacteriol. 188:2533-2542(2006).
CC -!- CATALYTIC ACTIVITY: sn-glycerol 3-phosphate + NAD(P)(+) =
CC glycerone phosphate + NAD(P)H.
CC -!- PATHWAY: Membrane lipid metabolism; glycerophospholipid
CC metabolism.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the NAD-dependent glycerol-3-phosphate
CC dehydrogenase family.
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DR EMBL; CR767821; CAH58392.1; -; Genomic_DNA.
DR EMBL; CR925678; CAI27186.1; -; Genomic_DNA.
DR RefSeq; YP_180524.1; NC_005295.2.
DR RefSeq; YP_197568.1; NC_006832.1.
DR ProteinModelPortal; Q5HAM0; -.
DR STRING; 254945.Erum6600; -.
DR EnsemblBacteria; CAH58392; CAH58392; Erum6600.
DR EnsemblBacteria; CAI27186; CAI27186; ERWE_CDS_06920.
DR GeneID; 3233347; -.
DR GeneID; 3260866; -.
DR KEGG; eru:Erum6600; -.
DR KEGG; erw:ERWE_CDS_06920; -.
DR PATRIC; 20581250; VBIEhrRum92411_0732.
DR eggNOG; COG0240; -.
DR HOGENOM; HOG000246853; -.
DR KO; K00057; -.
DR OMA; DVIGCEI; -.
DR ProtClustDB; PRK14620; -.
DR BioCyc; ERUM254945:GJ2L-724-MONOMER; -.
DR UniPathway; UPA00940; -.
DR GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
DR GO; GO:0047952; F:glycerol-3-phosphate dehydrogenase [NAD(P)+] activity; IEA:HAMAP.
DR GO; GO:0004367; F:glycerol-3-phosphate dehydrogenase [NAD+] activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0046167; P:glycerol-3-phosphate biosynthetic process; IEA:HAMAP.
DR GO; GO:0046168; P:glycerol-3-phosphate catabolic process; IEA:InterPro.
DR GO; GO:0006650; P:glycerophospholipid metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:HAMAP.
DR Gene3D; 1.10.1040.10; -; 1.
DR Gene3D; 3.40.50.720; -; 1.
DR HAMAP; MF_00394; NAD_Glyc3P_dehydrog; 1; -.
DR InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR InterPro; IPR013328; DH_multihelical.
DR InterPro; IPR006168; G3P_DH_NAD-dep.
DR InterPro; IPR006109; G3P_DH_NAD-dep_C.
DR InterPro; IPR011128; G3P_DH_NAD-dep_N.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR PANTHER; PTHR11728; PTHR11728; 1.
DR Pfam; PF07479; NAD_Gly3P_dh_C; 1.
DR Pfam; PF01210; NAD_Gly3P_dh_N; 1.
DR PIRSF; PIRSF000114; Glycerol-3-P_dh; 1.
DR PRINTS; PR00077; GPDHDRGNASE.
DR SUPFAM; SSF48179; 6DGDH_C_like; 1.
DR PROSITE; PS00957; NAD_G3PDH; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Lipid biosynthesis; Lipid metabolism;
KW NAD; Oxidoreductase; Phospholipid biosynthesis;
KW Phospholipid metabolism.
FT CHAIN 1 327 Glycerol-3-phosphate dehydrogenase
FT [NAD(P)+].
FT /FTId=PRO_0000255311.
FT NP_BIND 7 12 NAD (By similarity).
FT REGION 257 258 Substrate binding (By similarity).
FT ACT_SITE 191 191 Proton acceptor (By similarity).
FT BINDING 108 108 NAD; via amide nitrogen (By similarity).
FT BINDING 108 108 Substrate (By similarity).
FT BINDING 140 140 NAD; via amide nitrogen (By similarity).
FT BINDING 257 257 NAD (By similarity).
FT BINDING 283 283 NAD (By similarity).
SQ SEQUENCE 327 AA; 35712 MW; B81E4778E618B776 CRC64;
MKISILGAGS FGTAIAIALS AHGISVNLWG RDHRNTTHIN TYRKNLKYLP TYHLPDNIYA
TSNIDEVLSD NNTCIILTIP TQQLRTICTQ IQHKQHMCKN TPILICSKGI EITSLKFPSE
IAEEILQYNP IFILSGPSFA KEIAEHLPCS IVLAGDNKEL GESLIEKISN DVLKIIYHQD
IIGVQIGAAL KNIIAIACGI IAGKNLGNNA VATVITKGMN EIKTLYIAKN HSIDLHTLIG
PSCLGDLILT CTTEHSRNMA FGLEIGKGRN INTLIDHNLK LVEGTSTVKP LISLAKKLNV
ELPICISIYN LLHENISLDK AISNILS
//
