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Database: UniProt
Entry: Q5HAM0
LinkDB: Q5HAM0
Original site: Q5HAM0 
ID   GPDA_EHRRW              Reviewed;         327 AA.
AC   Q5HAM0; Q5FDD3;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-SEP-2014, entry version 79.
DE   RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(P)+];
DE            EC=1.1.1.94;
DE   AltName: Full=NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
GN   Name=gpsA; OrderedLocusNames=Erum6600, ERWE_CDS_06920;
OS   Ehrlichia ruminantium (strain Welgevonden).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Ehrlichia.
OX   NCBI_TaxID=254945;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Welgevonden;
RX   PubMed=15637156; DOI=10.1073/pnas.0406633102;
RA   Collins N.E., Liebenberg J., de Villiers E.P., Brayton K.A., Louw E.,
RA   Pretorius A., Faber F.E., van Heerden H., Josemans A., van Kleef M.,
RA   Steyn H.C., van Strijp M.F., Zweygarth E., Jongejan F., Maillard J.C.,
RA   Berthier D., Botha M., Joubert F., Corton C.H., Thomson N.R.,
RA   Allsopp M.T., Allsopp B.A.;
RT   "The genome of the heartwater agent Ehrlichia ruminantium contains
RT   multiple tandem repeats of actively variable copy number.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:838-843(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Welgevonden;
RX   PubMed=16547041; DOI=10.1128/JB.188.7.2533-2542.2006;
RA   Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y.,
RA   Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J.,
RA   Martinez D.;
RT   "Comparative genomic analysis of three strains of Ehrlichia
RT   ruminantium reveals an active process of genome size plasticity.";
RL   J. Bacteriol. 188:2533-2542(2006).
CC   -!- CATALYTIC ACTIVITY: sn-glycerol 3-phosphate + NAD(P)(+) =
CC       glycerone phosphate + NAD(P)H.
CC   -!- PATHWAY: Membrane lipid metabolism; glycerophospholipid
CC       metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the NAD-dependent glycerol-3-phosphate
CC       dehydrogenase family.
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DR   EMBL; CR767821; CAH58392.1; -; Genomic_DNA.
DR   EMBL; CR925678; CAI27186.1; -; Genomic_DNA.
DR   RefSeq; WP_011155340.1; NC_006832.1.
DR   RefSeq; YP_180524.1; NC_005295.2.
DR   RefSeq; YP_197568.1; NC_006832.1.
DR   ProteinModelPortal; Q5HAM0; -.
DR   STRING; 254945.Erum6600; -.
DR   EnsemblBacteria; CAH58392; CAH58392; Erum6600.
DR   EnsemblBacteria; CAI27186; CAI27186; ERWE_CDS_06920.
DR   GeneID; 3233347; -.
DR   GeneID; 3260866; -.
DR   KEGG; eru:Erum6600; -.
DR   KEGG; erw:ERWE_CDS_06920; -.
DR   PATRIC; 20581250; VBIEhrRum92411_0732.
DR   eggNOG; COG0240; -.
DR   HOGENOM; HOG000246853; -.
DR   KO; K00057; -.
DR   OMA; HLLHCGK; -.
DR   OrthoDB; EOG6JDWF4; -.
DR   BioCyc; ERUM254945:GJ2L-724-MONOMER; -.
DR   UniPathway; UPA00940; -.
DR   GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
DR   GO; GO:0047952; F:glycerol-3-phosphate dehydrogenase [NAD(P)+] activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004367; F:glycerol-3-phosphate dehydrogenase [NAD+] activity; IEA:UniProtKB-EC.
DR   GO; GO:0036439; F:glycerol-3-phosphate dehydrogenase [NADP+] activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0046167; P:glycerol-3-phosphate biosynthetic process; IEA:UniProtKB-HAMAP.
DR   GO; GO:0046168; P:glycerol-3-phosphate catabolic process; IEA:InterPro.
DR   GO; GO:0006650; P:glycerophospholipid metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   Gene3D; 3.40.50.720; -; 1.
DR   HAMAP; MF_00394; NAD_Glyc3P_dehydrog; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR006168; G3P_DH_NAD-dep.
DR   InterPro; IPR006109; G3P_DH_NAD-dep_C.
DR   InterPro; IPR011128; G3P_DH_NAD-dep_N.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   PANTHER; PTHR11728; PTHR11728; 1.
DR   Pfam; PF07479; NAD_Gly3P_dh_C; 1.
DR   Pfam; PF01210; NAD_Gly3P_dh_N; 1.
DR   PIRSF; PIRSF000114; Glycerol-3-P_dh; 1.
DR   PRINTS; PR00077; GPDHDRGNASE.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   PROSITE; PS00957; NAD_G3PDH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Lipid biosynthesis; Lipid metabolism;
KW   NAD; Oxidoreductase; Phospholipid biosynthesis;
KW   Phospholipid metabolism.
FT   CHAIN         1    327       Glycerol-3-phosphate dehydrogenase
FT                                [NAD(P)+].
FT                                /FTId=PRO_0000255311.
FT   NP_BIND       7     12       NAD (By similarity).
FT   REGION      257    258       Substrate binding (By similarity).
FT   ACT_SITE    191    191       Proton acceptor (By similarity).
FT   BINDING     108    108       NAD; via amide nitrogen (By similarity).
FT   BINDING     108    108       Substrate (By similarity).
FT   BINDING     140    140       NAD; via amide nitrogen (By similarity).
FT   BINDING     257    257       NAD (By similarity).
FT   BINDING     283    283       NAD (By similarity).
SQ   SEQUENCE   327 AA;  35712 MW;  B81E4778E618B776 CRC64;
     MKISILGAGS FGTAIAIALS AHGISVNLWG RDHRNTTHIN TYRKNLKYLP TYHLPDNIYA
     TSNIDEVLSD NNTCIILTIP TQQLRTICTQ IQHKQHMCKN TPILICSKGI EITSLKFPSE
     IAEEILQYNP IFILSGPSFA KEIAEHLPCS IVLAGDNKEL GESLIEKISN DVLKIIYHQD
     IIGVQIGAAL KNIIAIACGI IAGKNLGNNA VATVITKGMN EIKTLYIAKN HSIDLHTLIG
     PSCLGDLILT CTTEHSRNMA FGLEIGKGRN INTLIDHNLK LVEGTSTVKP LISLAKKLNV
     ELPICISIYN LLHENISLDK AISNILS
//
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