ID Y201_STAAC Reviewed; 252 AA.
AC Q5HJF7;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 01-MAY-2013, entry version 73.
DE RecName: Full=Uncharacterized response regulatory protein SACOL0201;
GN OrderedLocusNames=SACOL0201;
OS Staphylococcus aureus (strain COL).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX NCBI_TaxID=93062;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COL;
RX PubMed=15774886; DOI=10.1128/JB.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T.,
RA Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J.,
RA Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S.,
RA Haft D.H., Vamathevan J.J., Khouri H., Utterback T.R., Lee C.,
RA Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H.,
RA Hance I.R., Nelson K.E., Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete
RT genome analysis of an early methicillin-resistant Staphylococcus
RT aureus strain and a biofilm-producing methicillin-resistant
RT Staphylococcus epidermidis strain.";
RL J. Bacteriol. 187:2426-2438(2005).
RN [2]
RP INDUCTION DURING ANAEROBIC GROWTH.
RX PubMed=17384184; DOI=10.1128/JB.00081-07;
RA Fuchs S., Pane-Farre J., Kohler C., Hecker M., Engelmann S.;
RT "Anaerobic gene expression in Staphylococcus aureus.";
RL J. Bacteriol. 189:4275-4289(2007).
CC -!- FUNCTION: Probable member of the two-component regulatory system
CC SACOL0202/SACOL0201.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC -!- INDUCTION: Up-regulated during anaerobic growth.
CC -!- PTM: Phosphorylated by SACOL0202 (Potential).
CC -!- SIMILARITY: Contains 1 HTH araC/xylS-type DNA-binding domain.
CC -!- SIMILARITY: Contains 1 response regulatory domain.
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DR EMBL; CP000046; AAW37497.1; -; Genomic_DNA.
DR RefSeq; YP_185100.1; NC_002951.2.
DR ProteinModelPortal; Q5HJF7; -.
DR SMR; Q5HJF7; 2-241.
DR STRING; 93062.SACOL0201; -.
DR EnsemblBacteria; AAW37497; AAW37497; SACOL0201.
DR GeneID; 3236771; -.
DR KEGG; sac:SACOL0201; -.
DR PATRIC; 19526668; VBIStaAur112458_0200.
DR eggNOG; COG4753; -.
DR HOGENOM; HOG000059795; -.
DR KO; K07720; -.
DR OMA; ICEYVIN; -.
DR ProtClustDB; CLSK884492; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:GOC.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.60; -; 2.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR009057; Homeodomain-like.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR Pfam; PF12833; HTH_18; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; CheY_like; 1.
DR SUPFAM; SSF46689; Homeodomain_like; 2.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; FALSE_NEG.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
KW Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1 252 Uncharacterized response regulatory
FT protein SACOL0201.
FT /FTId=PRO_0000299109.
FT DOMAIN 3 118 Response regulatory.
FT DOMAIN 153 250 HTH araC/xylS-type.
FT DNA_BIND 170 191 H-T-H motif (By similarity).
FT DNA_BIND 217 240 H-T-H motif (By similarity).
FT MOD_RES 55 55 4-aspartylphosphate (By similarity).
SQ SEQUENCE 252 AA; 29599 MW; F42C8E41A0CE4082 CRC64;
MFKVVICDDE RIIREGLKQI IPWGDYHFNT IYTAKDGVEA LSLIQQHQPE LVITDIRMPR
KNGVDLLNDI AHLDCNVIIL SSYDDFEYMK AGIQHHVLDY LLKPVDHAQL EVILGRLVRT
LLEQQSQNGR SLASCHDAFQ PLLKVEYDDY YVNQIVDQIK QSYQTKVTVS DLIQHIDVSE
SYAMRTFKDH VGITIVDYLN RYRILQSLQL LDRHYKHYEI ADKVGFSEYK MFSYHFKKYL
QMSPSDYCKQ AK
//
