ID Q5HM48_STAEQ Unreviewed; 653 AA.
AC Q5HM48;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Sialic acid synthase {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=SERP1781 {ECO:0000313|EMBL:AAW55149.1};
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279 {ECO:0000313|EMBL:AAW55149.1, ECO:0000313|Proteomes:UP000000531};
RN [1] {ECO:0000313|EMBL:AAW55149.1, ECO:0000313|Proteomes:UP000000531}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A {ECO:0000313|Proteomes:UP000000531};
RX PubMed=15774886; DOI=10.1128/JB.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., Deboy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L., Beanan M., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J., Khouri H., Utterback T., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K., Hance I.R., Nelson K.E., Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the IucA/IucC family.
CC {ECO:0000256|ARBA:ARBA00007832}.
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DR EMBL; CP000029; AAW55149.1; -; Genomic_DNA.
DR RefSeq; WP_002456996.1; NC_002976.3.
DR AlphaFoldDB; Q5HM48; -.
DR STRING; 176279.SERP1781; -.
DR GeneID; 50018123; -.
DR KEGG; ser:SERP1781; -.
DR eggNOG; COG4264; Bacteria.
DR HOGENOM; CLU_018524_3_1_9; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0016881; F:acid-amino acid ligase activity; IEA:UniProt.
DR GO; GO:0019290; P:siderophore biosynthetic process; IEA:InterPro.
DR Gene3D; 1.10.510.40; -; 1.
DR InterPro; IPR007310; Aerobactin_biosyn_IucA/IucC_N.
DR InterPro; IPR022770; IucA/IucC-like_C.
DR InterPro; IPR037455; LucA/IucC-like.
DR PANTHER; PTHR34384; L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE; 1.
DR PANTHER; PTHR34384:SF6; STAPHYLOFERRIN B SYNTHASE; 1.
DR Pfam; PF06276; FhuF; 1.
DR Pfam; PF04183; IucA_IucC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000531}.
FT DOMAIN 194..437
FT /note="Aerobactin siderophore biosynthesis IucA/IucC N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF04183"
FT DOMAIN 470..637
FT /note="Aerobactin siderophore biosynthesis IucA/IucC-like
FT C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06276"
SQ SEQUENCE 653 AA; 76380 MW; EB3A7B149F73E080 CRC64;
MNFNQFINKQ NIIMTEDEHN VYDFLKHHNP NWSSNYIDHL LDGRDKVSQR LITSLHRENL
VKSRDHSRIL NRHQFAGYGV NVIAILEIYF PTSNIYLYAP ITGMHAFDRI DVEGPFYFKN
LSKEDDFERV LHPNQILDWI LIEDENLNNE ASVQFRNDLN NSAANMTFAL SFQHYTMRNE
RAPLYNLIKN ANDSYLRSEQ SVIEGHPLHP GAKLRKGMNA EENFMYSSEF GNVIHLRAVF
IHKSISRIQS SNVDYNVAVK QMFPDLIKTL EKEFGEDFNL QNYHLMMVHP WQIKHILQSD
YRDELNEKLI LISNHSVPYY AGLSFRTLVP KQPDLSPHIK LSTNVHITGE IRTLSEQTTY
NGPLVTQILR EIMSKDEDFS HYQSTYIDEN AGIHFYNRND NEAIQTDRSE QLGTLFRNNL
YQFISNETVP VIPSSLVATY PYNTEAPICT LIKTYQNTYQ YKNYEEAAKQ WIKDYSKALL
GLVIPLYSKY GISLEAHLQN SVATFNKDGS LNMIYIRDFE GLRIDNEQLN NAGFTTRHFH
EKSRILTNSK TSVFNKMFYS TVQNHLGELV ITIAKYSNSK VLEQEIWQII SQTVEDIFNH
MTHISKQHLN NIKRTIFASE IDYKCVTTMR LEDQAHEYTY IKVHNPLHRK NDL
//
