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Database: UniProt
Entry: Q5HN96
LinkDB: Q5HN96
Original site: Q5HN96 
ID   PRSA_STAEQ              Reviewed;         325 AA.
AC   Q5HN96;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   01-OCT-2014, entry version 67.
DE   RecName: Full=Foldase protein PrsA {ECO:0000255|HAMAP-Rule:MF_01145};
DE            EC=5.2.1.8 {ECO:0000255|HAMAP-Rule:MF_01145};
DE   Flags: Precursor;
GN   Name=prsA {ECO:0000255|HAMAP-Rule:MF_01145};
GN   OrderedLocusNames=SERP1376;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/JB.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T.,
RA   Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J.,
RA   Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S.,
RA   Haft D.H., Vamathevan J.J., Khouri H., Utterback T.R., Lee C.,
RA   Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H.,
RA   Hance I.R., Nelson K.E., Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete
RT   genome analysis of an early methicillin-resistant Staphylococcus
RT   aureus strain and a biofilm-producing methicillin-resistant
RT   Staphylococcus epidermidis strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Plays a major role in protein secretion by helping the
CC       post-translocational extracellular folding of several secreted
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01145}.
CC   -!- CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline
CC       (omega=0). {ECO:0000255|HAMAP-Rule:MF_01145}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01145}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_01145}.
CC   -!- SIMILARITY: Belongs to the PrsA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01145}.
CC   -!- SIMILARITY: Contains 1 PpiC domain. {ECO:0000255|HAMAP-
CC       Rule:MF_01145}.
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DR   EMBL; CP000029; AAW54761.1; -; Genomic_DNA.
DR   RefSeq; YP_188945.1; NC_002976.3.
DR   ProteinModelPortal; Q5HN96; -.
DR   STRING; 176279.SERP1376; -.
DR   EnsemblBacteria; AAW54761; AAW54761; SERP1376.
DR   GeneID; 3242867; -.
DR   KEGG; ser:SERP1376; -.
DR   PATRIC; 19613619; VBIStaEpi130894_1344.
DR   eggNOG; COG0760; -.
DR   HOGENOM; HOG000014031; -.
DR   KO; K07533; -.
DR   OMA; KKESMDK; -.
DR   OrthoDB; EOG66XBH5; -.
DR   BioCyc; SEPI176279:GJJB-1411-MONOMER; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_01145; Foldase_PrsA; 1.
DR   InterPro; IPR023059; Foldase_PrsA.
DR   InterPro; IPR000297; PPIase_PpiC.
DR   InterPro; IPR027304; Trigger_fact/SurA_dom.
DR   SUPFAM; SSF109998; SSF109998; 1.
DR   PROSITE; PS50198; PPIC_PPIASE_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Isomerase; Lipoprotein; Membrane;
KW   Palmitate; Reference proteome; Rotamase; Signal.
FT   SIGNAL        1     20       {ECO:0000255|HAMAP-Rule:MF_01145}.
FT   CHAIN        21    325       Foldase protein PrsA.
FT                                /FTId=PRO_0000042940.
FT   DOMAIN      139    245       PpiC. {ECO:0000255|HAMAP-Rule:MF_01145}.
FT   LIPID        21     21       N-palmitoyl cysteine. {ECO:0000255|HAMAP-
FT                                Rule:MF_01145}.
FT   LIPID        21     21       S-diacylglycerol cysteine.
FT                                {ECO:0000255|HAMAP-Rule:MF_01145}.
SQ   SEQUENCE   325 AA;  36496 MW;  502B3FB3B799EB80 CRC64;
     MKLMNKIIVP VTASALLLGA CGSNATESKD NTLISSKAGD VKVADVMKKM GKEQIANTSF
     SIVLNKVLAD KYKDKVDTKD IDKDIKKEEK QYGGKDQFES MLKQQGMSLD DYKEQKKLSA
     YQKQLLLDKV NVSDKEIKEN SKKTSHILIK VKSKSSDKEG LSDKKAKEKA EKIQKEVEKN
     PNKFGEIAKK ESMDSSSAKK DGSLGYVIKG QMVDSFEKAL FKLKEGEVSK VVKTDYGYHI
     IKADKETDFN SEKSNIKQKL IEEKVQKKPK LLTDAYKELL KEYKVDYKDR DIKKAIEDSI
     LDPDKIKQQQ QQQSQGGSGL TNSGS
//
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