GenomeNet

Database: UniProt
Entry: Q5HPX5
LinkDB: Q5HPX5
Original site: Q5HPX5 
ID   FMT_STAEQ               Reviewed;         310 AA.
AC   Q5HPX5;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   01-OCT-2014, entry version 68.
DE   RecName: Full=Methionyl-tRNA formyltransferase {ECO:0000255|HAMAP-Rule:MF_00182};
DE            EC=2.1.2.9 {ECO:0000255|HAMAP-Rule:MF_00182};
GN   Name=fmt {ECO:0000255|HAMAP-Rule:MF_00182};
GN   OrderedLocusNames=SERP0782;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/JB.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T.,
RA   Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J.,
RA   Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S.,
RA   Haft D.H., Vamathevan J.J., Khouri H., Utterback T.R., Lee C.,
RA   Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H.,
RA   Hance I.R., Nelson K.E., Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete
RT   genome analysis of an early methicillin-resistant Staphylococcus
RT   aureus strain and a biofilm-producing methicillin-resistant
RT   Staphylococcus epidermidis strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Modifies the free amino group of the aminoacyl moiety of
CC       methionyl-tRNA(fMet). The formyl group appears to play a dual role
CC       in the initiator identity of N-formylmethionyl-tRNA by: (I)
CC       promoting its recognition by IF2 and (II) impairing its binding to
CC       EFTu-GTP. {ECO:0000255|HAMAP-Rule:MF_00182}.
CC   -!- CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + L-methionyl-
CC       tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).
CC       {ECO:0000255|HAMAP-Rule:MF_00182}.
CC   -!- SIMILARITY: Belongs to the Fmt family. {ECO:0000255|HAMAP-
CC       Rule:MF_00182}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000029; AAW54200.1; -; Genomic_DNA.
DR   RefSeq; YP_188365.1; NC_002976.3.
DR   ProteinModelPortal; Q5HPX5; -.
DR   STRING; 176279.SERP0782; -.
DR   EnsemblBacteria; AAW54200; AAW54200; SERP0782.
DR   GeneID; 3241559; -.
DR   KEGG; ser:SERP0782; -.
DR   PATRIC; 19612435; VBIStaEpi130894_0760.
DR   eggNOG; COG0223; -.
DR   HOGENOM; HOG000261177; -.
DR   KO; K00604; -.
DR   OMA; EVNSHAN; -.
DR   OrthoDB; EOG6B09WV; -.
DR   BioCyc; SEPI176279:GJJB-808-MONOMER; -.
DR   GO; GO:0004479; F:methionyl-tRNA formyltransferase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR   Gene3D; 3.10.25.10; -; 1.
DR   Gene3D; 3.40.50.170; -; 1.
DR   HAMAP; MF_00182; Formyl_trans; 1.
DR   InterPro; IPR005794; Fmt.
DR   InterPro; IPR005793; Formyl_trans_C.
DR   InterPro; IPR002376; Formyl_transf_N.
DR   InterPro; IPR011034; Formyl_transferase_C-like.
DR   InterPro; IPR001555; GART_AS.
DR   InterPro; IPR015518; Met_tRNA_Form_TA-like.
DR   PANTHER; PTHR11138; PTHR11138; 1.
DR   Pfam; PF02911; Formyl_trans_C; 1.
DR   Pfam; PF00551; Formyl_trans_N; 1.
DR   SUPFAM; SSF50486; SSF50486; 1.
DR   SUPFAM; SSF53328; SSF53328; 1.
DR   TIGRFAMs; TIGR00460; fmt; 1.
DR   PROSITE; PS00373; GART; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Protein biosynthesis; Reference proteome;
KW   Transferase.
FT   CHAIN         1    310       Methionyl-tRNA formyltransferase.
FT                                /FTId=PRO_0000083052.
FT   REGION      109    112       Tetrahydrofolate (THF) binding.
FT                                {ECO:0000255|HAMAP-Rule:MF_00182}.
SQ   SEQUENCE   310 AA;  34101 MW;  268C680D348F605B CRC64;
     MSKIIFMGTP DFSTKVLEML IAEHEVIAVV TQPDRPVGRK KVMTPPPVKR VATKHQIPVY
     QPEKLKDSQE LDVLLSLESD LIVTAAFGQL LPESLLNAPK LGAINVHASL LPKYRGGAPI
     HQAIIDGEEE TGITIMYMVK KLDAGNIISQ QSIRIEEEDN VGTMHDKLSF LGAELLKKTL
     PSIIDNTNDS IPQDDALATF ASNIRREDER IDWNMSAQAI HNHIRGLSPW PVAYTTMNEK
     NLKLFSAFIV KGKKGNPGTI IEATKHELII ATGSDDAIAL TEIQPAGKKR MKVTDYLSGV
     QESLVGKVLL
//
DBGET integrated database retrieval system