ID Q5IQR6_SHIBO Unreviewed; 939 AA.
AC Q5IQR6;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Intimin {ECO:0000256|ARBA:ARBA00017346};
DE AltName: Full=Attaching and effacing protein {ECO:0000256|ARBA:ARBA00029955};
GN Name=eae {ECO:0000313|EMBL:AAU88272.1};
OS Shigella boydii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=621 {ECO:0000313|EMBL:AAU88272.1};
RN [1] {ECO:0000313|EMBL:AAU88272.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=K-1 {ECO:0000313|EMBL:AAU88272.1};
RX PubMed=15629933; DOI=10.1128/JB.187.2.619-628.2005;
RA Hyma K.E., Lacher D.W., Nelson A.M., Bumbaugh A.C., Janda J.M.,
RA Strockbine N.A., Young V.B., Whittam T.S.;
RT "Evolutionary genetics of a new pathogenic Escherichia species: Escherichia
RT albertii and related Shigella boydii strains.";
RL J. Bacteriol. 187:619-628(2005).
RN [2] {ECO:0000313|EMBL:AAU88272.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=K-1 {ECO:0000313|EMBL:AAU88272.1};
RA Hyma K.E., Lacher D.W., Abu-Ali G.S., Nelson A.M., Janda J.M.,
RA Strockbine N.A., Young V.B., Whittam T.S.;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004203}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004203}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the intimin/invasin family.
CC {ECO:0000256|ARBA:ARBA00010116}.
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DR EMBL; AY696839; AAU88272.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5IQR6; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd00037; CLECT; 1.
DR Gene3D; 2.60.40.1080; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.40.160.160; Inverse autotransporter, beta-domain; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR003344; Big_1_dom.
DR InterPro; IPR003343; Big_2.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR024519; IAT_beta.
DR InterPro; IPR038177; IAT_beta_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003535; Intimin/invasin_bac.
DR InterPro; IPR013117; Intimin_C.
DR InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR InterPro; IPR018392; LysM_dom.
DR PANTHER; PTHR39576:SF2; ATTACHING AND EFFACING PROTEIN HOMOLOG-RELATED; 1.
DR PANTHER; PTHR39576; ATTACHING AND EFFACING PROTEIN HOMOLOG-RELATED-RELATED; 1.
DR Pfam; PF02369; Big_1; 2.
DR Pfam; PF02368; Big_2; 1.
DR Pfam; PF11924; IAT_beta; 1.
DR Pfam; PF07979; Intimin_C; 1.
DR Pfam; PF01476; LysM; 1.
DR PRINTS; PR01369; INTIMIN.
DR SMART; SM00634; BID_1; 2.
DR SMART; SM00635; BID_2; 1.
DR SMART; SM00257; LysM; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49373; Invasin/intimin cell-adhesion fragments; 3.
DR PROSITE; PS51127; BIG1; 2.
DR PROSITE; PS51782; LYSM; 1.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|ARBA:ARBA00023237};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 63..112
FT /note="LysM"
FT /evidence="ECO:0000259|PROSITE:PS51782"
FT DOMAIN 560..653
FT /note="Big-1"
FT /evidence="ECO:0000259|PROSITE:PS51127"
FT DOMAIN 660..751
FT /note="Big-1"
FT /evidence="ECO:0000259|PROSITE:PS51127"
SQ SEQUENCE 939 AA; 102274 MW; 2EBEF5FA49EDE218 CRC64;
MITHGCYTRT RHKHKLKKTF VMLSAGLGLF FYVNQNSFAN GENYFKLSSD SKLLTQNAAQ
NRLFYTLKTG ETVADLSKSQ NINLSTIWSL NKHLYSSESE MMKAAPGQQI ILPLKKLPVE
YSALPHLGSA PVVAAGGVAG HTNKMAKMSP DMTKSNMTDD KALNYAAQQA ASLGSQLQSR
SLNGDYAKDA ALGMAGNQAS SQLQAWLQHY GTAEVNLQSG NNFDGSSLDF LLPFYDTEEM
LAFGQVGARY IDSRFTANLG AGQRFFLSEN MLGYNIFIDQ DFSGDNTRLG IGGEYWRDYF
KSSVNGYFRM SGWHESYNKK DYDERPVNGF DIRFNGYLPS YPALGAKLMY EQYYGDNVAL
FNADKLQSNP GAATVGVNYT PVPLVTMGVD YRHGTGNEND LLYSMQFRYQ FDKPWSQQIE
PQYVNELRTL SGSRYDLVQR NNNIILEYKK QDILSLSIPH DINGTEHSTQ KIQLSVKSKY
GLDRIVWDDS ALRSQGGQIQ HSGSQSAQDY QAILPAYVQG GSNIYKVTAR AYDRNGNSSN
NVQLTITVLS NGQVVGQVGV TDFTADKTSA KADNADTITY TATVKKNGVA QANIPVSFDI
VSGDATLSAR SATTNSSGKA TVTLKSSKPG QVVVSAKTAE MTSALNANAV IFVDQNKASI
TEIKANKTTA VANGKDAVTY TVKVMKNGQP VSNQEVAFTT TFGNLSNSAG KTDTDGYAKV
ILTSTTPGKS LVSARVRDVA VDVKAPEVEF FTSLAIDDSN VEIVGTGIKG KLPTVWLQYG
QVKLKASGGD GKYTWRSANP KIASVDSTGQ VTLRDKGTTT ITVVSGDNQT ATYIIATPNS
LIVPNIKNRM TYNDAVSSCQ SLGGRLPSSQ SELANVFNTW GAANKYEHYN ASTTIISWVK
QTEEDMKKGV ADTYDLVNQN PLNGIVNTKK PNAYATCVK
//
