ID ACM5_SAIBB Reviewed; 532 AA.
AC Q5IS98;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 09-JAN-2013, entry version 41.
DE RecName: Full=Muscarinic acetylcholine receptor M5;
GN Name=CHRM5;
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Platyrrhini; Cebidae; Saimiriinae; Saimiri.
OX NCBI_TaxID=39432;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15620360; DOI=10.1016/j.cell.2004.11.040;
RA Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L.,
RA Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.;
RT "Accelerated evolution of nervous system genes in the origin of Homo
RT sapiens.";
RL Cell 119:1027-1040(2004).
CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various
CC cellular responses, including inhibition of adenylate cyclase,
CC breakdown of phosphoinositides and modulation of potassium
CC channels through the action of G proteins. Primary transducing
CC effect is Pi turnover.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC Cell junction, synapse, postsynaptic cell membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.
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DR EMBL; AY665230; AAV74268.1; -; mRNA.
DR ProteinModelPortal; Q5IS98; -.
DR HOVERGEN; HBG105720; -.
DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016907; F:G-protein coupled acetylcholine receptor activity; IEA:InterPro.
DR GO; GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; IEA:GOC.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000502; Musac_M5_rcpt.
DR InterPro; IPR000995; Musac_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00243; MUSCARINICR.
DR PRINTS; PR00542; MUSCRINICM5R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; G-protein coupled receptor;
KW Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane;
KW Receptor; Synapse; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1 532 Muscarinic acetylcholine receptor M5.
FT /FTId=PRO_0000069047.
FT TOPO_DOM 1 29 Extracellular (By similarity).
FT TRANSMEM 30 53 Helical; Name=1; (By similarity).
FT TOPO_DOM 54 66 Cytoplasmic (By similarity).
FT TRANSMEM 67 87 Helical; Name=2; (By similarity).
FT TOPO_DOM 88 104 Extracellular (By similarity).
FT TRANSMEM 105 126 Helical; Name=3; (By similarity).
FT TOPO_DOM 127 146 Cytoplasmic (By similarity).
FT TRANSMEM 147 169 Helical; Name=4; (By similarity).
FT TOPO_DOM 170 191 Extracellular (By similarity).
FT TRANSMEM 192 214 Helical; Name=5; (By similarity).
FT TOPO_DOM 215 443 Cytoplasmic (By similarity).
FT TRANSMEM 444 464 Helical; Name=6; (By similarity).
FT TOPO_DOM 465 478 Extracellular (By similarity).
FT TRANSMEM 479 498 Helical; Name=7; (By similarity).
FT TOPO_DOM 499 532 Cytoplasmic (By similarity).
FT MOD_RES 501 501 Phosphothreonine (Potential).
FT MOD_RES 505 505 Phosphothreonine (Potential).
FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential).
SQ SEQUENCE 532 AA; 59873 MW; 4B09E40A3940A8F8 CRC64;
MEGDSYGNAT TINGTPVNHQ PLERHRLWEV ITIAAVTAVV SLITIVGNVL VMISFKVNSQ
LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWALGS LACDLWLALD YVASNASVMN
LLVISFDRYF SITRPLTYRA KRTPKRAGIM IGLAWLISFI LWAPAILCWQ YLVGKRTVPP
DECQIQFLSE PTITFGTAIA AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSVSVTKAE
KRKPAHRALF RSCFRCPRPT LVQRERNQAS RSSSHRSTSI TGKPSQATGP STNWAKAEEL
TTCSSYPSSE DEDKPATDPV LQVVYKSQGK ESPGEEFSAE EAEETFVKGQ TDKNDCDSPD
YFLSPAAAHR PKSQQCVAYK FQLVVKADGT QETNNGCHKV KIMPCSFPVA KEPSTKGLSP
NLSHQMTKRK RMVLVKERKA AQTLSAILLA FIITWTPYNI MVLVSTFCDK CVPVALWHLG
YWLCYVNSTV NPICYALCNR TFRKTFKMLL LCQWKKKKVE EKLYWQGNSK LP
//
