ID Q5JHW0_THEKO Unreviewed; 721 AA.
AC Q5JHW0;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=Probable formate dehydrogenase, alpha subunit {ECO:0000313|EMBL:BAD86265.1};
GN OrderedLocusNames=TK2076 {ECO:0000313|EMBL:BAD86265.1};
OS Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS (Pyrococcus kodakaraensis (strain KOD1)).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=69014 {ECO:0000313|EMBL:BAD86265.1, ECO:0000313|Proteomes:UP000000536};
RN [1] {ECO:0000313|EMBL:BAD86265.1, ECO:0000313|Proteomes:UP000000536}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-918 / JCM 12380 / KOD1
RC {ECO:0000313|Proteomes:UP000000536};
RX PubMed=15710748; DOI=10.1101/gr.3003105;
RA Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL Genome Res. 15:352-363(2005).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. {ECO:0000256|ARBA:ARBA00010312}.
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DR EMBL; AP006878; BAD86265.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5JHW0; -.
DR STRING; 69014.TK2076; -.
DR EnsemblBacteria; BAD86265; BAD86265; TK2076.
DR KEGG; tko:TK2076; -.
DR PATRIC; fig|69014.16.peg.2031; -.
DR eggNOG; arCOG01491; Archaea.
DR HOGENOM; CLU_000422_4_0_2; -.
DR InParanoid; Q5JHW0; -.
DR PhylomeDB; Q5JHW0; -.
DR Proteomes; UP000000536; Chromosome.
DR GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0015942; P:formate metabolic process; IEA:InterPro.
DR CDD; cd00508; MopB_CT_Fdh-Nap-like; 1.
DR CDD; cd02753; MopB_Formate-Dh-H; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR041924; Formate_Dh-H_N.
DR InterPro; IPR006478; Formate_DH_asu.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR NCBIfam; TIGR01591; Fdh-alpha; 1.
DR PANTHER; PTHR43598:SF5; DMSO REDUCTASE CHAIN A; 1.
DR PANTHER; PTHR43598; TUNGSTEN-CONTAINING FORMYLMETHANOFURAN DEHYDROGENASE 2 SUBUNIT B; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR PIRSF; PIRSF000144; CbbBc; 2.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000536}.
FT DOMAIN 14..73
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 721 AA; 80097 MW; 335B4A6847A3B63B CRC64;
MMYSAMMEVL RMDEKLVPVV CPYCGVGCRL YIRSSDGHPL GIEYANDIPG ISNENGKLCP
KGNAVLEYVL ARDRLKKPLK AKEQGKFVEI SWSQAIKEVA ERLKEYSKDD PNSMMFFGSA
KTFNEPNYLI QKLARMLGTN NVDHCARLCH ASTVSGLKAV FGAGAMTNTY RDIEEANVIF
IIGHNFAETH PVGFRYVLKA KERGAKVIVA DPRFTRTAWF ADIYLQHYPG TDIALINGLI
HVIIEERLYD EKFVRERCTG FDELAKTVEK FTPGYVEKIT GVPADLIVQA ARTFATGGKG
VITWAMGITQ HTHGHDNVRL LATLSAICGY QGREGCGVSP MRGQNNVQGA CDLGVLPNVF
PGYKAVSDPE GRKFFEEFWG TELSGEVGLT VIEAAHAIEK GKVRAYYVMG ENPVISDANT
NHVIKALHKL EFMVVQDIVP TPTMEFADIV LPAAAMLENE GSLTNTERRV QWSFQAINPP
GEARPDWWIV SEIGKAAGFT GDGPKGFNYS GPEDILREVN ACTPQYRGIT PERLKANLAG
IHWPCPSEDH PGTRVLYKER FLTSDGKAHL AAVEYRGPAE TPDEDYPFLL TTVRYVGHYH
TLTMTGRSRA LVKRWPEPLA EIHPEDAERL GIKTGDWVKI VTRRGEYPIR AKVTRTVKKG
VIAVPWHWGA NVVTNDALDP VAKIPETKAC ACKVVKITEE EARELMKKVP PVIPEIEIVR
G
//
