ID Q5K705_CRYNJ Unreviewed; 646 AA.
AC Q5K705; Q55HG7;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=AMP binding protein, putative {ECO:0000313|EMBL:AAW47120.2};
GN OrderedLocusNames=CNN01570 {ECO:0000313|EMBL:AAW47120.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW47120.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW47120.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017356; AAW47120.2; -; Genomic_DNA.
DR RefSeq; XP_568637.1; XM_568637.1.
DR AlphaFoldDB; Q5K705; -.
DR STRING; 214684.Q5K705; -.
DR PaxDb; 214684-Q5K705; -.
DR EnsemblFungi; AAW47120; AAW47120; CNN01570.
DR GeneID; 3255350; -.
DR KEGG; cne:CNN01570; -.
DR VEuPathDB; FungiDB:CNN01570; -.
DR eggNOG; KOG1176; Eukaryota.
DR HOGENOM; CLU_000022_59_2_1; -.
DR InParanoid; Q5K705; -.
DR OrthoDB; 1404660at2759; -.
DR Proteomes; UP000002149; Chromosome 14.
DR GO; GO:0016405; F:CoA-ligase activity; IBA:GO_Central.
DR GO; GO:0019748; P:secondary metabolic process; IBA:GO_Central.
DR CDD; cd05911; Firefly_Luc_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24096:SF149; 4-COUMARATE--COA LIGASE 1-RELATED; 1.
DR PANTHER; PTHR24096; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..646
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006744897"
FT DOMAIN 116..485
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 535..620
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 646 AA; 71345 MW; 154EE36669C3572A CRC64;
MALILLIPRV ISLSAALPAI SRLLTSTGPC LLRSLIPNRA NVRPFSSIPL PPGYTFYRNH
NDNNPPPPNM TPRPDQIYVS HIPSPQLPRS SVFEFLFPKS KQYNYFPAPA PNPSGAKKAF
IDGLTGNTVT REQVEEQALA LAGGLKKLGV KTGEVACLFG MNSLEWINAL FGCQALGVVT
SPANYAYTPL ELLHQVKDST SQTIFVQPNL FPVLKEALKL DPSCNIPESK IFLLCPKDKK
PADLKHLKCT EDLWDMGKGI DGRAQWEENV ENKTAYLCYS SGTTGKAKGV ETSHHNMTSQ
IQAVRCSFEP MTEKDVVLGI LPCSHIYGLT MNLHHALSTN GTVVILPKFE EKTVLEVIQR
YKVTFSLIVP PMMIALLHSS LVSSYDISCL RGFQSGAAPL SADLIKAFES RFPHIQVTQG
YGLTETTPVS HVMTLDESRH HPGAIGRVIP TYQARLVDAE NGKDVEIGER GELWLKGPSV
MKGYWRNEEA TRNVFEDGWF KTGDIAIVDD RKYFTIVDRV KELIKYKGFQ VPPAELEALL
LGHPNVADVG VIGIYDKSQA TELPRAYIVP KGGLASLSWS DREKLSKEIH DWAAKKVANH
KKLRGGVILI EAIPKSPSGK ILRKDLRLLA IKEQEEGVKA TRGSKL
//
