ID Q5K7Q6_CRYNJ Unreviewed; 1379 AA.
AC Q5K7Q6; Q55I71;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 130.
DE RecName: Full=Guanyl nucleotide exchange factor Sql2 {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=CNM01620 {ECO:0000313|EMBL:AAW46811.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW46811.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW46811.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017353; AAW46811.2; -; Genomic_DNA.
DR RefSeq; XP_568328.1; XM_568328.1.
DR STRING; 214684.Q5K7Q6; -.
DR PaxDb; 214684-Q5K7Q6; -.
DR EnsemblFungi; AAW46811; AAW46811; CNM01620.
DR VEuPathDB; FungiDB:CNM01620; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002116_0_0_1; -.
DR InParanoid; Q5K7Q6; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000002149; Chromosome 13.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 16..95
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 923..1056
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1125..1359
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 100..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 863..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..684
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1069
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1379 AA; 151473 MW; C811C80A21829190 CRC64;
MTDRQSTPTS PISASPKFSH AQAIHDFDPS LLASTSSSNS NLYLSFKAGE IIRVHVRDPT
GWWDGEITSK VAADNDGRTL RRGWFPSNYI REIEWDPTHR RSESSMSVTS PKSPYKGTHS
RHGSVASHQS NASSSSISQI LTSPRTDIAP LPAAFQILIQ PIVQSLSLLD TAIHNNRKSH
IQPSTACVIS AIRAALSQTD CLSKESRTLM SWPVLAKERK VVLVELSRLV GCARTASGMT
ESAGDSSPGG EMEDMEELAK SARGVFQSVK RFLNLAHQCG VQVTLDTQNE GVPMSVSSSS
SSEIASVSAL VNAPAKSRAS PGSNARLQET FQKRVASIGD LRAAKQRSES PPPLPTGSSQ
SSKHAHTRTA SKANTPISAS FSDVSSPISS RPFEHRIQGS MDSVFSHGST ATSEDTHSPW
EDRTSVSTAA VQPSTPCGNS IADIHLRISY AEDTLLSIIA AFIGHIHSHH IHSHPSSHST
LIEMTRETID AVRTLLTAVE TVGRNTCIRS KRPKEIESLR VAKDRLYDVA GRLVESAEIV
ANAPFEEVVE EGYEKEKAGL LGAATGTLRA GTECVRLVRI CVPEDETIHF NDTPKQSAPT
ASGGRQQLTP RINFDNPVME RDRTVGVRGP HTLSSLHRKA TSLDHLQKRF MEDGGMVQGR
FYGALQNESR QEDEEEEEEV IDEKEEDMTA RPSQGVTFPP SPDPSSQEVQ LYPTPRPRRP
SGELLRGFSE TGRRGPRVRS TSLSTSPTPR IGHMGHRSPS KSADLDKFTS GEDLKLGTDA
KPREAGEAKD RWEASGNVTA ASSRLSMFTS VSSLPSLTHT DSSAKSASEN GDQSTPVKNR
KSPHESLRVV IPKGISNQMS ELSLQNPAEE SVSTAGSSTT LKTLTSRPPV LRTQTSPMPV
PVGDISYLIR SPTYSPADIT YNPDGNMVGA SLAVLVEKMT PHDGPVDSSF SATFFYTFRL
FTTPVDLLEA VQERWFISPP EELLLSEKDE AVWREAKVLP IRIRIFNFLR TWLEFHWQPE
VDNVILNDLE KFGREEMAGS LPVMGERLIN LVQRKKDGGE DEKRKRESMN GPTSASSATL
HPPAVSGLPP TPIISKNLHS LLKKSTAASS SSSSSSTHIH ITEFDTLELA RQLTIIVSKM
FRQLEPEELL MTGKKTVPEL KALSTHSNQV TGWVADSILN EGDAKRRAGL LKFFIKLADK
CLLINNFFTM FAVLGGLNSS TILRLKKTWD ALSVKYKILI ERLRGIIEHT KNHAAYRARL
RQAPTPCLPF LGLILTDITF TSDGNPTTRP SNSAPDLMLI NYDKFAKLGK IAIEFRRYQE
PFNFHELEAV QTFLHTVLTE RGSGSIDALY RKSLMLEPRQ GSEKLRSNVE KPNWLMVKI
//
