ID Q5K883_CRYNJ Unreviewed; 277 AA.
AC Q5K883;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein {ECO:0000259|Pfam:PF02826};
GN OrderedLocusNames=CNL06600 {ECO:0000313|EMBL:AAW46666.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW46666.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW46666.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017352; AAW46666.2; -; Genomic_DNA.
DR RefSeq; XP_568183.1; XM_568183.1.
DR AlphaFoldDB; Q5K883; -.
DR STRING; 214684.Q5K883; -.
DR PaxDb; 214684-Q5K883; -.
DR EnsemblFungi; AAW46666; AAW46666; CNL06600.
DR GeneID; 3255038; -.
DR KEGG; cne:CNL06600; -.
DR VEuPathDB; FungiDB:CNL06600; -.
DR eggNOG; KOG0069; Eukaryota.
DR HOGENOM; CLU_019796_1_0_1; -.
DR InParanoid; Q5K883; -.
DR OrthoDB; 1775226at2759; -.
DR Proteomes; UP000002149; Chromosome 12.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030267; F:glyoxylate reductase (NADP+) activity; IBA:GO_Central.
DR GO; GO:0016618; F:hydroxypyruvate reductase activity; IBA:GO_Central.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43333; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43333:SF1; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 44..240
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 277 AA; 30135 MW; 50B3EDC41F6DF3C0 CRC64;
MKAYVDGRKA ASGKADSKAV RLATASGTHV LSIPNYAVAM AIALLHQLPR QIVGARTEQR
WLSEEECDMD GQAYYARKTF HRTAGLLGYG SLGRETARLL KAHGMRIIAA NTSGKATLQD
GYVIPGTGDK DGSIPEAFYS TKDPKSVKEF LNQCDVLVAS LPNTPATQYF LNKEKLEMLP
KGAVLVNVGR GSLIPSDDLL AVLNTPHLFG AALDVTDPEP LPAQHPLWSH PKCIITPHLS
GNTQGEMEIA ADVLLFNVQR MKDGKEVVNE VRWDRGY
//
