ID Q5K9T5_CRYNJ Unreviewed; 608 AA.
AC Q5K9T5;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:AAW46129.1};
GN OrderedLocusNames=CNK00830 {ECO:0000313|EMBL:AAW46129.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW46129.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW46129.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: May be involved in the turnover of nuclear polyadenylated
CC (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}.
CC -!- SUBUNIT: Associated with the spliceosome.
CC {ECO:0000256|ARBA:ARBA00011524}.
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DR EMBL; AE017351; AAW46129.1; -; Genomic_DNA.
DR RefSeq; XP_567646.1; XM_567646.1.
DR AlphaFoldDB; Q5K9T5; -.
DR STRING; 214684.Q5K9T5; -.
DR PaxDb; 214684-Q5K9T5; -.
DR EnsemblFungi; AAW46129; AAW46129; CNK00830.
DR GeneID; 3254407; -.
DR KEGG; cne:CNK00830; -.
DR VEuPathDB; FungiDB:CNK00830; -.
DR eggNOG; KOG2135; Eukaryota.
DR HOGENOM; CLU_017928_0_0_1; -.
DR InParanoid; Q5K9T5; -.
DR OMA; PSAKCAF; -.
DR OrthoDB; 5406435at2759; -.
DR Proteomes; UP000002149; Chromosome 11.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR CDD; cd12257; RRM1_RBM26_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR002483; PWI_dom.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR045137; RBM26/27.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR14398; RNA RECOGNITION RRM/RNP DOMAIN; 1.
DR PANTHER; PTHR14398:SF0; ZINC FINGER PROTEIN SWM; 1.
DR Pfam; PF01480; PWI; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF90229; CCCH zinc finger; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 135..162
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 243..315
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT ZN_FING 135..162
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 96..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 447..474
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 212..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 608 AA; 67855 MW; F2FCD765D5A19E3A CRC64;
MPFNDELDTP AFRAWLSRTI EPLCDADPTV LSDYIVALMK HDASMTEDEW KTFISRELVD
FLESSSGPFV ETLFQTLHSK NYDLTQTLPV PAAASHPIPT GPAAEVAPRP SAGPSTMQNG
QQKDVIMQEM PVGVSGRRKC RDYHERGYCM RGANCQYEHS ADMLIPTPEM MFQGFLPPFM
PGMPGVPIQY QGMQPMRPMA MQVPEFRDNP NGRNRSFGNR PPPSNEGESF EGSSRPPSDH
SKTTLLITDI PDANMSVVAI RNYFQQFGTI TSVALEGRGN RALVSFASNL EAYKAWKSDE
AVFGNRRVKV LWHKPRPGQG AAGQKALEQS KQLLENLQKM EAGEGPNQGI KPKLSGPETR
LQATLAELEH REKQSKKEPL IAEQKVLLKR ASTGTKEEKV QILKRLREIT KELDIINNPP
PKPESMDVDD AKSRLDRELA AHGMEMGGQD EEELARLNAQ LASLKEKANT LGVNASARYS
PYSRGRGGRG RGRGGPPRPM RLDNRSRTIL VSGDRFGDEE ARRVVQEWYE STGGGVEFVD
GSLRITYPQR EMAEKALALG TNELREKAGP IRTAWEPLKP LERYQPSDVE MTVHMGEEEL
RGEKDDDE
//
