ID Q5KA86_CRYNJ Unreviewed; 327 AA.
AC Q5KA86; Q55L98;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 24-JAN-2024, entry version 88.
DE SubName: Full=Dihydrodipicolinate synthase DapA, putative {ECO:0000313|EMBL:AAW46033.2};
GN OrderedLocusNames=CNJ02600 {ECO:0000313|EMBL:AAW46033.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW46033.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW46033.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
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DR EMBL; AE017350; AAW46033.2; -; Genomic_DNA.
DR RefSeq; XP_567550.1; XM_567550.1.
DR AlphaFoldDB; Q5KA86; -.
DR STRING; 214684.Q5KA86; -.
DR PaxDb; 214684-Q5KA86; -.
DR EnsemblFungi; AAW46033; AAW46033; CNJ02600.
DR GeneID; 3254101; -.
DR KEGG; cne:CNJ02600; -.
DR VEuPathDB; FungiDB:CNJ02600; -.
DR eggNOG; ENOG502RBA9; Eukaryota.
DR HOGENOM; CLU_049343_4_1_1; -.
DR InParanoid; Q5KA86; -.
DR OrthoDB; 1434381at2759; -.
DR Proteomes; UP000002149; Chromosome 10.
DR GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IBA:GO_Central.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR PANTHER; PTHR12128:SF38; DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G00110); 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
SQ SEQUENCE 327 AA; 35774 MW; E28C48F66232090B CRC64;
MTANGFSDNV SKFSNPRGRV GFDMSGITPA PVTPFNEDGS VDYEAIQRIG SWLASVEGVK
GLVVLGHAGE GTFLTSEEQV KVIKAFVKSV NNEIPIIAGI TREGNYVAGL EAKRAREAGA
AAGLLYPSHG WLRFGYQTGA PQVRYKEVYE ASGLPLILFQ YPDNTKATYD LKTQLDILAQ
PGVFAMKNGV RNMRRWDREI PVIRKARPDI YILTCHDEYL LHTTFDVDGM LVGYGSIAPE
LLFELLKAGK AHDYKKARAI HDQLLPVTAA VYHRGSHMEG TVALKHALVA RGILKHATIR
GTLLPLPEGA DKEIYDAISA AKIAKVQ
//
