ID Q5KAW6_CRYNJ Unreviewed; 710 AA.
AC Q5KAW6;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=ATP-dependent RNA helicase {ECO:0000256|RuleBase:RU365068};
DE EC=3.6.4.13 {ECO:0000256|RuleBase:RU365068};
GN OrderedLocusNames=CNJ00220 {ECO:0000313|EMBL:AAW45762.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW45762.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW45762.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: RNA helicase. {ECO:0000256|RuleBase:RU365068}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|RuleBase:RU365068};
CC -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box
CC family of RNA helicases and controls ATP binding and hydrolysis.
CC {ECO:0000256|RuleBase:RU365068}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family.
CC {ECO:0000256|RuleBase:RU365068}.
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DR EMBL; AE017350; AAW45762.1; -; Genomic_DNA.
DR RefSeq; XP_567279.1; XM_567279.1.
DR AlphaFoldDB; Q5KAW6; -.
DR STRING; 214684.Q5KAW6; -.
DR PaxDb; 214684-Q5KAW6; -.
DR EnsemblFungi; AAW45762; AAW45762; CNJ00220.
DR GeneID; 3254163; -.
DR KEGG; cne:CNJ00220; -.
DR VEuPathDB; FungiDB:CNJ00220; -.
DR eggNOG; KOG0342; Eukaryota.
DR HOGENOM; CLU_003041_26_6_1; -.
DR InParanoid; Q5KAW6; -.
DR OMA; REAMTAC; -.
DR OrthoDB; 276261at2759; -.
DR Proteomes; UP000002149; Chromosome 10.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24031:SF384; DEAD-BOX ATP-DEPENDENT RNA HELICASE 31; 1.
DR PANTHER; PTHR24031; RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU365068};
KW Helicase {ECO:0000256|RuleBase:RU365068, ECO:0000313|EMBL:AAW45762.1};
KW Hydrolase {ECO:0000256|RuleBase:RU365068};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365068};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW RNA-binding {ECO:0000256|RuleBase:RU365068}.
FT DOMAIN 157..359
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 387..566
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 196..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 77345 MW; 2069E80B00B83E1D CRC64;
MLPRQLSRAP RALGYVLPRF SPPSSVLRTV TPAFARSTQL SLRRILEKRG YAVSAVAEKD
DDFFSGAELA PSSNTVVIPP QLDDPGHPAS EPLVDTVPFE SLKGRINHDT LKALTVKPFK
FTAMSEVQKR VLGLLPHLSG GKLRSKAREE AEQEGEVEMK EEREDLLVKA KTGTGKTMAF
LVPAIDARIN TLERLSKAPN PDGTIPDKHA QGRNHRAISR SHLGALIISP TRELATQIAV
EAEKLCTWHK DLTVHSFVGG ESRLRQLKEF SRRSKDVVVA TPGRLRDLIS EPLVKDALAK
TDMLVLDEAD TLLDMGFSED LKFIIDHLPK ERQTLFFSAT VSKEIAAIAR HSLRKGHKVI
DCVPKNESNV HLHIPQYATV VPSSADAMPH IMRLIAQDQM ANPKSKIVLF LNTTKQTMLT
ATLVRELVDT LPAQTAVYEI HSKLDQNKRT RSSDKFRREH RPAVLVTSDV SARGVDYPGV
TRVIQLGVPS TTEQYIHRVG RTGRAGKEGR GDLVLFPFEA GFLDHLKGIP IQRISTSDLT
SDVIAKAPSS YASVIDSLPS AVESLLPTLD PKAVEEVFMS MLGYYHSKQQ MLDASAQDIL
KGLKAWSVEG GGLIEPPYVS EEFLKKVGFS EKRRNTRNGG GGSRGGFGRS SGGFGRGSGG
FGKRDGGRRE DSGGFGGRGQ GGGGSGFGAR RDGGGGFAGK SRSGGFKRDY
//
