ID Q5KBL4_CRYNJ Unreviewed; 2017 AA.
AC Q5KBL4; Q55N83;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 24-JAN-2024, entry version 132.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN OrderedLocusNames=CNI02140 {ECO:0000313|EMBL:AAW45337.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW45337.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW45337.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017349; AAW45337.2; -; Genomic_DNA.
DR RefSeq; XP_572644.1; XM_572644.1.
DR SMR; Q5KBL4; -.
DR STRING; 214684.Q5KBL4; -.
DR PaxDb; 214684-Q5KBL4; -.
DR EnsemblFungi; AAW45337; AAW45337; CNI02140.
DR VEuPathDB; FungiDB:CNI02140; -.
DR eggNOG; KOG0902; Eukaryota.
DR HOGENOM; CLU_000893_0_2_1; -.
DR InParanoid; Q5KBL4; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000002149; Chromosome 9.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IBA:GO_Central.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 2.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1451..1637
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1733..2001
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 2017 AA; 224024 MW; 14F2FF855192C2C3 CRC64;
MDSLDEPLHL HILTSLASSY AAHPSNSDEQ PIHALTRGLP QTALSTSAGQ GLPGSDEEDD
EWTELEINHA ISYAHYVYSL PITSLNLAAS VEKLKKLLWG LIRQGTIVVD PIASPASSSS
ARADVGLAGS VGQAQLCQDL IKAMIWAGWS SEEARSDVGE TLVRLGQQIA DLCSSNAQTT
FPLVLLNSIH SVITHCPLPP FPTSIVARLV SAFLPISSPK FLVKLVRQSS SAASTPHFRL
PKNSPFLAQY PSSPVAVVML VTEAITALLG NSLFSQPDIN EVQKAFVKHS DQMNSPFLPN
SEPSGSRPVL EHQINQLVSF PVEGHGLSST PEGRAVLAEA DRMSLRWWSD LMGSTYVDAE
RELPGRRGNL FAHGRNEPEE EVDLTVAVLH LMNMIVLRQP DGDKTQLARL KMLLSESSTI
TDARVLEAAF TCTTILVRNN PSLGTPMTHH IRRLLMTPLP AFEGEIAGLG GDVPPAVVAA
GKCLSVCIEM SANDDLTSST LYSLLNTLSH GQGNSGSAGV NSIRSLPLHY QGGEADTYTL
KTTLTGGKGS EEQRRLVAAA AVQVVSRLAL ELGKDDILHL SLAMLLQRLR GVDIATEATI
VANLVPLALA SSNADLIEVY RAFSQIARSS HPEDPRRSSN AILAALTTLA KGMYKRLDCA
DGYLVELLTL FADKGTQTQM ISMAAHAFDS KDREQLAQLR TEGNTRVADM KSWLSALLIP
ISTLLSHPHY HPDQAASPEL VTHFRNLWFT LVVFGLSGSV GKNNLNEHEW EALGVIAEKT
PVLVLESSND FVESELEYNS TLRKDFAASI QHRQSTALNE YLPQQRQSYD TRNLSTPQIT
FLMAVHDLEE MRTLRHRPSV VLQYFCNVSL NTSSLIGCLD AIVQKVSKSF LRQLYHQAIT
HSLPPIISKE VCKILVACTH RMSKVREKAL AYAHLILETF SALLCDKEVV FTLLEILTLM
RRSCETQYTD EYSPVYEFSS DRMDLTLHLT DDYAVRNEIV TQLHTVTCTW LTLAISRAPI
EVQSILQSYL NEARDVLLID SVEMGAGLAL HFSKAISKLD RQETIMPNIG GWPSDSSNLV
ASQFASKNYH TGELSGARLV LSQGLSDLQK GSPTESSQAE LAAFKFQMAQ SVSNIRINSK
SLDVPEIRRL LLRGVSVLVA SRRMDRDILH YLVELPMVAF TPLAIAAGVD AWTWLLRQRP
EAEVAIVGAI TAGWMQTIIE KKGFFNNSMN YQDPFERPVE YSPSDKKITD LELAKARRLL
RPHTLLVQVL SSQFHAIKYR ERAMTIALIR LMMRSLEAHR EMSTHPLARE VRFSFLLFGF
QILSSSRMEA LLELRLRDNL YNAAFSWFSV RPQWSYGSDR IQVGAEIKLL QDFLSAVAND
GIRAEHYTSS MADRTPAFLI PGASSIQEYL VQHKDRVRLL QLLVENEISR LAVWSNPVNE
HGRTSAPAVG SLERSTSATD WTRLLQTAWK LNPAMAVQMG ERFKISSLQA EISHLVKSDP
KAVQDVAEAL HFLLGDKLEQ DAKAALKWLP LWAAVPPVTA IVYFQPRYGN HPLILQYAMR
VLEQHPVELT FFFVPQVVQA LRADGLGYVE RFIFETSKIS QLFCHQIIWN MKANTYRDDD
ASQPDPMKPL LDRMIDMIVH GLSGKSKAFY DLEFDFFDEV TSISGKLKPF IKKSKPEKKA
KIDEEMAKIK LSVGVYLPSN PDGVVVDLDR KSGRPLQSHA KAPFMATFKV QKEKLDLPSN
QSIENPDEAK MVKTTYDVWQ AAIFKVGDDC RQDVLALQII AMFKNVFTSI GLTLYLYPYR
VTATAPGCGV IDVVPNATSR DEMGRAKIND LFSYFVDKYG GVDTASFQKA RLNFIQSMAA
YSVACYILQI KDRHNGNIMI DGEGHIVHID FGFLFDIGPG GMKFEPSSFK LNHEMVALMG
GRDSQGYKMF TELTVKAFLA IRPHADQIID AVHLMLGTAL PSFKGEGTII RLRNRFQLQL
GERQAAEFMM GVIRNAHENM RSNVYDGFQK MQNGIPY
//
