ID Q5KBY3_CRYNJ Unreviewed; 1514 AA.
AC Q5KBY3;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 117.
DE SubName: Full=DNA helicase, putative {ECO:0000313|EMBL:AAW45420.2};
GN OrderedLocusNames=CNI00970 {ECO:0000313|EMBL:AAW45420.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW45420.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW45420.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017349; AAW45420.2; -; Genomic_DNA.
DR RefSeq; XP_572727.1; XM_572727.1.
DR STRING; 214684.Q5KBY3; -.
DR PaxDb; 214684-Q5KBY3; -.
DR EnsemblFungi; AAW45420; AAW45420; CNI00970.
DR VEuPathDB; FungiDB:CNI00970; -.
DR eggNOG; KOG0952; Eukaryota.
DR HOGENOM; CLU_250509_0_0_1; -.
DR InParanoid; Q5KBY3; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000002149; Chromosome 9.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IBA:GO_Central.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961:SF7; ATP-DEPENDENT DNA HELICASE HFM1-RELATED; 1.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:AAW45420.2};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 204..385
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 447..640
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1212..1308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1409..1435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1469..1514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1250..1265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1269..1289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1412..1435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1469..1498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1514 AA; 169591 MW; 8AC7C94A0135D0A9 CRC64;
MDFEEDQPLW DGSRQEEEDV YFGKFGYAEG YESPYHPNNS PTPRYDIGLS SRSLNPGQNL
TGFSASQFNP SRHTPFPLIS DSHSLLTDLA LNRSTRQFTP ENSLARDHSA ILQRQQSENY
GDEIWEDEEF VEAVNESFNH EIDNAKEYDP VITAETIRSR EELRNKAVFN KNGKPLVPLS
RLPIDQRKLF KFPCFNNVQS EVFDDVYQSD ENLVVSAPTG SGKTTIFELA FLHNLSFRTP
DDSLKPLAVY IAPTKALCNE KAKDWQERLS QALPDVICNE ITGDYGNTST IYNSIRTADL
MVTTPEKFDS MTRRSRNLEN MSQRLRLIMI DEVHILRESR GATLEVVISR LKGLGRGIRF
VALSATVPNI DDIARWLGPT RNEYGQLSRG VLVGREVISA KEKRAPAVDD MPMAKVYKFG
EEYRPVPLQR ETYGIESTGN DWALANRLDK ELFPILLRHA AGQPVLVFCP TRKSCQATAE
SIFQSYEEAR AKGLKLPWQH PPGVRLELQD KKLTELSTCG IAVHHAGLDY GDRRAIEDGF
RDGKLHMIAS TSTLAVGVNL PAHTVVIKGV MAWQGASSGF QEYSDIDIQQ MVGRAGRPQY
DTSGVVVVMC ERSKVRKYQS MLNSQTVLES CLHENLTEYI NSEIGQGTIR SVSSAQEWLR
NSFFHIRIQQ NPKHYALSDA KDKPVEGAWE EWLDHYVEKA LINLEKDGFI ERADDDTLIP
TETGKIMSSS MISYGTMCSI KAMSPGSTVQ DLLEILAGST EFQDLRIRQG ESGFLNKLRI
NEEIRFPLAE AVKSYADKVF LLLQVTFGNI ILEDIAKKTE LTSPIQTLMA IYNHAPRIVK
AIVQFTLNRE YGIAARSALE LHRVVVGKAW EDLPTIFRQI PSIGPKSIRV LGQNGITNFD
QLLDVESEKI QLWLNRGHDF ARAIHEQARR MPRFHVTMEE ENMDYDGTYN VLNLRVNITP
KAKVIATESR GKRGGFITQY NLSTLFLNQS GGFIGYRRLE LKKLIKNKDN SFIIAVTLSK
RCDSVAAIVG VDEVAGCSTV IHYNTNLDDS VYPEDLEDDE NVEEPPSQRT LVEPTPELEE
ELLPNGNVKC HHSCKDKLAC QHVCCKSGVP PRKRNKAGAR ASGRSNVRTA ADRIRETQYC
VESPREELRP VGKAVRRIRQ GSQMSRSPSP ASNVQAANHK AAIVSEMQPN TRAVERVREA
RIVRGPLSST VAIEPRSRST TPIVPPKAVK NENIASGQIK EPLFLPGSDD DYNARHHEND
PSRKAIARSK AMSGSTSRYF DQPKTSGKAK NALSRKPPTM PVTSSASHPS ILDLLPGQAT
IKNNSDANSH DLGPIHGNFS DDGYETVRES PEMKHSRVFP HSKPSIDWYT EEIVQDDPEK
STEANKSHVV TNAQAPENWE FNIEEMFADI SGSPSSPKQL EEEPKSVLNI NPSPSLKQPA
RLIIGGFGRP SIKRQRLHED QHSSNYSLAQ PFAQSDNPDI LRANENGPTA QGPSASMPQN
EMDEFEDWYM GEGG
//
