ID Q5KDF5_CRYNJ Unreviewed; 1215 AA.
AC Q5KDF5;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 24-JAN-2024, entry version 121.
DE RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
GN OrderedLocusNames=CNG04180 {ECO:0000313|EMBL:AAW44864.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW44864.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW44864.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR005719}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005231}.
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DR EMBL; AE017347; AAW44864.1; -; Genomic_DNA.
DR RefSeq; XP_572171.1; XM_572171.1.
DR AlphaFoldDB; Q5KDF5; -.
DR STRING; 214684.Q5KDF5; -.
DR PaxDb; 214684-Q5KDF5; -.
DR EnsemblFungi; AAW44864; AAW44864; CNG04180.
DR GeneID; 3258928; -.
DR KEGG; cne:CNG04180; -.
DR VEuPathDB; FungiDB:CNG04180; -.
DR eggNOG; KOG0933; Eukaryota.
DR HOGENOM; CLU_001042_9_0_1; -.
DR InParanoid; Q5KDF5; -.
DR OMA; HNKIAME; -.
DR OrthoDB; 231904at2759; -.
DR Proteomes; UP000002149; Chromosome 7.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0000793; C:condensed chromosome; IBA:GO_Central.
DR GO; GO:0000796; C:condensin complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007076; P:mitotic chromosome condensation; IBA:GO_Central.
DR CDD; cd03273; ABC_SMC2_euk; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR027120; Smc2_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR43977:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005719};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 524..645
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 1177..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 243..325
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 406..472
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 686..928
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1215 AA; 135486 MW; BFEE680967F2D87F CRC64;
MRVEELILDG FKSYPVRTTI SGFDESFNAI TGLNGSGKSN ILDAICFVLG ITNMQSVRAN
NLMDLIYKRG QAGVTKASVT IVFNNEDRSK SPVGFENTPQ ITVTRQIAVG NVSKYLLNGH
KSTLQALQNL FQSVQLNINN PNFLIMQGKI TKVLNMKPAE ILGMVEEAAG TRMFEERKDK
AMKTMTKKDK KVEEIESLLR EEIDPKLEKL RAEKRSYLEY QKATSELERL TRLVKAYEWV
AAVEKAEKAT ETVKKKRKDI ETAKGDIMRG GKECHGMEKE LEEIRKKKEK EQAKGGKIQG
LTEAVNNLER ELVKIKTQIE ITESTLKDDA KRVEGAKKTV GELSKTLEDR RSETSKESSA
FAELKDAYDA GQAELSKLEE LLQSLLTGLS SNQNDEENAG GYLGQLAEAK ARLAAAGTEA
EQAKVKIGLA EKELKEKEPR AKKAEKDGEG LVKELAAKRA QMEKLRKQVE SAGWDEQQER
EMLESQAEHQ SKMTELMDKR DMLKSRLASI DFTYSDPEAN FDRSKVKGLV ANLVDLDEEN
FSNSTALEIC AGGKLYNVVV HDEKVGSKLL KNGNLRKRVT IIPLNKIDAT KIAAEKLAAA
HRVAPGKVNL ALDLVGYPED VSAAMAYVFG RTFICADKRT AEAITFNKSI AVKSVTVEGD
VYDPSGTLSG GSAPSSGGVL VKVQELKQIE REIAKHRSAV EEIRSKLQSA KKVIDQWKKD
KKNLELSEHE VRLLEEQIKG SNATKIIAEV EAARTSLADL KNIVNQAKEK QKQASADCKR
LEKEMADFKN NKDSKLNEIK ANITSKKNEL GKKTLQVKTR QKAIQTAELE LQQLESDLES
AKAEVEEATA AQAKTKAEHS ALQESFKASQ SDHKAAETKL RSEEAVLVAF DNELADLERD
LKAKKQDISD AELSLKKLEH DLGLVEKEKA SLVDHKVNLE NRFQWILDEH QFFGKIGTPY
DFRSVDLQQA RDQCRELESQ ANGMGKKINP KVMNMIDSVE KKEQALKKMM ATVLKDKSMI
QDTIEELDRY KRDALTKTWE KVNGDFGLIF AELLPGNFAK LQPPEGQDLT QGLEVKVRLG
SVWKASLTEL SGGQRSLIAL SLIMSLLQFK PAPMYILDEI DAALDLQHTQ HIGQLFRNRF
KGSQFIVVSL KEGLFTNANV LFRARFRDGT SIVERTERRS NALHSSSSDK ENAQEPVAGK
GNKRTGDSRA PLAAR
//
