ID Q5KE12_CRYNJ Unreviewed; 580 AA.
AC Q5KE12;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 24-JAN-2024, entry version 87.
DE SubName: Full=Specific transcriptional repressor, putative {ECO:0000313|EMBL:AAW44611.2};
GN OrderedLocusNames=CNG02110 {ECO:0000313|EMBL:AAW44611.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW44611.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW44611.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017347; AAW44611.2; -; Genomic_DNA.
DR RefSeq; XP_571918.1; XM_571918.1.
DR AlphaFoldDB; Q5KE12; -.
DR STRING; 214684.Q5KE12; -.
DR PaxDb; 214684-Q5KE12; -.
DR EnsemblFungi; AAW44611; AAW44611; CNG02110.
DR VEuPathDB; FungiDB:CNG02110; -.
DR eggNOG; KOG0527; Eukaryota.
DR HOGENOM; CLU_034109_1_0_1; -.
DR InParanoid; Q5KE12; -.
DR OrthoDB; 3039455at2759; -.
DR Proteomes; UP000002149; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd01389; HMG-box_ROX1-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR45789; FI18025P1; 1.
DR PANTHER; PTHR45789:SF2; FI18025P1; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 186..255
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 186..255
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 15..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 64557 MW; 8781DDF71FC22D27 CRC64;
MDNFWMTNGF VGMPAGPIED SPHDSFALSS IPPDHAHPQP YQSQTNFPYQ PHVHPYSLRT
QRSTSSLSGW STVTSDTNTA SDFDDDASSM SAFSSNVSPQ SLWVGPQNQS SQSSPQRAPS
LSIDPKLFAP MEKDGKADEG MLETAKPKEL ARAEVTAVVL GSSKKEKLEN CKKKVSHARK
QTADHIPRPR NAFILFRKHV VDAKLIPASV EMRHQNVSII TAKMWSEAPA EQKAHFNELA
RIEKEEHMKK YPGYRYQPVY RRTNVVRRRV RKDEAEEEKC KNVAELLMKG KSGQQLEEEI
KDKIANGDTK GAKKNKSMNG VCELSKGALR ALRAQARQKQ EPFNSGDWSD LSCSTSMDPD
AQGSRRRQSS AFESTRSSQS PKPANGFEHR LLQAQNQGPR RQLQYMAYSH QDLAPWSGDI
PAEPNEKQAF AFTSSQQGFQ PGQQSPPTFS IAAHTYPLTS RHFLYPQPQP QFQLTIMPDQ
QVSNQFYVHD AALPFSPSAG QFTLQGQNTS MHADDMPTFN IGSAQQQVVH PPMSARWDKG
HLLPPSSDVP LEGLPFDDGL MLGDFEAALA HADDMVGGVW
//
