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Database: UniProt
Entry: Q5KIN6_CRYNJ
LinkDB: Q5KIN6_CRYNJ
Original site: Q5KIN6_CRYNJ 
ID   Q5KIN6_CRYNJ            Unreviewed;       849 AA.
AC   Q5KIN6; Q55TP9;
DT   15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2005, sequence version 1.
DT   07-JUN-2017, entry version 83.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   OrderedLocusNames=CND02320 {ECO:0000313|EMBL:AAW42964.1};
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 /
OS   ATCC MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW42964.1, ECO:0000313|Proteomes:UP000002149};
RN   [1] {ECO:0000313|EMBL:AAW42964.1, ECO:0000313|Proteomes:UP000002149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J.,
RA   D'Souza C.A., Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J.,
RA   Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I.,
RA   Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E.,
RA   Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L.,
RA   Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A.,
RA   Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R.,
RA   Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W.,
RA   Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen
RT   Cryptococcus neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; AE017344; AAW42964.1; -; Genomic_DNA.
DR   RefSeq; XP_570271.1; XM_570271.1.
DR   UniGene; Fne.6363; -.
DR   STRING; 214684.XP_570271.1; -.
DR   PaxDb; Q5KIN6; -.
DR   EnsemblFungi; AAW42964; AAW42964; CND02320.
DR   GeneID; 3256882; -.
DR   KEGG; cne:CND02320; -.
DR   EuPathDB; FungiDB:CND02320; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; Q5KIN6; -.
DR   KO; K02154; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000002149; Chromosome 4.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002149};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    419    452       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    473    490       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    548    565       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    586    604       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    642    662       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    781    806       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       98    139       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   849 AA;  96013 MW;  5C2F8557AC81449A CRC64;
     MATNYPSLFR SEEMSLVQLY IPSEVAHDTI SELAEMSNFQ FKDLNPSLTS FQRPFTPRLR
     RLAEMARRLR FFRSQITSLS PPLGVPPLAA VPPFTTVGPR AQNAYDELEE KLKEHERRLN
     EMNKSWEELG RRKSELEENK CVLKETAGFF DEAGHRHTEI RTSMEDSSDA APLLEHAAEY
     GTLPGESGLS GFDLEFVAGT IDRARMPTFE RILWRVLRGN LYMNYSEIEE PFVDTVSGKE
     TFKDVFIIFA HGQELLAKIR KVAESMGGTL YNIDSATDKR SDALRQVSAR LEDVDNVLYN
     MGQTRRVELS KIAESLEAWT DAVMREEEIY KTLNLLSYDQ GRKTLVAEGW CPSRDITAIQ
     LGLRRAMDTA GTSVPAILSE LRTHQTPPTF HRTNKFTEGF QTLIDSYGIA TYQEVNPGLY
     AVITFPFLFA VMFGDIGHGI LMFLTAAAMI FWERQIAKNG VNENVETFFF GRYLIVLMGI
     FSVFTGFMYN DIFSKTLHLW QSGWEWPSNS TGLIEAEPTG NIYPFGMDPM WHGSDNALIF
     NNSYKMKMSI ILGVIHMTFA ICLQVPNHIH FKKPLNIYAE FIPQMLFFHS IFGYLVVCII
     YKWSVDWSQS VTSPPGLLNM LIYMFLSPGT IEPGTQLYAG QGFIQVVLLL IALVCVPWML
     ALKPYMLWKE HQRIVAQGYQ GLQGQDNGGM HGRDSIGAES RAEEEEEVGM AVAESSDEEH
     PFEMGDIIVH QVIHTIEFCL GCISNTASYL RLWALSLAHA QLSEVLWSMT LQLAFDFNGG
     LISRAVFLFV MFAVWFGGTV GILCVMEGLS AFLHALRLHW VEANGKHYMA GGYPFTPLSF
     ATIGQEEDI
//
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