ID Q5KIU5_CRYNJ Unreviewed; 543 AA.
AC Q5KIU5; Q55TJ1;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=Carboxypeptidase {ECO:0000256|RuleBase:RU361156};
DE EC=3.4.16.- {ECO:0000256|RuleBase:RU361156};
GN OrderedLocusNames=CND01720 {ECO:0000313|EMBL:AAW42959.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW42959.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW42959.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SIMILARITY: Belongs to the peptidase S10 family.
CC {ECO:0000256|ARBA:ARBA00009431, ECO:0000256|RuleBase:RU361156}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017344; AAW42959.1; -; Genomic_DNA.
DR RefSeq; XP_570266.1; XM_570266.1.
DR AlphaFoldDB; Q5KIU5; -.
DR ESTHER; cryne-q5kiu5; Carboxypeptidase_S10.
DR MEROPS; S10.006; -.
DR PaxDb; 214684-Q5KIU5; -.
DR EnsemblFungi; AAW42959; AAW42959; CND01720.
DR GeneID; 3257465; -.
DR KEGG; cne:CND01720; -.
DR VEuPathDB; FungiDB:CND01720; -.
DR eggNOG; KOG1282; Eukaryota.
DR HOGENOM; CLU_008523_12_3_1; -.
DR InParanoid; Q5KIU5; -.
DR OMA; ATCENLM; -.
DR OrthoDB; 1647009at2759; -.
DR Proteomes; UP000002149; Chromosome 4.
DR GO; GO:0004185; F:serine-type carboxypeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001563; Peptidase_S10.
DR InterPro; IPR033124; Ser_caboxypep_his_AS.
DR InterPro; IPR018202; Ser_caboxypep_ser_AS.
DR PANTHER; PTHR11802:SF479; CARBOXYPEPTIDASE; 1.
DR PANTHER; PTHR11802; SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE; 1.
DR Pfam; PF00450; Peptidase_S10; 1.
DR PRINTS; PR00724; CRBOXYPTASEC.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00560; CARBOXYPEPT_SER_HIS; 1.
DR PROSITE; PS00131; CARBOXYPEPT_SER_SER; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645,
KW ECO:0000256|RuleBase:RU361156};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361156};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU361156};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Signal {ECO:0000256|RuleBase:RU361156}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|RuleBase:RU361156"
FT CHAIN 21..543
FT /note="Carboxypeptidase"
FT /evidence="ECO:0000256|RuleBase:RU361156"
FT /id="PRO_5005143661"
SQ SEQUENCE 543 AA; 61510 MW; 34B0E54FDC90F67E CRC64;
MWCKLLTTAL LAFALGSVVG TARYTHGLRG RRPAALASMR EAKREALARE TSRMEESRAL
LERHPKRKFY NNRTSEFFIK YLPDVQFDLG EVYSGLIPID YNNQSEALFF VFQPKLGKDS
KDLTIWLNGG PGCSSLEGWF QENGLWIWQP GTYAPVINPY SWVNLTNMLW VEQPIGTGFS
IGTPKATTEE EIAQDFIKWF KNFQDIFGIK NYKIYVTGES YAGRYVPYIS AAMLDAQDKT
YYNLSGALMY DPTIGETINV QEEILTYSFV EANANLFNFN KTTMAELKQL HEVCGYKEYI
DRYFKFPPTE NQPPLFFDYN DPVDIMCDIF GMVNDLALQI NPCFNIYGVN LMCPLPWDVL
GMPTQLNYAP GGVYFNRSEV KAAIHAPKHI EWAGCAASPV FVGGEGGPQS NGDLSVDPIQ
KVLPRVIEAT NRVLVSNGDF DMVIITNGTL LAIQNMTWNG HLGFQSPPSE YIVIDINDTQ
WSSVFESNGL HGYPGTQGVM GIQHYERGLM WAETFQSGHM QPQYQPRSAY RHLQWLLGHV
DRL
//
