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Database: UniProt
Entry: Q5KJG0_CRYNJ
LinkDB: Q5KJG0_CRYNJ
Original site: Q5KJG0_CRYNJ 
ID   Q5KJG0_CRYNJ            Unreviewed;       469 AA.
AC   Q5KJG0; Q55WT7;
DT   15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2005, sequence version 1.
DT   24-JAN-2024, entry version 122.
DE   SubName: Full=Xylitol dehydrogenase, putative {ECO:0000313|EMBL:AAW42610.1};
GN   OrderedLocusNames=CNC06670 {ECO:0000313|EMBL:AAW42610.1};
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW42610.1, ECO:0000313|Proteomes:UP000002149};
RN   [1] {ECO:0000313|EMBL:AAW42610.1, ECO:0000313|Proteomes:UP000002149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; AE017343; AAW42610.1; -; Genomic_DNA.
DR   RefSeq; XP_569917.1; XM_569917.1.
DR   AlphaFoldDB; Q5KJG0; -.
DR   STRING; 214684.Q5KJG0; -.
DR   PaxDb; 214684-Q5KJG0; -.
DR   EnsemblFungi; AAW42610; AAW42610; CNC06670.
DR   GeneID; 3256238; -.
DR   KEGG; cne:CNC06670; -.
DR   VEuPathDB; FungiDB:CNC06670; -.
DR   eggNOG; KOG0024; Eukaryota.
DR   HOGENOM; CLU_026673_11_5_1; -.
DR   InParanoid; Q5KJG0; -.
DR   OMA; CHNWESD; -.
DR   OrthoDB; 2247176at2759; -.
DR   Proteomes; UP000002149; Chromosome 3.
DR   GO; GO:0003939; F:L-iditol 2-dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006062; P:sorbitol catabolic process; IBA:GO_Central.
DR   CDD; cd05285; sorbitol_DH; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR045306; SDH-like.
DR   PANTHER; PTHR43161; SORBITOL DEHYDROGENASE; 1.
DR   PANTHER; PTHR43161:SF9; SORBITOL DEHYDROGENASE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          81..176
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          348..425
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
FT   REGION          278..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   469 AA;  50141 MW;  E5E7DF854DE204E7 CRC64;
     MAEFHFLNKT QPPQVTKLNL PDNTSCILLK KRNIVVKPRP MPILQPDGVL VKVVATDKLI
     HCEEYDKTAG KLTCLLILSR ICGSDLHNYL AGGVGGRPVT EPIVMGHESS GEVIAVGDLV
     KTHKVGDRVA IEPGLPCRRC INCKEGKVNI CLNMHYCGAP GSVGSLSRYF ALPADMAPHI
     PDHLSWEEAG CIQPLAVGIQ VGKRVDLRPH KTVAIFGCGP IGLISAAVAH AYSARKIIAF
     DNNPQRVEFA KKYISPLTGK PIIDHVFLVK DLPTSSLKGS HANGDHANGN GSMANGDTET
     LAHALGEDGS GAGMGDGEIL DEDHEETIGD KKWEWAKKIV AGFVQEAGLT AEEGVDRVVE
     ATGAEDCMLM GIAIAKQGGN YLAVGLGHIQ TNCFPTLAVT NKEINVMGIT RYTASCFPSA
     LDLLSRGVVD VKQLITKTFP LTQSTEAFEA VAAGQDMKVV IKNQEGFDN
//
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