ID Q5KJH6_CRYNJ Unreviewed; 1471 AA.
AC Q5KJH6;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 24-JAN-2024, entry version 98.
DE SubName: Full=Suppressor protein SPT23, putative {ECO:0000313|EMBL:AAW42600.2};
GN OrderedLocusNames=CNC06520 {ECO:0000313|EMBL:AAW42600.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW42600.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW42600.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017343; AAW42600.2; -; Genomic_DNA.
DR RefSeq; XP_569907.1; XM_569907.1.
DR STRING; 214684.Q5KJH6; -.
DR PaxDb; 214684-Q5KJH6; -.
DR EnsemblFungi; AAW42600; AAW42600; CNC06520.
DR VEuPathDB; FungiDB:CNC06520; -.
DR eggNOG; KOG3836; Eukaryota.
DR HOGENOM; CLU_250347_0_0_1; -.
DR InParanoid; Q5KJH6; -.
DR OrthoDB; 2901153at2759; -.
DR Proteomes; UP000002149; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR PANTHER; PTHR23335; CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA; 1.
DR PANTHER; PTHR23335:SF0; CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR, ISOFORM F; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1430..1460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 812..893
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT REPEAT 1018..1050
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1051..1083
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 915..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1342..1418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..808
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1366..1388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1471 AA; 157019 MW; 0D414800072FC8DD CRC64;
MLPIDSPSVF SSPFSARSTI ESSPEAVGGQ NSDPRSNGHG IEAPAGVMQA LLGEVNGSHA
QKPLPITRSS LPAQPQQYQS SRSDIKPLLD TKPFHSVSTP MAGSSKVSDR VSAMNSAGIP
SVSANTGASA YGGSRAEPPK RMYDVEGLST VDPSLDDLMA GSNGRNQLLL QGDPLYADKS
RVETAIRVII DILRLAPLHS PIPPPSLHPL IPKGPNGDLL MTFERISTFH GLRLQAGTTT
KNSSKKQLQA IGHIPKDKLA YLETAVYMSG EDGKRVYVCK RCRNRETRRR EAKDRNRKRA
QPATSDSDAA SPASKPPRQS LVPPSVDFIT AENPDDYDPK RAGQMVEEPS WDPDCADWRH
DIVLFNTPAE VKLEDGSCNW LPFRVVCYGK CHGEKVGFRI KFTLRTYDGR ILATSMTKPI
RITDDHKTDT KAKPKPIAIE GPPQPAVARR KARPNVALMA SSRPQSPSPS EAESVQSFQS
LGEAGAVIQK QTPSVRAGKP YERPIQSTQP SQAPSPVSYV AAQMAGLPSA NFFSNGTNGV
TPSHAPPPQT AHQPMQMSND LNMSQYIHTV SPHELRGPQF QSTSTNISSY SVPHSGTPSA
ASSTAASPRT QMAGIQDDIM KSGFPAGLLE SLGLNRPNGN AGQGQGPMLY HARDTDAEMA
NLISGGFDDL FAGSSRASVS SMDNDQASVS SASVFSGWDD RSSAMFSQSG LPPGTTVVED
VDEDMEKYLD YTGENGVQGD HQRSRVASSF SSPLTGSNFS GLPFDEPFHS PLNSDLRHQI
QEQQRQPIPP QSSFPALVPA PAPALTAPQA PQPAITHVIP GEGPMAGGPT IAIAGQAFQP
GMVVVFGQRP AATEFVSSGF MQCKLPPSAF AGVVEVTIQG IGSVAGKMVF SYTDMEKDAM
KLALAIQSHY QGSQSDPTYR LAHQVARSSS SQRSHSNSAS PSGQSPGDNL NISAAANLNV
MDTGEDTDSQ TSSLDSKSTD DSTNSDLQST IITFLASIDS HAPGSLRASG AINHTNASQQ
TLLHIASAMG FSRLVRRLII GGAQIDVQDT NGYTPLAFAA LCGRHTCARV LIEAGAWYDR
ATNYGEMPLD LAKFGEHSKV ERLLLSAVWS TTAEPIETGA VAAVMAGGMG ERGSQKASGG
SPRSVAASLT SSIDDDNPSS SSEVEDDVTK FRRSSMPSRP RSKSRQSKDK RPMSIKSGRS
ERHHLSSISV VRAPSNVGET MDDPPPYAPP TDHSRIGVHP AHADDHDSWM KALASLPHVP
HFLPSGVWDH LPSRHSLFGS DKSARTASEH EHGSSSHGWV AFPTPSWETL TRMASPEEVK
LFTQAMAAAA LNAVVQTGAT TPAIRSGPRA RKSNAGLPAA DTELDMDAEG EGRKKGREDE
EGVKNGSKSR RRKSASASGL GGATMVSAKR SDSASPDNVV NHVKRDRMLY LFWLPILLFV
GFWLLVSALP IATGFGLIYA RKITKAIKGR M
//