ID Q5KM31_CRYNJ Unreviewed; 491 AA.
AC Q5KM31;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Aminotransferase class I/classII domain-containing protein {ECO:0000259|Pfam:PF00155};
GN OrderedLocusNames=CNB03180 {ECO:0000313|EMBL:AAW41587.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW41587.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW41587.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC aminotransferase family. {ECO:0000256|ARBA:ARBA00007441}.
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DR EMBL; AE017342; AAW41587.2; -; Genomic_DNA.
DR RefSeq; XP_568894.1; XM_568894.1.
DR AlphaFoldDB; Q5KM31; -.
DR STRING; 214684.Q5KM31; -.
DR PaxDb; 214684-Q5KM31; -.
DR EnsemblFungi; AAW41587; AAW41587; CNB03180.
DR VEuPathDB; FungiDB:CNB03180; -.
DR HOGENOM; CLU_017584_0_6_1; -.
DR InParanoid; Q5KM31; -.
DR OrthoDB; 5486605at2759; -.
DR Proteomes; UP000002149; Chromosome 2.
DR GO; GO:0047536; F:2-aminoadipate transaminase activity; IBA:GO_Central.
DR GO; GO:0008793; F:aromatic-amino-acid:2-oxoglutarate aminotransferase activity; IBA:GO_Central.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009074; P:aromatic amino acid family catabolic process; IBA:GO_Central.
DR GO; GO:0019878; P:lysine biosynthetic process via aminoadipic acid; IBA:GO_Central.
DR GO; GO:0006571; P:tyrosine biosynthetic process; IBA:GO_Central.
DR CDD; cd00609; AAT_like; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR PANTHER; PTHR42790; AMINOTRANSFERASE; 1.
DR PANTHER; PTHR42790:SF21; AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 111..472
FT /note="Aminotransferase class I/classII"
FT /evidence="ECO:0000259|Pfam:PF00155"
SQ SEQUENCE 491 AA; 54129 MW; 185FCB1C58A59840 CRC64;
MPSVAAVPVK LDYQSFLSQE AKGRVRSPLR DLRYFHAIPG MISFGGGLPH PSTWPVNAMT
LSVPFAKKSI FIPGYESNDP TSLYPLAPYI PPTKLNSVTE PLIPDLARDL QYSSNFGLPY
FVDWLTQHVK RIHDPPYPEN QWQVLATAGN TDASDGVVRT LCSPGDSILL EEFAFPGSLT
HYKSLGIKCA GVPMDGEGIV PSALEKILAE WDDEARGGPK PKVILIVPTC SNPSGITYPA
SRKREIYAVC RKWNLLIIED DPYCYLQVRP NGADTPLIPS FLSLDLDGRV VRLDSFSKFI
APGSRCGWIT GAKELVTTIM VKAEASSNGP SGFAVASISA VIKAWGGHEG LERDYLPHIS
DTYSKRSNLM VSLIRKYVPA EAAECPDGSG GMFLWVRLRV ESHPQLSTLS PEEISDKVFH
TLIGEKVMVA PSSYFKTPGG PVWSKDEESK RIFVRLSFSL STADEMEEGV KRFARGLRKE
WGIRNLDEAE H
//
