ID Q5KPG5_CRYNJ Unreviewed; 512 AA.
AC Q5KPG5;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 08-NOV-2023, entry version 92.
DE SubName: Full=High-affinity nicotinic acid transporter, putative {ECO:0000313|EMBL:AAW40880.2};
GN OrderedLocusNames=CNA02880 {ECO:0000313|EMBL:AAW40880.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW40880.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW40880.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AE017341; AAW40880.2; -; Genomic_DNA.
DR RefSeq; XP_566699.1; XM_566699.1.
DR AlphaFoldDB; Q5KPG5; -.
DR PaxDb; 214684-Q5KPG5; -.
DR EnsemblFungi; AAW40880; AAW40880; CNA02880.
DR VEuPathDB; FungiDB:CNA02880; -.
DR eggNOG; KOG2533; Eukaryota.
DR HOGENOM; CLU_001265_0_1_1; -.
DR InParanoid; Q5KPG5; -.
DR OrthoDB; 318095at2759; -.
DR Proteomes; UP000002149; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR43791; PERMEASE-RELATED; 1.
DR PANTHER; PTHR43791:SF50; TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 61..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..479
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 512 AA; 56396 MW; 38DB9ACF83F6B317 CRC64;
MGNMSTFATA ATNKAEDCSS EVGISEKGVE AQDLKDVADI EVQVAGIDRA IERRMLRKQD
FGLLPVLATV YLFNALDKGN LSNAKTDGLD KDLGLVGNQY YLMITVFYIP LCLCGTPLSI
AAKRFSAARV IPLMMIGFGS CSLLSACVTN FGGLFALRFL LGIFESPMLP SVVFYLSQFY
TRGELARRVG VFYAASSISG AFSGLLAFGI FQIKSGRLHG WQYLFLIEGA GTVAFAIFAF
FWLPRSPATC WFFNEEEKQL SRMRMLRDGT SEIGEKVDFR DAFMPFIKDW RYIVWAFLAL
GLGVPLASVG NFLPQIVGRL GYSTVKTNLY TVAPNIVGTC FLVLFTQSSD YFRERAIHIV
IPLIITMIGF IILGTIDVLN YKGVAYFACF LLCIGSNTPS VLLSTWYSNN SISENKRVVL
TGVMVGIANA SGLISANIFR AQDEPKYIPA LAASAAFGGF TALLACSFGL YMRIENRRRN
FAQGLPKSYG SKDVPTEYLG RGPKDQAFRY MF
//